Sodium thiosulfate mitigates PM2.5-induced cardiotoxicity by preservation of mitochondrial function [0.03%]
硫代硫酸钠通过保存线粒体功能来缓解PM2.5诱导的心脏毒性
Bhavana Sivakumar,Gino A Kurian
Bhavana Sivakumar
Background: Exposure to PM2.5 triggers changes in myocardial structure and function, leading to a decline in the ability of heart to withstand further oxidative stress. This manuscript addresses the absence of a endogenou...
Matrix metalloproteinase 9 implication during colorectal carcinogenesis. Effect of doxycycline [0.03%]
胶原酶金属蛋白酶9在结直肠癌发生中的作用及多西环素的影响
Abdelkader Bounaama,Bahia Djerdjouri
Abdelkader Bounaama
Background: Matrix metalloproteinases (MMPs), including MMP9, play a significant role in colorectal cancer (CRC) progression, mainly by extracellular matrix remodeling. However, little is known about MMP9 role in aberrant...
Necrostatin-1 attenuates oral squamous cell carcinoma by modulating tumour immune response in mice [0.03%]
Necrostatin-1通过调节小鼠肿瘤免疫反应抑制口腔鳞状细胞癌
Lavanya Saravanan,Ashutosh Mahale,Vikram Gota et al.
Lavanya Saravanan et al.
Background: Necroptosis has been shown to play an important role in various pathologies, including pancreatic cancer (PDAC). However, its role in the progression of oral cancer (OSCC) remains unclear. ...
Dual ETA-ETB receptor antagonism improves metabolic syndrome-induced heart failure with preserved ejection fraction [0.03%]
双ETA-ETB受体拮抗作用可改善代谢综合征诱导的射血分数保留型心力衰竭
Francesca Lockwood,Marianne Lachaux,Najah Harouki et al.
Francesca Lockwood et al.
Background: Metabolic syndrome (MetS) is a multifaceted disease associated with heart failure (HF), which affects the vascular system. The endothelin (ET) system is a key player in MetS and HF; therefore, targets for ET r...
Atorvastatin ameliorates α-KGDH and GDH functions in rats with diet-induced hypercholesterolemia [0.03%]
阿托伐他汀改善饮食诱导的高胆固醇大鼠α-酮基戊二酸脱氢酶和天冬氨酸脱氢酶功能
Malgorzata Ewa Belczyk,Malgorzata Elzbieta Knapik-Czajka,Jagoda Maria Drag et al.
Malgorzata Ewa Belczyk et al.
Background: α-ketoglutarate dehydrogenase complex (α-KGDH) belongs to mitochondrial 2-oxoacid dehydrogenases family and is the key regulatory enzyme of cell metabolism. It is functionally interconnected with glutamate d...
JAK/STAT inhibitors mitigate sepsis-associated cerebral and cognitive injury [0.03%]
JAK/STAT抑制剂可减轻脓毒症相关的脑损伤和认知障碍
Mohini Singh Bhadauriya,Harshita Singh,Manisha Suri et al.
Mohini Singh Bhadauriya et al.
Background: Sepsis is a life threatening condition which triggers multiple organ failure. Sepsis-associated encephalopathy (SAE) is more prevalent form of sepsis which involves acute and long-term cerebral impairment. JAK...
Relaxin-2 mitigates the interaction between monocytes and endothelial cells by suppressing Egr-1 [0.03%]
(relaxin-2通过抑制Egr-1来缓解单核细胞与内皮细胞的相互作用)
Jing Bai,Hui Zhou
Jing Bai
Background: An overproduction of oxidized low-density lipoprotein (ox-LDL) can lead to vascular endothelial dysfunction. Relaxin-2, a novel peptide hormone, exhibits various biological functions within the cardiovascular ...
Second primary cancers and hormonal therapies for prostate cancer: A nested case-control study [0.03%]
前列腺癌激素治疗与第二原发癌症的相关性：一项巢式病例对照研究
Lucie-Marie Scailteux,Julien Bezin,Marion Gundelwein et al.
Lucie-Marie Scailteux et al.
Introduction: (Pre-)clinical studies have not ruled out a potential risk of second primary cancer (SCP) under the effect of some new androgen receptor pathway inhibitors (ARPIs), especially enzalutamide (ENZ). ...
Use and misuse of domperidone in patients living with Parkinson disease in France [0.03%]
法国帕金森病患者正确与错误使用多潘立酮
Edouard Januel,Jean Christophe Corvol,Philippe Remy et al.
Edouard Januel et al.
Context: After observing increased sudden death risk associated with domperidone use, the European Medicines Agency (EMA) imposed usage restrictions in 2014, limiting age (≤60 years), daily dose (≤30 mg/day), and durati...
Multicenter Study
Fundamental & clinical pharmacology. 2025 Apr;39(2):e70002. DOI:10.1111/fcp.70002 2025
Adrenaline enhances nociceptive and motor blockades by intrathecal carteolol and oxprenolol in rats [0.03%]
肾上腺素增强intrathecal 胺替洛尔和氧普洛尔在大鼠的痛觉和运动阻滞作用
Chong-Chi Chiu,Kuo-Sheng Liu,Chieh-Yu Liu et al.
Chong-Chi Chiu et al.
Background: This study examined the effects of beta-blockers and the combination of carteolol/oxprenolol with epinephrine on spinal nociceptive and motor blockades and compared them with propranolol. ...
Comparative Study
Fundamental & clinical pharmacology. 2025 Apr;39(2):e70003. DOI:10.1111/fcp.70003 2025