Exploring the Molecular Mechanisms of SB216763 in the Therapeutic Intervention of Pulmonary Fibrosis Based on Macrophage Functional Plasticity [0.03%]
基于巨噬细胞功能可塑性探讨SB216763干预肺纤维化的分子机制
Yunuo Zhou,Pei Zhou,Jianhong Qi
Yunuo Zhou
Background: SB216763 has demonstrated efficacy in treating pulmonary fibrosis in animal models, but its underlying mechanisms remain poorly understood. This study used network pharmacology, molecular docking, and molecula...
When Side Effects Become Therapies: A Mechanistic Taxonomy of Adverse Drug Reactions as Translational Signals for Drug Repositioning [0.03%]
当副作用成为疗法时：不良药物反应的机制分类及药物再定位的转化信号
Enzo Emanuele,Piercarlo Minoretti,Martina Ballerio et al.
Enzo Emanuele et al.
Background: The systematic conversion of adverse drug reactions (ADRs) into new therapeutic indications represents one of the oldest and most productive sources of repositioned drugs; however, it has not been subjected to...
Association of Acute Kidney Injury and Chronic Kidney Disease With Concentration-To-Dose Ratios of Midazolam and Its Main Metabolites in Critically Ill Adults [0.03%]
急性肾损伤和慢性肾脏疾病与危重成人咪达唑仑及其主要代谢产物浓度-剂量比的关系
Kimberly Shudofsky,Johanna Abma,Johanna Driessen et al.
Kimberly Shudofsky et al.
Background: Midazolam (MDZ) is used for sedation in critically ill patients. Although previous studies have examined MDZ pharmacokinetics in ICU patients, the differential effects of acute kidney injury (AKI) and chronic ...
Observational Study
Fundamental & clinical pharmacology. 2026 Jul;40(4):e70108. DOI:10.1111/fcp.70108 2026
The Effect of Chronic Angiotensin (1-7) Treatment on Functional Responses of Isolated Resistance Arteries in Streptozotocin-Induced Diabetic Rats [0.03%]
慢性Angiotensin(1-7)治疗对链脲佐菌素诱导的糖尿病大鼠离体阻力动脉功能反应的影响
Esra Akcabag,Ikbal Ozen Kucukcetin,Gul Ozbey et al.
Esra Akcabag et al.
Cardiovascular complications of diabetes mellitus (DM) are responsible for morbidity and mortality in DM patients. Recent evidence highlights the pathophysiological role of the renin-angiotensin-aldosterone system in DM. This study determin...
Luc Zimmer,Pascal Bousquet
Luc Zimmer
The current and former editors-in-chief of the Fundamental & Clinical Pharmacology journal share their experience and perspectives regarding the present landscape of scientific publishing and the challenges and threats it faces. Several cha...
Glucagon-Like Peptide-1 Receptor Agonists in Cocaine Use Disorder: Clinical Observations and Underlying Mechanisms [0.03%]
人胰高血糖素样肽-1受体激动剂治疗可卡因使用障碍的临床观察和潜在机制探究
Céline Eiden,Ghjulia Chautard,Anne Batisse et al.
Céline Eiden et al.
Background: Cocaine use disorder (CUD) remains a major public health concern, characterized by high relapse rates and the absence of approved pharmacological treatments. Glucagon-like peptide-1 receptor agonists (GLP-1RA)...
TAAR1-Associated Trace Amines for Cutaneous Nociceptive Blockade in Rats [0.03%]
与TAAR1相关的微量胺可阻断大鼠的皮肤痛觉神经反应
Chong-Chi Chiu,Li-Kai Wang,Yu-Wen Chen et al.
Chong-Chi Chiu et al.
This study aimed to evaluate whether TAAR1 (trace amine-associated receptor 1)-associated trace amines (β-phenylethylamine, tryptamine, octopamine, tyramine, and N-methyltyramine) produced cutaneous nociceptive blockade compared to lidocai...
Comparative Study
Fundamental & clinical pharmacology. 2026 Jul;40(4):e70094. DOI:10.1111/fcp.70094 2026
Synergistic Cardioprotection of Colchicine and Hyperbaric Oxygen Therapy in a Rat Model of Remote Ischemia-Reperfusion Injury [0.03%]
秋水仙碱和高压氧疗法在大鼠远程缺血再灌注损伤模型中的协同心保护作用
Şahhan Kılıç,Süha Asal,Mert Babaoğlu et al.
Şahhan Kılıç et al.
Purpose: Lower extremity ischemia-reperfusion injury (IRI) triggers systemic inflammation and oxidative stress, causing myocardial remote ischemia-reperfusion injury (MIRI). Current treatments are limited. ...
Probucol Exerts Anticancer Effects on SW480 Human Colorectal Cancer Cells via Modulation of Apoptosis- and Angiogenesis-Related Proteins [0.03%]
probucol通过调节与凋亡和血管生成相关的蛋白质对SW480人类结直肠癌细胞的抗癌作用
Ecem Kaya-Sezginer,Filiz Bakar-Ates
Ecem Kaya-Sezginer
Colorectal cancer remains one of the leading causes of cancer-related mortality worldwide, highlighting the need for novel therapeutic agents with multitarget anticancer activity. Probucol is a phenolic compound with well-established antiox...
Nebivolol Protects the Thoracic and Abdominal Aorta and Their Perivascular Adipose Tissue From the Differential Detrimental Effects of Obesity [0.03%]
奈必洛尔保护肥胖大鼠的胸主动脉和腹主动脉及其血管周围脂肪组织
Thales M H Dourado,Gustavo F Pimenta,Leonardo P Silva et al.
Thales M H Dourado et al.
The effects of obesity on the vasculature and perivascular adipose tissue (PVAT) function vary according to the vascular territory. Nebivolol is a third-generation β-blocker that exerts vasculoprotective effects in obesity. The thoracic an...