Inference of mechanical states of intestinal motor activity using hidden Markov models [0.03%]
基于隐马尔可夫模型的肠道运动状态的推断
Lukasz Wiklendt,Marcello Costa,Phil G Dinning
Lukasz Wiklendt
Background: Contractions and relaxations of the muscle layers within the digestive tract alter the external diameter and the internal pressures. These changes in diameter and pressure move digesting food and waste product...
The endotoxin/toll-like receptor-4 axis mediates gut microvascular dysfunction associated with post-prandial lipidemia [0.03%]
内毒素/ toll样受体-4轴介导餐后脂血症相关肠微血管功能障碍
Ping Yi,Jia Pang,Jonathan Steven Alexander et al.
Ping Yi et al.
Background: Postprandial lipidemia is important in the development of coronary artery disease (CAD). Consumption of a meal high in monounsaturated fat was correlated with acute impairment of endothelial function. However,...
Alexander G Tonevitsky,Diana V Maltseva,Asghar Abbasi et al.
Alexander G Tonevitsky et al.
Background: MiRNAs are essential mediators of many biological processes. The aim of this study was to investigate the dynamics of miRNA-mRNA regulatory networks during exercise and the subsequent recovery period. ...
Overtraining is associated with DNA damage in blood and skeletal muscle cells of Swiss mice [0.03%]
过度训练与瑞士小鼠血液和骨骼肌细胞DNA损伤有关
Bruno Cesar Pereira,José Rodrigo Pauli,Lusânia Maria Greggi Antunes et al.
Bruno Cesar Pereira et al.
Background: The alkaline version of the single-cell gel (comet) assay is a useful method for quantifying DNA damage. Although some studies on chronic and acute effects of exercise on DNA damage measured by the comet assay...
Estrogen-related receptor β deficiency alters body composition and response to restraint stress [0.03%]
雌激素受体β缺乏改变身体构成和对拘禁压力的反应
Mardi S Byerly,Roy D Swanson,G William Wong et al.
Mardi S Byerly et al.
Background: Estrogen-related receptors (ERRs) are orphan nuclear hormone receptors expressed in metabolically active tissues and modulate numerous homeostatic processes. ERRs do not bind the ligand estrogen, but they are ...
Significance of K(ATP) channels, L-type Ca²⁺ channels and CYP450-4A enzymes in oxygen sensing in mouse cremaster muscle arterioles in vivo [0.03%]
KATP通道、L型Ca²⁺通道和CYP450-4A酶在小鼠四肢肌包膜动脉中氧感受中的意义
Anh Thuc Ngo,Mads Riemann,Niels-Henrik Holstein-Rathlou et al.
Anh Thuc Ngo et al.
Background: ATP-sensitive K⁺ channels (KATP channels), NO, prostaglandins, 20-HETE and L-type Ca²⁺ channels have all been suggested to be involved in oxygen sensing in skeletal muscle arterioles, but the role of the in...
Liver-derived endocrine IGF-I is not critical for activation of skeletal muscle protein synthesis following oral feeding [0.03%]
口服喂养后激活骨骼肌蛋白质合成无需肝源内分泌IGF-I参与
Britt-Marie Iresjö,Johan Svensson,Claes Ohlsson et al.
Britt-Marie Iresjö et al.
Background: Insulin-like growth factor-1 (IGF-1) is produced in various tissues to stimulate protein synthesis under different conditions. It is however, difficult to distinguish effects by locally produced IGF-1 compared...
cAMP-stimulated Cl- secretion is increased by glucocorticoids and inhibited by bumetanide in semicircular canal duct epithelium [0.03%]
糖皮质激素诱导的半规管壶腹壶腹部上皮环路的功能效应及丁苯蝶啶的抑制作用
Satyanarayana R Pondugula,Suresh B Kampalli,Tao Wu et al.
Satyanarayana R Pondugula et al.
Background: The vestibular system controls the ion composition of its luminal fluid through several epithelial cell transport mechanisms under hormonal regulation. The semicircular canal duct (SCCD) epithelium has been sh...
Quinine controls body weight gain without affecting food intake in male C57BL6 mice [0.03%]
金鸡纳霜可通过控制小鼠体重而不影响其食物摄入量来发挥减肥功效
Philippe Cettour-Rose,Carole Bezençon,Christian Darimont et al.
Philippe Cettour-Rose et al.
Background: Quinine is a natural molecule commonly used as a flavouring agent in tonic water. Diet supplementation with quinine leads to decreased body weight and food intake in rats. Quinine is an in vitro inhibitor of T...
Importance of uncharged polar residues and proline in the proximal two-thirds (Pro107-Ser128) of the highly conserved region of mouse ileal Na+-dependent bile acid transporter, Slc10a2, in transport activity and cellular expression [0.03%]
鼠回肠Na+依赖性胆汁酸转运蛋白Slc10a2高度保守区域近端三分之二（Pro107-Ser128）无电荷极性残基和脯氨酸对转运活性及细胞表达的作用
Tohru Saeki,Kosuke Sato,Shiho Ito et al.
Tohru Saeki et al.
Background: SLC10A2-mediated reabsorption of bile acids at the distal end of the ileum is the first step in enterohepatic circulation. Because bile acids act not only as detergents but also as signaling molecules in lipid...