Amin Azimi,Reza Salavati
Amin Azimi
Independent protein-protein interaction networks in kinetoplastid parasites show little overlap, often interpreted as biological divergence. We argue that this pattern largely reflects fragmented sampling. Integrating interactomes from Tryp...
Henry J McSorley,Danielle J Smyth,Gregor Fisher
Henry J McSorley
No vaccines are currently available for any gastrointestinal nematode (GIN) infections of humans, despite a large global burden of disease. In livestock, limited helminth vaccines are available, while current anthelmintic treatments are wan...
Controlled human helminth infection models: insights into type 2 immunity and therapeutic development [0.03%]
可控的人类蠕虫感染模型：2型免疫和治疗开发的见解
H Richard Droghini,Thomas B Nutman,P&#x;ng Loke
H Richard Droghini
Controlled human infection models are powerful tools for evaluating pathogenesis, immune responses, vaccines, and therapeutics, including parasitic helminths. Helminths have also been tested as inflammatory disease therapeutics. This review...
Colorful parasites: an overlooked frontier in animal coloration research [0.03%]
色彩斑斓的寄生虫——动物色泽研究中被忽视的一块阵地
Ryota Hasegawa,Robert Poulin
Ryota Hasegawa
The diverse coloration of animals has fascinated researchers over the past centuries. A growing body of evidence has documented the many functions of animal coloration, ranging from mate attraction to predator avoidance. Yet, the adaptive f...
Wim Adriaensen,Nicky de Vrij,Thao-Thy Pham et al.
Wim Adriaensen et al.
Despite the global burden of leishmaniasis, no licensed human vaccine exists. Vaccine antigens are typically based on in silico predictions or their immunogenicity in animal models and cured patients. T cell epitopes have only been mapped f...
With a little help from my friend: engaging CD44 facilitates Plasmodium falciparum invasion of erythrocytes [0.03%]
同朋友合作：CD44的参与促进恶性疟原虫侵入红细胞
Laurent Rénia
Laurent Rénia
Merozoite invasion in erythrocytes is a complex process. Kongsomboonvech et al. identify the host transmembrane protein CD44 as a critical coreceptor that, when crosslinked, significantly enhances the ability of Plasmodium falciparum to inv...
Engaging minds, building competence: case-based e-learning in parasitology [0.03%]
寓教于乐，教学相长：基于案例的寄生虫学在线学习
Beata Kirk,Ghazanfar Abbas,Tanapan Sukee et al.
Beata Kirk et al.
The COVID-19 pandemic reshaped parasitology education, exposing challenges in delivering laboratory-rich, experiential learning. Case-based e-learning (CBEL) emerged as a powerful solution, restoring engagement through authentic, adaptive, ...
A protein-based self-assembled nanoparticle provides an improved malarial vaccine [0.03%]
一种蛋白质自我组装的纳米颗粒型改良疟疾疫苗
Matthew R Groves,Siyao Chen
Matthew R Groves
Shi et al. recently published a report leveraging the self-assembly of the Pdx1 and Pdx2 proteins as a vaccine platform. This elegant approach achieved complete sterile protection in mouse models, providing a promising avenue to accomplish ...
Evi Hadjimichael,Kirk W Deitsch
Evi Hadjimichael
Malaria parasites display the unique property of expressing distinct ribosomal RNAs at different points in their transmission cycle. Couble et al. determined that derepression of the mosquito-specific rDNA loci is initiated by altered NAD+/...
Etienne G J Danchin
Etienne G J Danchin
Root-knot nematodes are among the most destructive plant parasites on Earth. Many aspects of their biology are fascinating, including their diverse reproductive modes, their extreme polyphagy, their unknown origin, and their sophisticated p...