Monitoring of Clinics That Use Direct-to-Consumer Advertising for Off-Label Ketamine in the New York Metropolitan Area: A Cross-Sectional Systematic Web Search [0.03%]
纽约大都会地区使用直接面向消费者广告进行盐酸氯胺酮超说明书宣传的门诊监测：横断面系统化网络搜索
Nina Abukahok,Steven Lawrence,Samrachana Adhikari et al.
Nina Abukahok et al.
Background: Ketamine is increasingly prescribed in an off-label manner to treat psychiatric disorders, raising concerns about direct-to-consumer advertising and the proliferation of clinics offering ketamine for at-home u...
A Semi-Isolation Housing Paradigm Affects Anxiety, Ethanol Intake, and the Gut Microbiota in Adult Male C57BL/6JRj Mice [0.03%]
半隔离饲养模式影响雄性C57BL/6JR小鼠的焦虑行为、酒精摄入和肠道微生物菌群
Anish Nusrat,Bienvenue Koffi,Yann Pelloux et al.
Anish Nusrat et al.
Background: There is a complex link between environmental factors, anxiety levels, and ethanol consumption. Social conditions such as loneliness, peer influence, and housing environment shape drinking behaviors and mental...
Effect of a Single Oral Dose of Dexamphetamine or Zolpidem on Attention and Reaction Time in Healthy Men [0.03%]
单一口服剂量的达莫凡特明或唑吡坦对健康男性注意力和反应时间的影响
Veronika Pfoser-Poschacher,Michael Wolf,Michaela Bayerle-Eder et al.
Veronika Pfoser-Poschacher et al.
Psychotropic medicines are known to impair cognitive function acutely, but the specific effects of individual substances remain underexplored. This study investigates the effects of dexamphetamine and zolpidem on cognitive performance to qu...
Randomized Controlled Trial
Fundamental & clinical pharmacology. 2026 May;40(3):e70092. DOI:10.1111/fcp.70092 2026
Repurposing Cimetidine as a Therapeutic Candidate for Irritable Bowel Syndrome in a Rat Model [0.03%]
将西咪替丁重新定位为 irritable bowel syndrome 模型中的一种潜在治疗药物候选者
Tsukasa Nozu,Saori Miyagishi,Masatomo Ishioh et al.
Tsukasa Nozu et al.
Background: Visceral hypersensitivity and impaired intestinal barrier function are hallmark features of irritable bowel syndrome (IBS), linked to activation of corticotropin-releasing factor (CRF), Toll-like receptor 4 (T...
Alogliptin Delays the Healing of Traumatic Oral Ulcers in the Buccal Mucosa of Wistar Rats [0.03%]
阿格列汀延迟Wistar大鼠颊粘膜创伤性口腔溃疡的愈合
Maria Imaculada de Queiroz Rodrigues,Joyce Ohana de Lima Martins,Debora de Souza Collares Maia Castelo-Branco et al.
Maria Imaculada de Queiroz Rodrigues et al.
Objective: The objective of this study is to evaluate the influence of alogliptin treatment on the healing process of traumatic oral ulcers. Methods: ...
Dexamethasone-Mediated Regulation of CYP3A4 and UGTs in Human Hepatoma HuH-7 Cells [0.03%]
人工合成皮质激素调节人体肝细胞癌HuH-7中CYP3A4和UGTs的作用机制研究
Hana Yu,Song Hee Lee,Ji Hyeon Kim et al.
Hana Yu et al.
Background: The application of human hepatic cell lines to early drug discovery and development instead of human primary hepatocytes (HPHs) has been limited because of the low level of drug-metabolizing enzymes (DMEs). ...
Dual Targeting of Akt and MAPK Pathways With Capivasertib and B-Raf Inhibitors Synergistically Suppresses Tumor Growth in B-Raf-Mutated Melanoma Models [0.03%]
双靶向AKT和MAPK途径的卡皮瓦塞替布和B-Raf抑制剂协同抑制B-Raf突变型黑色素瘤模型中的肿瘤生长
Jun Tang,Lingling Zhao,Yuanyuan Zhu et al.
Jun Tang et al.
Resistance to B-Raf inhibitors in melanoma poses a significant challenge to effective treatment. This study investigates the synergistic effects of capivasertib, an Akt pathway inhibitor, in combination with B-Raf inhibitors (vemurafenib an...
Iohexol Clearance and Kidney Transplantation: Determinants of Its Variation in Living Kidney Donors One Year After Donation and Impact on Glomerular Filtration Rate Gain in Kidney Recipients [0.03%]
碘海醇清除率与肾脏移植：一年后供者变化的影响因素及其对受者肾小球滤过率恢复的影响研究
Capucine Arrivé,Nathan Baran,Julia Tonini et al.
Capucine Arrivé et al.
Background: Iohexol clearance (mGFRioh) is a marker of choice for measuring glomerular filtration rate (GFR) in potential living kidney donors. Objectives...
Evaluating the Environmental Impact of Clinical Research: A Full Life Cycle Analysis of a French Academic Randomised Clinical Trial [0.03%]
临床研究的环境影响评估——法国一项学术随机临床试验的全生命周期分析
Claire Fougerou-Leurent,Louise Forteau,Maëlle Perrot-Loyer et al.
Claire Fougerou-Leurent et al.
Climate change poses the greatest threat to human health in the 21st century. The healthcare sector contributes approximately 5% of global greenhouse gas emissions and has a significant environmental impact. Although clinical trials are cru...
Randomized Controlled Trial
Fundamental & clinical pharmacology. 2026 May;40(3):e70086. DOI:10.1111/fcp.70086 2026
Factors Associated With Cocaine Use Disorder: Results From the French Nationwide Repeated Cross-Sectional OPPIDUM Study (2019-2023) [0.03%]
法国全国重复横断面OPPIDUM研究（2019-2023）中与可卡因使用障碍相关的因素结果报告
Zenab Alhamidi,Clémence Lacroix,Elisabeth Jouve et al.
Zenab Alhamidi et al.
Cocaine use has increased both globally and nationally. This trend is accompanied by a rise in clinical complications. The objective of our study was to identify factors observed to be associated with cocaine use disorder, using data from t...
Multicenter Study
Fundamental & clinical pharmacology. 2026 May;40(3):e70081. DOI:10.1111/fcp.70081 2026