Leveraging Fiber Photometry to Decipher Neural Circuits Underlying Anxiety in Mice [0.03%]
利用纤维光度计解码小鼠焦虑相关神经环路的功能性信号变化
Salma R Abdennebi,Nour El Haya Touihri,Emmanuelle Corruble et al.
Salma R Abdennebi et al.
Anxiety disorders rank among the most prevalent mental health conditions worldwide, significantly affecting patients' lives. They are frequently comorbid with other psychiatric disorders, often exacerbating their severity. Current pharmacol...
Repurposing Asparaginase Therapy to Target Cisplatin-Resistant Cancer Cells [0.03%]
异丙酚麻醉对ICU病人急性呼吸窘迫综合征的影响的meta分析研究
Jiantao Wang,Nasim Pouryaghoub,Robert Strauss et al.
Jiantao Wang et al.
Background: Cisplatin and its derivatives remain a cornerstone in the treatment of solid malignancies. Resistance is a major factor limiting their clinical utility. ...
Tamsulosin Attenuates Cardiac Hypertrophy via Integrin-Linked Kinase: Possible Mechanisms [0.03%]
坦索罗辛通过整合素连接激酶抑制心脏肥厚及可能机制研究
Asma S Alonazi,Anfal F Bin Dayel,Hetoun A Alomer et al.
Asma S Alonazi et al.
Background: Cardiac hypertrophy often transits into heart failure. Angiogenesis significantly affects the pathogenesis of cardiac hypertrophy. Cytoplasmic integrin-linked kinase (ILK) regulates cardiac angiogenesis by sti...
Correction to "ABCB1, SLC22A1, COMT, and OPRM1 Genotypes: Study of Their Influence on Plasma Methadone Levels and Clinical Response to Methadone Maintenance Treatment in Opioid Use Disorder" [0.03%]
有关于“ABCB1，SLC22A1，COMT和OPRM1基因型：对阿片类药物使用障碍患者血浆美沙酮浓度及美沙酮维持治疗临床疗效的影响研究”的勘误
Published Erratum
Fundamental & clinical pharmacology. 2025;39(5):e20010. DOI:10.1111/fcp.70040 2025
Effects of Atorvastatin and Gemfibrozil on Mice Corpus Cavernosum In Vitro [0.03%]
阿托伐他汀和吉非罗齐对小鼠阴茎海绵体平滑肌细胞的作用机制不同
Ilknur Erkoseoglu,Mine Kadioglu Duman,Sabri Murat Kesim et al.
Ilknur Erkoseoglu et al.
Most of the drugs used in the treatment of cardiovascular diseases cause unfavorable effects on erectile functions. In this study, the effect of atorvastatin and gemfibrozil, which have different hypolipidemic mechanisms of action, on the e...
Drug Exposure in Chronic Kidney Disease: It Is Not Just About the Glomerular Filtration Rate [0.03%]
慢性肾脏疾病中的药物暴露：它不仅仅关乎肾小球滤过率
Sophie Liabeuf,Jessica Berdougo-Tritz,Lucie Augey et al.
Sophie Liabeuf et al.
Chronic kidney disease (CKD) affects over 10% of the world's population and is associated with high morbidity and mortality rates. The management of CKD is complex; CKD alters drug pharmacokinetics and pharmacodynamics and further complicat...
Psilocybin as Transformative Fast-Acting Antidepressant: Pharmacological Properties and Molecular Mechanisms [0.03%]
裸盖菇素作为快速起效的抗抑郁药：药理特性及分子机制
Makiath Adebo,Mathilda Bonnet,Ons Laouej et al.
Makiath Adebo et al.
In the 1950s-60s, serotonergic psychedelic drugs were studied as potential adjuvants to psychotherapy to treat addiction and alcoholism. However, starting in the 70s, preclinical and clinical studies on psychedelics stopped for decades beca...
Safety of Proton Pump Inhibitor in Paediatrics: A Study Based on EudraVigilance Data [0.03%]
基于EudraVigilance数据库儿科 proton pump inhibitor 用药安全性的研究
Greta Santi Laurini,Victoria Nikitina,Nicola Montanaro et al.
Greta Santi Laurini et al.
Background and objectives: Despite limited paediatric approvals, the use of proton pump inhibitors (PPIs) among children has increased in recent years, and concerns have arisen about their safety, including the risk of al...
DPD Ultra-Rapid Metabolizer Status and Efficacy of 5-Fluorouracil Treatment: A Real-World Study [0.03%]
DPD超快代谢型状态与5-氟尿嘧啶治疗疗效的相关性：一项真实世界研究
Govind Kallee,Gérard Milano,Florence Duffaud et al.
Govind Kallee et al.
Background: Anticancer drug 5FU is extensively metabolized by dihydropyrimidine dehydrogenase (DPD), an enzyme with high interindividual variability. Poor metabolizer (PM, i.e., DPD deficient) patients are at risk of life...
Effects of FECH Gene Polymorphisms and Serum Ferrochelatase Levels on Antituberculosis Drug-Induced Liver Injury in China [0.03%]
中国个体中超氧化物歧化酶基因多态性及血清金属硫蛋白水平对结核病药物肝毒性的效应研究
Jingru Cheng,Nannan Wang,Ruina Chen et al.
Jingru Cheng et al.
Objectives: The pathogenic mechanism of antituberculosis drug-induced liver injury (ATLI) has not been elucidated. This study aimed to investigate the effects of FECH genetic polymorphisms and serum ferrochelatase levels ...