Severe fluoropyrimidine toxicity in older adults with cancer with DPYD wild type [0.03%]
DPYD基因型为野生型的癌症老年患者的氟尿嘧啶严重毒性反应
Edwin Brokaar,Jonathan Knikman,Loes Visser et al.
Edwin Brokaar et al.
Background: Despite the implementation of DPYD genotype-guided dosing, approximately 1 in 3 patients receiving fluoropyrimidine-containing chemotherapy continues to experience severe toxicity. While clinical studies have ...
Population pharmacokinetics of sivelestat in Chinese patients with severe pneumonia [0.03%]
西维来司他在严重肺炎中国患者中的群体药代动力学特征
Xiaolin Zhang,Huiliang Hu,Ziran Li et al.
Xiaolin Zhang et al.
Background: Sivelestat sodium, an inhibitor of neutrophil elastase, was broadly used in the treatment of severe pneumonia. However, the pharmacokinetic (PK) characteristics of sivelestat in patients with severe pneumonia ...
Real-world interpatient variability in the pharmacokinetics of levetiracetam [0.03%]
左乙拉西坦药代动力学的院际差异性研究
Alina Chykharivska,Leonid Kagan,Mary Wagner et al.
Alina Chykharivska et al.
Background: Levetiracetam (LEV) is an antiepileptic drug (AED) used to treat a variety of seizures in adult and pediatric populations. It is an ideal AED due to its favorable pharmacokinetic (PK) and pharmacodynamic profi...
RETRACTION: L. Chen, R. Shi, X. She, C. Gu, L. Chong, L. Zhang, R. Li, "Mineralocorticoid Receptor Antagonist-Mediated Cognitive Improvement In A Mouse Model Of Alzheimer's Type: Possible Involvement Of BDNF-H2S-Nrf2 Signaling," Fundamental & Clinical Pharmacology 34, no. 6 (2020): 697-707, 10.1111/fcp.12576 [0.03%]
撤稿：L. Chen，R. Shi，X. She，C. Gu，L. Chong，L. Zhang，R. Li《矿物皮质激素受体拮抗剂介导的认知改善在阿尔茨海默型小鼠模型中的作用：BDNF-H2S-Nrf2信号可能参与其中》[34(6):697-707]
Repurposing bosentan as an anticancer agent: EGFR/ERK/c-Jun modulation inhibits NSCLC tumor growth [0.03%]
曲格列松的抗癌作用再利用研究：EGFR/ERK/c-Jun调节抑制NSCLC肿瘤生长
Marwa M Khalaf,Marina N Malak,Tariq G Alsahli et al.
Marwa M Khalaf et al.
Drug repurposing of well-established drugs to be targeted against lung cancer has been a promising strategy. Bosentan is an endothelin 1 (ET-1) blocker widely used in pulmonary hypertension. The current experiment intends to inspect the ant...
Fluoxetine-induced downregulation of circMap2k1 signaling cascade to improve neurological function after ischemic stroke [0.03%]
氟西汀通过下调circMap2k1信号级联改善缺血性卒中后神经功能结局
Langtao He,Hui Zhang,Jian Deng et al.
Langtao He et al.
Background: Ischemic stroke (IS) is known for its high incidence, disability, and mortality, and there is an urgent need to investigate the pathophysiological mechanisms and develop novel treatment strategies. ...
Lars Petter Jordheim
Lars Petter Jordheim
A novel naphthylchalcone ([E]-4-(3-[naphthalen-2-yl]-3-oxoprop-1-en-1-yl) induces intrinsic and extrinsic apoptosis in human acute leukemia cell lines [0.03%]
新的萘基查尔康茋（[E]-4-（3-[萘-2-基]-3-氧代丙-1-烯-1-基）在人急性白血病细胞系中诱导固有和外在凋亡
Amanda V Jacques,Natália M Stefanes,Laura O Walter et al.
Amanda V Jacques et al.
Background: Chalcones have been described in the literature as promising antineoplastic compounds. Objectives: Therefore, the objective...
Long-term evaluation of rheumatoid arthritis activity with erythrocyte methotrexate-polyglutamate 3 [0.03%]
红细胞叶酸聚谷氨酸3长期评估类风湿关节炎活动度
Jean Escal,Marion Poudret,Sophie Hodin et al.
Jean Escal et al.
Background: Methotrexate (MTX) is the first-line treatment for Rheumatoid Arthritis (RA), yet 30%-50% of RA patients develop resistance to MTX, which can manifest several years after treatment initiation. ...
Body mass index affects imatinib exposure: Real-world evidence from TDM with adaptive dosing [0.03%]
体重指数影响伊马替尼暴露量：来自药物浓度监测的现实证据
Paul Maroselli,Raphaelle Fanciullino,Julien Colle et al.
Paul Maroselli et al.
Background: Imatinib is the treatment of elderly or frail patients with chronic myeloid leukemia (CML). Trough levels of around 1000 ng/ml are considered as the target exposure. ...