Preventive Effects of trans-4-Methoxy-β-nitrostyrene on Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats [0.03%]
反式-4-甲氧基-β-亚硝基 styrene预防单端孢霉烯毒素诱导的大鼠肺动脉高压的作用
Matyelle Jussára Rodrigues-Silva,Rodrigo José Bezerra de Siqueira,Karoline Gonzaga-Costa et al.
Matyelle Jussára Rodrigues-Silva et al.
Background: The soluble guanylate cyclase (sGC)/GMPc pathway plays an important in pulmonary arterial hypertension (PAH). Objective: We...
Targeting Neuroinflammation in Alzheimer's Disease: Repurposed Nucleoside Reverse Transcriptase Inhibitors and the Therapeutic Potential of Kamuvudine-9 [0.03%]
针对阿尔茨海默病神经炎症的再定位核苷逆转录酶抑制剂及Kamuvudine-9的治疗潜力
Mariyam Hussain,Mohammad Ikram,Divya Vohora
Mariyam Hussain
Alzheimer's disease (AD) is a progressive neurological illness that causes cognitive deterioration. Current medications only help with the symptoms to a limited extent. Over the past decade, nucleoside reverse transcriptase inhibitors (NRTI...
Non-Pulmonary Mechanisms of Action of Ambroxol in In Vivo Experimental Models: a Systematic Review [0.03%]
氨溴索在体内实验模型中的非肺部作用机制：系统性回顾
Michelline Joana Tenório Albuquerque Madruga Mesquita,Anne Caroline Silva Nogueira da Cruz,Rafael de Abreu Lima et al.
Michelline Joana Tenório Albuquerque Madruga Mesquita et al.
Background: Repositioning offers a cost-effective approach to discovering new therapeutic applications for existing medications. Ambroxol, primarily used as a mucolytic for respiratory diseases, has demonstrated anti-infl...
Medical Cannabis Use in France: An Observational Safety Study Based on the RECANN Registry and the Pharmacovigilance/Addictovigilance System From 2021 to 2024 [0.03%]
2021至2024年基于RECANN登记册和药物警戒/成瘾监测系统的法国医疗用大麻使用观察性安全性研究
Cécile Chevallier,Anne Batisse,Emilie Monzon et al.
Cécile Chevallier et al.
Introduction: The French National Agency for Medicines and Health Products Safety implemented in 2021 a nationwide experimentation for medical cannabis (MC), designed to assess the feasibility of implementing a new public...
Observational Study
Fundamental & clinical pharmacology. 2026 Mar;40(2):e70074. DOI:10.1111/fcp.70074 2026
Immunomodulatory Effects of Hyoscine Butylbromide on Mammalian Macrophages [0.03%]
溴化丁基东莨菪碱对哺乳动物巨噬细胞的免疫调节作用
Begüm Rana Atalay,Batuhan Yurtseven,Ebru Akbaba et al.
Begüm Rana Atalay et al.
Hyoscine butylbromide (HB), popularly known as Buscopan, is a common anticholinergic antispasmodic used worldwide for gastrointestinal disorders. While the interaction between the cholinergic system and immunity is increasingly recognized, ...
SGLT-2 Inhibitors Use in Hospitalized Patients in France: A Cross-Sectional Study [0.03%]
法国住院患者使用SGLT-2抑制剂的现状：一项横断面研究
Maxime Demourgues,Julien Bezin,Romain Griffier et al.
Maxime Demourgues et al.
Background: Sodium glucose co-transporter type 2 inhibitors (SGLT2i) were initially developed as glucose-lowering drugs for diabetic patients. A few years after their market authorization in Europe, their indications were...
Blandine Bertin,Valentine Lacotte,Jean-Luc Cracowski et al.
Blandine Bertin et al.
Background: Statin-induced liver injury is frequent and usually not severe. The aim of the present study was to describe the safety of statin rechallenge after atorvastatin-induced liver injury because it is poorly docume...
Real-World Use of Dupilumab in Atopic Dermatitis: Observational Study Results Linked to SNDS [0.03%]
杜普利尤单抗治疗特应性皮炎的真实世界使用情况：与国家药品数据库系统相连接的观察性研究结果
Alain Dupuy,Anne-Claire Fougerousse,Pierre-André Bécherel et al.
Alain Dupuy et al.
Background: Dupilumab is reimbursed in France for adult patients with moderate-to-severe atopic dermatitis (AD), in cases of failure, intolerance or contraindication to cyclosporin A (CsA). The French National Authority f...
Observational Study
Fundamental & clinical pharmacology. 2026 Mar;40(2):e70070. DOI:10.1111/fcp.70070 2026
JAK Inhibitors and Memory Impairment: Disproportionality Analyses in the WHO Global Pharmacovigilance Database, VigiBase [0.03%]
全球药监数据库VigiBase中Janus激酶抑制剂与记忆损害的 disproportionality 分析
Marilou Duboëlle,Adriano Lercara,Yves-Marie Pers et al.
Marilou Duboëlle et al.
Background: Chronic inflammation is involved in various mechanisms of memory impairment (MI). Although Janus kinase inhibitors (JAKi), which inhibit cytokine-induced JAK-STAT pathway, could theoretically protect against M...