Fluvoxamine Attenuates Liver Injury in Lipopolysaccharide-Induced Sepsis: Via Nrf2/HO-1 Pathway [0.03%]
氟伏沙明减轻脂多糖诱导的脓毒症肝损伤：通过Nrf2/HO-1通路实现
Rahime Aslankoc,Ozlem Ozmen,Pınar Karabacak et al.
Rahime Aslankoc et al.
The search for new treatments for sepsis is a pivotal subject of survey owing to the high mortality of sepsis. Sepsis can cause serious injury to many vital organs, including the liver. This study investigated the potential therapeutic impa...
Cannabinoids and Adverse Convulsive Effects: A Pharmacovigilance and Addictovigilance Analysis of Cases Reported in France [0.03%]
大麻素与不良的惊厥作用：法国报告案例的药物警戒和成瘾预警分析
Marie-Laure Laroche,Marion Labetoulle,Emilie Jouanjus et al.
Marie-Laure Laroche et al.
Background: Seizures after the use of cannabinoids are reported, but no precise descriptions of the characteristics of subjects and factors that may trigger seizures are available. ...
Hydrogen Sulfide Treatment Enhanced Paclitaxel's Anticancer Effect on the ID8 Murine Epithelial Ovarian Cancer Cell Line [0.03%]
氢硫酸盐处理增强帕利昔尔对ID8小鼠上皮性卵巢癌细胞系的抗癌作用
Gökçe Sevim Öztürk Fincan,Ayşe Kübra Kibar Güzin,Atiye Seda Yar Sağlam
Gökçe Sevim Öztürk Fincan
Background: Paclitaxel is a potent agent against ovarian cancer. Hydrogen sulfide (H2S) is of particular interest in cancer treatment research. It is known that H2S has apoptotic and antiproliferative effects. ...
Luc Zimmer,Alain Gardier
Luc Zimmer
Relapse and New-Onset of Autoimmune or Inflammatory Diseases Following Vaccination With SPIKEVAX: Pharmacovigilance Overview From the French Spontaneous Reported System [0.03%]
基于法国自发报告系统的 Spikevax 疫苗后自身免疫或炎症性疾病复发和新发的药物警戒概述
Lucie Vettoretti,Célia Bouaskeur,Nadine Magy-Bertrand et al.
Lucie Vettoretti et al.
Background: COVID-19 vaccination raises questions in patients with autoimmune or inflammatory diseases (AIID), not included in clinical trials. Concern exists about the risk of activating the immune system or worsening th...
Angiotensin II Type 1 Receptor Blocker Usage Prevents Oxidative Stress and Muscle Dysfunction in HIV [0.03%]
血管紧张素Ⅱ受体阻断剂使用可防止HIV患者的氧化应激和肌细胞功能障碍
Rafael Deminice,Paola Sanches Cella,Ana Lúcia Borsari et al.
Rafael Deminice et al.
Background: We aimed to elucidate the role of Angiotensin II type 1 receptor (AT1R) blocker usage in muscle wasting and dysfunction related to HIV. Resear...
Vitamin D lacks efficacy: A re-analysis of a systematic review using the REB method [0.03%]
维生素D无效性的一个再分析：使用REB方法对系统评价的再分析结果表明维生素D并无效果
Vanessa Bironneau,Marie Laura Palamede,Elodie Charuel et al.
Vanessa Bironneau et al.
Background: The results of randomized controlled trials (RCTs) evaluating the effect of vitamin D on the prevention of acute respiratory tract infections (RTIs) are conflicting. The aim of this study was to assess the lev...
Therapeutic Potential of 3-(4-Chlorophenyl)-4-(2-Hydroxyphenyl) 1,3-Oxazetidin-2-One in STZ-Induced Diabetic Neuropathic Pain in Rats [0.03%]
3-(4-氯苯基)-4-(2-羟基苯基)-1,3-恶唑烷二酮对链脲佐菌素诱导的糖尿病神经病理性疼痛的大鼠的治疗潜力研究
Manpreet Kaur,Dhruva Kumar,Navjeet Kaur et al.
Manpreet Kaur et al.
The present study was designed to investigate the therapeutic potential of oxazetidin-2-one derivatives in a rat model of streptozotocin (STZ)-induced diabetic neuropathic pain. A single dose of STZ (i.e., 75 mg/kg; i.p.) was administered t...
ABCB1, SLC22A1, COMT, and OPRM1 genotypes: Study of their influence on plasma methadone levels and clinical response to methadone maintenance treatment in opioid use disorder [0.03%]
ABCB1，SLC22A1，COMT和OPRM1基因多态性对阿片类物质使用障碍美沙酮维持治疗血药浓度及临床疗效的影响研究
Abd El Kader Ait Tayeb,Edouard-Jules Laforgue,Benoit Schreck et al.
Abd El Kader Ait Tayeb et al.
Background: Opioid use disorder (OUD) is an emerging and global public health concern, and its management remains inadequate, notably due to a lack of biomarkers, except for the CYP2B6 genetic polymorphisms. ...
Insights into nanostructured lipid carriers of etoricoxib for mitigating radiation-induced lung inflammation and exploring anti-inflammatory mechanisms in rats [0.03%]
依托考昔纳米结构脂质载体缓解放射致肺炎及抗炎机制研究
Sahar Khateeb,Amal I Hassan
Sahar Khateeb
Background: Radiation exposure can cause inflammation, which etoricoxib (ET), an anti-inflammatory drug, could potentially mitigate. Objective: ...