Yves Fromes
Yves Fromes
Investigation of the Immune System Effects of Desloratadine on Lipopolysaccharide-Stimulated Mammalian Macrophage Cells [0.03%]
描述转拉太丁对脂多糖刺激的哺乳动物巨噬细胞免疫系统影响的研究
Batuhan Yurtseven,Ömer Mete Başkan,Esra Aydemir et al.
Batuhan Yurtseven et al.
Background: Neuroimmune interactions are central to inflammatory and neurological disorders. Desloratadine (DES), a second-generation H1 antihistamine, has been suggested to exert immunomodulatory effects, yet its impact ...
Sex and Age Differences in Suspected Bleeding Reporting With Acetyl Salicylic Acid: A Descriptive Study in the Global Pharmacovigilance Database, Vigibase [0.03%]
一项关于全球药物警戒数据库VigiBase中阿司匹林疑似出血报告的性别的差异描述性研究
Jean-Louis Montastruc,Alessandra Bura-Rivière
Jean-Louis Montastruc
Objective: The present study was performed to investigate putative sex differences in the reporting of acetyl salicylic acid (ASA)-related bleeding in the global pharmacovigilance database. ...
Impact of Direct Oral Anticoagulant Uptake on Hospitalizations for Stroke/Transient Ischemic Attack, Intracranial Hemorrhage, and Gastrointestinal Bleeding in Individuals With Atrial Fibrillation: A Population-Based Study [0.03%]
直接口服抗凝药在房颤患者中的使用对卒中/短暂性脑缺血发作、颅内出血和消化道出血住院风险的影响：基于人群的队列研究
Tony Antoniou,Daniel McCormack,Tianru Wang et al.
Tony Antoniou et al.
Background: Direct-acting oral anticoagulants (DOACs) have largely replaced warfarin for stroke prevention in patients with atrial fibrillation, yet their population-level impact on health outcomes and costs remains uncle...
Topical Probiotic Therapy Reduces Chemotherapy-Induced Oral Mucositis: Preclinical Evaluation in a Rat Model [0.03%]
topical probiotics 有助于减轻化疗诱导的口腔粘膜炎：大鼠模型的临床前评估
Buse Kose Demirezen,Eren Demirpolat,Arzu Yay et al.
Buse Kose Demirezen et al.
Background: Oral mucositis (OM) is a debilitating complication of chemotherapy and radiotherapy, characterized by painful ulcerations and inflammation of the oral mucosa. Current treatments provide limited efficacy and of...
Acute or Chronic β-Caryophyllene Systemic Administration in Healthy Adult Male Mice Does Not Modulate Anxiety-Like Extinction Behavior Induced by Subsequent Re-Exposure to 3D Maze [0.03%]
急性或慢性千层花二萜醇系统给药对健康成年雄性小鼠随后重新暴露于三维迷宫诱发的类焦虑行为消退无调节作用
Rayan Fidel Martins Monteiro,Marcos Vinícius Lebrego Nascimento,Klinsmann Thiago Lima et al.
Rayan Fidel Martins Monteiro et al.
Pharmacotherapy for major anxiety disorders continues to present dangerous side effects, complicating precise treatment choices for each patient. In this context, β-caryophyllene (BCP), a selective agonist of the cannabinoid type II recept...
Cholesterol Intake and Atorvastatin Modulate SCD1 and ELOVL6 in Rat Retroperitoneal Adipose Tissue [0.03%]
胆固醇摄入和阿托伐他汀调节大鼠腹膜后脂肪组织中的硬脂酰辅酶A脱氢酶1和延伸链长度蛋白6
Jagoda Drag,Marek Szlosarczyk,Anna Gawedzka et al.
Jagoda Drag et al.
Background: Stearoyl-CoA desaturase 1 (SCD1) and elongase 6 (ELOVL6) are key enzymes in the synthesis of monounsaturated fatty acids (MUFA). Gene expression for SCD1 and ELOVL6 is high in the white adipose tissue (WAT) an...
Nebivolol Mitigates the Pro-Oxidative and Pro-Inflammatory Effects of Cyclophosphamide in the Heart [0.03%]
奈倍地洛缓解环磷酰胺对心脏的促氧化和促炎症作用
Barbara M Marchetti,Thales M H Dourado,Gustavo F Pimenta et al.
Barbara M Marchetti et al.
Cyclophosphamide (CP) is an alkylating agent commonly used to treat malignant conditions. However, CP is associated with various adverse effects, one of which is cardiotoxicity. To minimize this toxicity, a common clinical strategy involves...
Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies [0.03%]
他汀类药物作为抗真菌剂：药物再定位和纳米技术驱动的输送策略综述
Dominique Mesquita E Silva,Laís de Souza Lacerda,Andrea de Souza Andrioli et al.
Dominique Mesquita E Silva et al.
This review highlights the integration of drug repurposing and nanotechnology-driven delivery strategies as innovative approaches to enhance the antifungal activity of statins against mucosal candidiasis, providing a framework for future tr...
No Impact of Vancomycin MIC, AUC, or AUC/MIC in Enterococcus faecium Bacteremia [0.03%]
万古霉素MIC、AUC或AUC/MIC对肠球菌血流感染预后无影响
Anne Limelette,Thibaut Tromeur,Rami Rhaiem et al.
Anne Limelette et al.
Background: There is no clear pharmacokinetic and pharmacodynamic (PK/PD) target during vancomycin-susceptible Enterococcus faecium bacteremia (EFB). Obje...