Yanhong Wang,Huimin Fu,Zhen Zou
Yanhong Wang
Entomopathogenic fungi and bacteria offer promising alternatives to chemical insecticides for controlling mosquitoes and ticks-key vectors of malaria and Lyme disease. However, their efficacy largely depends on immune interactions between p...
Irène Landau,Timothy Little,Érika Martins Braga
Irène Landau
Albert Tell I Puig,Dominique Soldati-Favre
Albert Tell I Puig
Zeng et al. and Qian et al. reveal in their cryogenic electron microscopy (cryo-EM) studies how apicomplexan parasites extensively remodel tubulin to construct the conoid, a specialized invasion organelle. Distinct microtubule assemblies in...
Hidden passengers: expanding the RNA virosphere of trypanosomatids [0.03%]
隐藏的乘客：扩张刺吸式节肢动物单细胞寄生虫类微生物诱导剂病毒圈
Alexei Yu Kostygov,Danyil Grybchuk,Vyacheslav Yurchenko
Alexei Yu Kostygov
The diversity of trypanosomatid RNA viruses goes far beyond the well-known leishmaniaviruses. Newly discovered viral lineages across multiple families reveal host-specific patterns and distant evolutionary transitions, highlighting the traj...
The endemic dilemma: why whole sporozoite malaria vaccine efficacy falls in the field [0.03%]
疟疾原虫地方性传播之谜：为何间日疟孢子体疫苗效力大打折扣
Mariah Hassert,John T Harty
Mariah Hassert
Whole sporozoite vaccines (WSVs) are the most effective malaria vaccines developed to date. However, their durable efficacy declines sharply when moving from homologous CHMI studies to field trials in endemic regions. We argue this reduced ...
Angomonas deanei [0.03%]
德阿内暗.MONAS属细菌
Natascha A van Geelen-Kuenzel,Vyacheslav Yurchenko,Julius Lukeš et al.
Natascha A van Geelen-Kuenzel et al.
Dongjing Zhang,Li Ming,Jérémy Bouyer
Dongjing Zhang
Goldman et al. and Houri-Zeevi et al. reveal how Aedes mosquitoes mate and the molecular bases of these interactions. Invasive Aedes mosquitoes are the vectors of arboviruses, causing an ever-increasing health burden. New sexual attributes ...
Qilong Li,Qijun Chen
Qilong Li
Pazicky et al. introduced a thermal profiling method, meltome-assisted profiling of protein complexes (MAP-X), combined with machine learning, to map protein complex dynamics in intact Plasmodium falciparum, a deadly malaria parasite. This ...
Zhili Shan,Qun Liu,Yong Fu
Zhili Shan
Recent studies by Romano et al. and Mehra et al. reveal that Toxoplasma gondii actively connects its parasitophorous vacuole to the host endoplasmic reticulum. Through a parasitic secretory relay involving dense granule and rhoptry effector...
Badreddine Elmakhzen,Nada El Makhzen,Hugues Abriel
Badreddine Elmakhzen