VEGF signaling mediates bladder neuroplasticity and inflammation in response to BCG [0.03%]
VEGF信号通路介导BCG膀胱神经可塑性及炎症反应
Marcia R Saban,Carole A Davis,Antonio Avelino et al.
Marcia R Saban et al.
Background: This work tests the hypothesis that increased levels of vascular endothelial growth factor (VEGF) observed during bladder inflammation modulates nerve plasticity. ...
Gayathri Krishnamoorthy,Keil Regehr,Samantha Berge et al.
Gayathri Krishnamoorthy et al.
Background: Calcium sparks are ryanodine receptor mediated transient calcium signals that have been shown to hyperpolarize the membrane potential by activating large conductance calcium activated potassium (BK) channels i...
Morten R Clausen,Kirstine L Christensen,Mette S Hedemann et al.
Morten R Clausen et al.
Background: Pigs are widely used as models for human physiological changes in intervention studies, because of the close resemblance between human and porcine physiology and the high degree of experimental control when us...
Monitoring the wild black bear's reaction to human and environmental stressors [0.03%]
监测人类和环境压力因素对野生黑熊的影响
Timothy G Laske,David L Garshelis,Paul A Iaizzo
Timothy G Laske
Background: Bears are among the most physiologically remarkable mammals. They spend half their life in an active state and the other half in a state of dormancy without food or water, and without urinating, defecating, or...
Elda L Pacheco-Pantoja,Lakshminarayan R Ranganath,James A Gallagher et al.
Elda L Pacheco-Pantoja et al.
Background: In recent years the interest on the relationship of gut hormones to bone processes has increased and represents one of the most interesting aspects in skeletal research. The proportion of bone mass to soft tis...
Regulation of Caenorhabditis elegans vitellogenesis by DAF-2/IIS through separable transcriptional and posttranscriptional mechanisms [0.03%]
DAF-2/IIS通过可分离的转录和转录后机制调节秀丽隐杆线虫的卵黄基因合成
Ana S DePina,Wendy B Iser,Sung-Soo Park et al.
Ana S DePina et al.
Background: Evolutionary theories of aging propose that longevity evolves as a competition between reproduction and somatic maintenance for a finite pool of resources. Reproduction is thought to shorten lifespan by deplet...
The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes [0.03%]
外源性亮氨酸对人肌管mTOR信号传导和氨基酸转运蛋白的作用
Petra Gran,David Cameron-Smith
Petra Gran
Background: The branched-chain amino acid (BCAA) leucine has been identified to be a key regulator of skeletal muscle anabolism. Activation of anabolic signalling occurs via the mammalian target of rapamycin (mTOR) throug...
Regional expression of HOXA4 along the aorta and its potential role in human abdominal aortic aneurysms [0.03%]
HOXA4在主动脉上的区域表达及其在人类腹主动脉瘤中的潜在作用
John H Lillvis,Robert Erdman,Charles M Schworer et al.
John H Lillvis et al.
Background: The infrarenal abdominal aorta exhibits increased disease susceptibility relative to other aortic regions. Allograft studies exchanging thoracic and abdominal segments showed that regional susceptibility is ma...
Comparative Study
BMC physiology. 2011 May 31:11:9. DOI:10.1186/1472-6793-11-9 2011
Non-endothelial endothelin counteracts hypoxic vasodilation in porcine large coronary arteries [0.03%]
非内皮性内皮素对抗猪大冠状动脉缺血所致血管舒张作用
Elise R Hedegaard,Edgaras Stankevicius,Ulf Simonsen et al.
Elise R Hedegaard et al.
Background: The systemic vascular response to hypoxia is vasodilation. However, reports suggest that the potent vasoconstrictor endothelin-1 (ET-1) is released from the vasculature during hypoxia. ET-1 is reported to augm...
Expression of human amyloid precursor protein in the skeletal muscles of Drosophila results in age- and activity-dependent muscle weakness [0.03%]
人源淀粉样前体蛋白在果蝇骨骼肌中的表达导致年龄和活动依赖性肌肉无力
Chul Kim,Sapeckshita Srivastava,Marian Rice et al.
Chul Kim et al.
Background: One of the hallmarks of Alzheimer's disease, and several other degenerative disorders such as Inclusion Body Myositis, is the abnormal accumulation of amyloid precursor protein (APP) and its proteolytic amyloi...