Exercise endurance capacity is markedly reduced due to impaired energy homeostasis during prolonged fasting in FABP4/5 deficient mice [0.03%]
由于长时间禁食时能量稳态受损，FABP4/5缺陷小鼠的运动耐力显著下降
Tatsuya Iso,Hikari Haruyama,Hiroaki Sunaga et al.
Tatsuya Iso et al.
Background: Skeletal muscle prefers carbohydrate use to fatty acid (FA) use as exercise intensity increases. In contrast, skeletal muscle minimizes glucose use and relies more on FA during fasting. In mice deficient for F...
Deficiency of the BMP Type I receptor ALK3 partly protects mice from anemia of inflammation [0.03%]
BMP类型I受体ALK3部分缺陷使小鼠免于炎症性贫血
Inka Gallitz,Niklas Lofruthe,Lisa Traeger et al.
Inka Gallitz et al.
Background: Inflammatory stimuli induce the hepatic iron regulatory hormone hepcidin, which contributes to anaemia of inflammation (AI). Hepcidin expression is regulated by the bone morphogenetic protein (BMP) and the int...
Regulation of Locomotor activity in fed, fasted, and food-restricted mice lacking tissue-type plasminogen activator [0.03%]
组织型纤溶酶原激活剂缺失小鼠在喂养、饥饿和限食状态下的运动活动调节机制研究
Jessica A Krizo,Linley E Moreland,Ashutosh Rastogi et al.
Jessica A Krizo et al.
Background: Circadian rhythms of physiology and behavior are driven by a circadian clock located in the suprachiasmatic nucleus of the hypothalamus. This clock is synchronized to environmental day/night cycles by photic i...
Claudin expression during early postnatal development of the murine cochlea [0.03%]
小鼠耳蜗发育早期紧密连接蛋白Claudin的表达模式研究
Takayuki Kudo,Philine Wangemann,Daniel C Marcus
Takayuki Kudo
Background: Claudins are major components of tight junctions, which form the paracellular barrier between the cochlear luminal and abluminal fluid compartments that supports the large transepithelial voltage difference an...
Adiponectin is required for maintaining normal body temperature in a cold environment [0.03%]
adiponectin在寒冷环境中维持正常体温的必要性
Qiong Wei,Jong Han Lee,Hongying Wang et al.
Qiong Wei et al.
Background: Thermogenic impairment promotes obesity and insulin resistance. Adiponectin is an important regulator of energy homeostasis. While many beneficial metabolic effects of adiponectin resemble that of activated th...
Androgen receptor is expressed in mouse cardiomyocytes at prenatal and early postnatal developmental stages [0.03%]
雄激素受体表达于小鼠心脏发育的胎儿及早期出生阶段
Enrique Pedernera,María José Gómora,Iván Meneses et al.
Enrique Pedernera et al.
Background: Previous studies show that androgens are involved in hypertrophy and excitability of cardiomyocytes and that their effects are mediated through their receptor. The aim of this study was to evaluate the presenc...
Disulfide high mobility group box-1 causes bladder pain through bladder Toll-like receptor 4 [0.03%]
二硫键处理的高迁移率族蛋白箱1通过 toll 样受体4 引起膀胱痛
Fei Ma,Dimitrios E Kouzoukas,Katherine L Meyer-Siegler et al.
Fei Ma et al.
Background: Bladder pain is a prominent symptom in several urological conditions (e.g. infection, painful bladder syndrome/interstitial cystitis, cancer). Understanding the mechanism of bladder pain is important, particul...
Endothelial dysfunction in the pathogenesis of pre-eclampsia in Ghanaian women [0.03%]
吉布尼亚妇女妊娠高血压综合征的病理发生中的内皮功能障碍
Kwame Adu-Bonsaffoh,Daniel Ansong Antwi,Ben Gyan et al.
Kwame Adu-Bonsaffoh et al.
Background: Pre-eclampsia (PE) remains a disease of theories despite extensive research into its etiology. Alteration in the production of vascular endothelial growth factor (VEGF), a biomarker of endothelial dysfunction,...
Short-term overfeeding of zebrafish with normal or high-fat diet as a model for the development of metabolically healthy versus unhealthy obesity [0.03%]
用正常或高脂肪饮食短期过度喂养斑马鱼作为代谢健康与不健康肥胖发展的模型
Kathrin Landgraf,Susanne Schuster,Andrej Meusel et al.
Kathrin Landgraf et al.
Background: Obese individuals differ in their risk of developing metabolic and cardiovascular complications depending on fat distribution (subcutaneous versus visceral) and adipose tissue (AT) phenotype (hyperplasic versu...
Myocardial susceptibility to ischaemia/reperfusion in obesity: a re-evaluation of the effects of age [0.03%]
肥胖对心肌缺血/再灌注的易感性：年龄影响的再评价
I Webster,R Salie,E Marais et al.
I Webster et al.
Background: Reports on the effect of age and obesity on myocardial ischaemia/reperfusion (I/R) injury and ischaemic preconditioning are contradictory. The aim of this study was to re-evaluate the effects of age and diet-i...