Antisecretory effect of prescribed appetite stimulator drug cyproheptadine in rat intestine [0.03%]
食欲刺激药物氮卓斯丁的抗分泌作用机制研究
Bouchra Meddah,Nicolas Limas-Nzouzi,Godefroy Mamadou et al.
Bouchra Meddah et al.
Cyproheptadine (Cph) is an antiserotoninergic and antihistaminergic agent with alpha-blocking activity and central sedative effect. Cph has been found to be effective in stimulating appetite, but to our knowledge, its direct effects on the ...
Single and repeated sevoflurane or desflurane exposure does not impair spatial memory performance of young adult mice [0.03%]
单次和重复吸入七氟烷或地氟醚不影响年轻小鼠的空间记忆性能
Alper Kilicaslan,Muaz Belviranli,Nilsel Okudan et al.
Alper Kilicaslan et al.
Volatile anesthetics are known to disturb the spatial memory in aged rodents, but there is insufficient information on their effects on young adult rodents. The aim of this study was to compare the effects of single and repeated exposure to...
Comparative Study
Fundamental & clinical pharmacology. 2013 Dec;27(6):641-9. DOI:10.1111/fcp.12027 2013
Interactions between angiotensin AT1 receptor antagonists and second-generation antiepileptic drugs in the test of maximal electroshock [0.03%]
血管紧张素AT1受体拮抗剂与第二代抗癫痫药在电休克实验中的相互作用
Krzysztof Łukawski,Agnieszka Janowska,Tomasz Jakubus et al.
Krzysztof Łukawski et al.
The anticonvulsant activity of angiotensin AT1 receptor antagonists, losartan (2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'(1H-tetrazol-5-yl)-biphenil-4-yl)methyl]imidazole) and telmisartan (49-[(1,49-dimethyl-29-propyl[2,69-bi-1H-benzimidazo]...
OPPIDUM surveillance program: 20 years of information on drug abuse in France [0.03%]
法国药物滥用监测系统(OPPIDUM)二十年变迁
Elisabeth Frauger,Christophe Moracchini,Reynald Le Boisselier et al.
Elisabeth Frauger et al.
It is important to assess drug abuse liability in 'real life' using different surveillance systems. Some are based on specific population surveys, such as individuals with drug abuse or dependence, or under opiate maintenance treatment, bec...
Effect of simvastatin on the antihypertensive activity of losartan in hypertensive hypercholesterolemic animals and patients: role of nitric oxide, oxidative stress, and high-sensitivity C-reactive protein [0.03%]
辛伐他汀对高血压高胆固醇动物及患者降压药物洛萨坦药效的影响：一氧化氮、氧化应激和超敏C反应蛋白的作用
Ahmed O Abdel-Zaher,Alaa Eldin A Elkoussi,Lotfy H Abudahab et al.
Ahmed O Abdel-Zaher et al.
This study investigated whether simvastatin has antihypertensive activity and can enhance the antihypertensive effect of losartan in hypertensive hypercholesterolemic animals and patients. Hypertension and hypercholesterolemia were induced ...
The antimanic-like effect of phenytoin and carbamazepine on methylphenidate-induced hyperlocomotion: role of voltage-gated sodium channels [0.03%]
苯妥英和卡马西普通过电压门控钠通道对甲基苯丙胺诱导的超常运动产生抗躁狂效应：电压门控钠通道的作用
Denise A G Tonelli,Marcela Pereira,Isadora P Siba et al.
Denise A G Tonelli et al.
The objective of this study was to verify whether phenytoin modifies methylphenidate-induced hyperlocomotion, an animal model for screening antimanic-like drugs, and also evaluate the effect of veratrine, a voltage-gated sodium channel open...
Comparative Study
Fundamental & clinical pharmacology. 2013 Dec;27(6):650-5. DOI:10.1111/fcp.12022 2013
Low-temperature plasmas at atmospheric pressure: toward new pharmaceutical treatments in medicine [0.03%]
低温大气压等离子体：医学新药物治疗的理想选择
Mohammed Yousfi,Nofel Merbahi,Atul Pathak et al.
Mohammed Yousfi et al.
This article concerns a new field covered by low-temperature plasmas at atmospheric pressure for medical treatments. This is based on the very attractive possibility to tune and design plasmas as possible pharmaceutical products using selec...
Investigation of drug-drug interactions between clopidogrel and fluoxetine [0.03%]
氯吡格雷与氟西汀药物相互作用的研充
Xavier Delavenne,Marion Magnin,Thierry Basset et al.
Xavier Delavenne et al.
Drug-drug interactions may contribute to the variability of the response of clopidogrel. Several hypotheses have been proposed concerning the potential modification of clopidogrel pharmacokinetics and pharmacodynamics by fluoxetine. This op...
Randomized Controlled Trial
Fundamental & clinical pharmacology. 2013 Dec;27(6):683-9. DOI:10.1111/fcp.12021 2013
Paeonol suppresses lipopolysaccharide-induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock [0.03%]
苯乙酮酚通过抑制巨噬细胞内脂多糖诱导的炎症因子分泌及在小鼠体内抵抗内毒素致死性休克中发挥作用
Na Chen,Dianfeng Liu,Lanan Wassy Soromou et al.
Na Chen et al.
Paeonol (2'-hydroxy-4'-methoxyacetophenone) is the main phenolic compound of the radix of Paeonia suffruticosa which has been used as traditional Chinese medicine. In this study, we primarily investigated the anti-inflammatory effects and t...
Exogenous NAD(+) supplementation protects H9c2 cardiac myoblasts against hypoxia/reoxygenation injury via Sirt1-p53 pathway [0.03%]
外源性NAD(+)通过Sirt1-p53信号通路保护H9c2心肌细胞免受缺氧/复氧损伤
Ling Liu,Ping Wang,Xinwei Liu et al.
Ling Liu et al.
Nicotinamide adenine dinucleotide (NAD(+) ) not only transfers electrons in mitochondrial respiration, but also acts as an indispensable cosubstrate for Sirt1, the class III histone/nonhistone deacetylase. However, NAD(+) is depleted in myo...