Daniel C Javitt
Daniel C Javitt
N-methyl-D-aspartate (NMDA) receptor dysfunction may play a key role in the pathophysiology of schizophrenia. Recent studies have investigated the ability of NMDA/glycine-site modulators to ameliorate persistent negative and cognitive sympt...
Positive modulators of AMPA receptors as a potential treatment for schizophrenia [0.03%]
作为治疗精神分裂症潜在手段的AMPA受体阳性别构调节剂
Wojciech Danysz
Wojciech Danysz
There is a consensus that current treatments of schizophrenia do not offer satisfactory efficacy for negative and cognitive symptoms. Recently, the dopaminergic hyperfunction hypothesis of schizophrenia has been enriched by the addition of ...
Martin Hulpke-Wette,Reiner Buchhorn
Martin Hulpke-Wette
Bristol-Myers Squibb is developing BMS-193884, an oral endothelin antagonist, for the potential treatment of congestive heart failure (CHF) and pulmonary hypertension [206604]. The compound entered phase I trials in November 1996 [242721] a...
S-0139 (Shionogi) [0.03%]
诗华诺吉-S-0139
J Ruth Wu-Wong
J Ruth Wu-Wong
Shionogi and GlaxoSmithKline (GSK), as the joint venture company Shionogi-GlaxoSmithKline Pharmaceuticals LLC, are developing S-0139 (SB-737004), an endothelin-A (ETA) antagonist, for the potential treatment of hemorrhagic and ischemic stro...
Sudden cardiac death: from molecular biology and cellular electrophysiology to therapy [0.03%]
从分子生物学和细胞电生理学到治疗的突发性心脏死亡研究
Ivan Kocić
Ivan Kocić
Sudden cardiac death (SCD) is one of the most serious problems of clinical cardiology and public health, because of its unexpected and sudden occurrence and poor response to resuscitation. Until recently, the many cases of SCD, apart from t...
Johann Auer,Robert Berent,Bernd Eber
Johann Auer
There is good evidence that amiodarone is effective against a variety of arrhythmias and that it may be superior to other drugs in some settings. Because of its proven efficacy and safety, amiodarone is currently the leading antiarrhythmic ...
Johann Auer,Robert Berent,Thomas Weber et al.
Johann Auer et al.
Sudden cardiac death is a leading cause of mortality in industrialized nations, accountingfor 50% of all cardiovascular deaths. Carefully performed randomized trials, technological advances and better understanding of arrhythmia mechanisms ...
Judith Soberman,Carol C Chafin,Karl T Weber
Judith Soberman
The role of aldosterone in the pathophysiology of congestive heart failure (CHF) has long been recognized. The recent RALES (Randomized Aldactone Evaluation Study) trial demonstrated early reduction in morbidity and mortality using spironol...
Eculizumab (Alexion) [0.03%]
厄库珠单抗（阿勒克斯尼オン）
Mariana Kaplan
Mariana Kaplan
Eculizumab (5G1.1), a humanized monoclonal antibody that prevents the cleavage of human complement component C5 into its pro-inflammatory components, is under development by Alexion as a potential treatment for several chronic inflammatory ...
Suppression of inflammation and joint destruction in rheumatoid arthritis may require a concerted action of Th2 cytokines [0.03%]
抑制风湿性关节炎的炎症和关节破坏可能需要Th2细胞因子的协同作用
Joel A G van Roon,Johannes W J Bijlsma,Floris P J G Lafeber
Joel A G van Roon
A predominance of T-helper 1 (Th1) activity and a lack of Th2 activity has been documented in the inflamed joints of patients with rheumatoid arthritis (RA). This imbalance is suggested to contribute to activation of, particularly, inflamma...