The Drug Design & Development Seminar 2026: joining forces with the European Cost Action 'OneHealthDrugs' [0.03%]
药物设计与开发研讨会2026：与欧洲科斯行动“onehealthdrugs”联合力量
Simone Haeberlein,Christoph G Grevelding,Franco H Falcone et al.
Simone Haeberlein et al.
Post-transcriptional RNA-mediated regulation in infection: mechanisms, functions, and analytical approaches [0.03%]
感染后的转录后RNA介导的调控：机制、功能和分析方法
Mame Massar Dieng,Jean-Claude Twizere,Youssef Idaghdour
Mame Massar Dieng
Infectious pathogens extensively rewire host RNA processing, yet most studies examine individual processing mechanisms in isolation. In this review, we synthesize evidence that alternative splicing, N6-methyladenosine (m6A) methylation, and...
Julie Bas,Philippe Jay
Julie Bas
Parasites elicit a wide range of gastrointestinal symptoms, often attributed to tissue damage or alterations in the gut microbiota. A recent study by Touhara et al. pioneers the functional understanding of a collaboration between chemosenso...
Reassessing malaria-transmitting mosquito evolution with a neotropical lens [0.03%]
用新热带视角重新评估疟疾传播蚊子的进化历程
Tamar E Carter,Isuru Gunarathna
Tamar E Carter
Tennessen et al.'s study addresses longstanding knowledge gaps regarding the evolutionary drivers of a major Neotropical malaria vector, Anopheles darlingi. Through extensive whole-genome analysis, they revealed geographically structured An...
Markus Engstler
Markus Engstler
A new study by Lansink et al. identifies an expression-site-body-associated RNA nuclease that selectively attenuates expression-site-associated gene transcripts, showing that antigenic variation in Trypanosoma brucei is refined not only by ...
Jiaqi Wang,Zeming Wu,Xuemin Jin
Jiaqi Wang
The persistence of tissue-dwelling parasites represents a profound challenge in infectious disease management, traditionally attributed to intrinsic biochemical resistance against anthelmintic agents. However, cross-disciplinary evidence su...
From biosynthesis to scavenging: evolutionary rewiring of PUFA and oxylipin biosynthesis in parasitic nematodes [0.03%]
从生物合成到清除：寄生线虫中PUFA和oxylipin生物合成的进化重构
Dongjuan Yuan,Hongyi Li,Muchun Wan et al.
Dongjuan Yuan et al.
Polyunsaturated fatty acids (PUFAs) and their oxygenated metabolites (oxylipins) are mediators in regulating membrane function, larval development, and host immune response. In this review, we present that free-living nematodes maintain a r...
Silu Deng,Junjie Liu,Mingfei Sun et al.
Silu Deng et al.
Increasing evidence suggests that regulatory noncoding RNAs (ncRNAs) modulate a series of epithelial responses following Cryptosporidium invasion. During infection, ncRNAs are involved in the activation of intracellular signaling pathways, ...
Time to rethink Blastocystis in faecal microbiota transplantation [0.03%]
粪便微生物移植中重新评估 Blastocystis 的时机
Anders Krifors,Torbjörn Larsson,Andreas Wångdahl et al.
Anders Krifors et al.
Blastocystis commonly colonises the human gut, but its presence has traditionally led to the exclusion of faecal microbiota transplantation donors. Emerging evidence links it to greater microbial diversity and favourable metabolic profiles,...
Coevolution stabilizes the honey bee-Varroa destructor-virus system on islands [0.03%]
共进化稳定了岛屿上的蜜蜂- Varroa destructor-病毒系统
Laura E Brettell,Clarissa P Ferreira,Ethel M Villalobos et al.
Laura E Brettell et al.
For 65 years, the ectoparasitic mite Varroa destructor, along with the deformed wing virus (DWV) it vectors, has killed millions of Apis mellifera honey bee colonies globally. The coevolution of the 'bee-mite-virus' system in Hawaii over 17...