Increased expression and local accumulation of the prion protein, Alzheimer Aβ peptides, superoxide dismutase 1, and nitric oxide synthases 1 & 2 in muscle in a rabbit model of diabetes [0.03%]
糖尿病兔模型肌肉中prion蛋白、Alzheimer Aβ肽、超氧化物歧化酶1及一氧化氮合酶1和2表达增强及聚集增多
Claudine L Bitel,Yicheng Feng,Nizar Souayah et al.
Claudine L Bitel et al.
Background: Muscle disease associated with different etiologies has been shown to produce localized accumulations of amyloid and oxidative stress-related proteins that are more commonly associated with neurodegeneration i...
Computational simulation of vasopressin secretion using a rat model of the water and electrolyte homeostasis [0.03%]
大鼠水和电解质平衡模型的血管加压素分泌计算模拟研究
Louis Nadeau,Danielle Arbour,Didier Mouginot
Louis Nadeau
Background: In mammals, vasopressin (AVP) is released from magnocellular neurons of the hypothalamus when osmotic pressure exceeds a fixed set-point. AVP participates to the hydromineral homeostasis (HH) by controlling wa...
Development of electrocardiogram intervals during growth of FVB/N neonate mice [0.03%]
FVB/N近交系小鼠生长过程中心电图间隔的变化规律研究
Christopher R Heier,Thomas G Hampton,Deli Wang et al.
Christopher R Heier et al.
Background: Electrocardiography remains the best diagnostic tool and therapeutic biomarker for a spectrum of pediatric diseases involving cardiac or autonomic nervous system defects. As genetic links to these disorders ar...
Anupama Barua,Nicholas B Standen,Manuel Galiñanes
Anupama Barua
Background: Nitric oxide (NO) is cardioprotective and a mediator of ischemic preconditioning (IP). Endothelial nitric oxide synthase (eNOS) is protective against myocardial ischemic injury and a component of IP but the ro...
Peristalsis in the junction region of the Drosophila larval midgut is modulated by DH31 expressing enteroendocrine cells [0.03%]
DH31表达的肠内分泌细胞调节果蝇幼虫中肠连接区域的蠕动运动
Dennis R LaJeunesse,Brooke Johnson,Jason S Presnell et al.
Dennis R LaJeunesse et al.
Background: The underlying cellular and molecular mechanisms that coordinate the physiological processes in digestion are complex, cryptic, and involve the integration of multiple cellular and organ systems. In all intest...
Morphological and molecular characterization of developing vertebral fusions using a teleost model [0.03%]
利用硬骨鱼模型对发育中椎体融合的形态和分子特征进行表征
Elisabeth Ytteborg,Jacob Torgersen,Grete Baeverfjord et al.
Elisabeth Ytteborg et al.
Background: Spinal disorders are a major cause of disability for humans and an important health problem for intensively farmed animals. Experiments have shown that vertebral deformities present a complex but comparable et...
Molecular pathology of vertebral deformities in hyperthermic Atlantic salmon (Salmo salar) [0.03%]
高温环境下大西洋鲑鱼脊柱畸形的分子病理学研究
Elisabeth Ytteborg,Grete Baeverfjord,Jacob Torgersen et al.
Elisabeth Ytteborg et al.
Background: Hyperthermia has been shown in a number of organisms to induce developmental defects as a result of changes in cell proliferation, differentiation and gene expression. In spite of this, salmon aquaculture comm...
Resveratrol suppresses body mass gain in a seasonal non-human primate model of obesity [0.03%]
白藜芦醇通过非人灵长类季节性肥胖模型的体重增加抑制作用发挥减肥功效
Alexandre Dal-Pan,Stéphane Blanc,Fabienne Aujard
Alexandre Dal-Pan
Background: Resveratrol, a natural polyphenolic compound, was shown to protect rodents against high-fat-diet induced diabesity by boosting energy metabolism. To the best of our knowledge, no data is yet available on the e...
Sinoatrial tissue of crucian carp heart has only negative contractile responses to autonomic agonists [0.03%]
crucian carp心脏窦房组织自主神经激动剂呈单一的负性收缩反应
Matti Vornanen,Mervi Hälinen,Jaakko Haverinen
Matti Vornanen
Background: In the anoxia-tolerant crucian carp (Carassius carassius) cardiac activity varies according to the seasons. To clarify the role of autonomic nervous control in modulation of cardiac activity, responses of atri...
Sterol carrier protein-x gene and effects of sterol carrier protein-2 inhibitors on lipid uptake in Manduca sexta [0.03%]
胆固醇载体蛋白-x基因及胆固醇载体蛋白-2抑制剂对 Manduca sexta 的脂质摄取的影响
Min-Sik Kim,Que Lan
Min-Sik Kim
Background: Cholesterol uptake and transportation during the feeding larval stages are critical processes in insects because they are auxotrophic for exogenous (dietary) cholesterol. The midgut is the main site for choles...