Babesia microti [0.03%]
微小巴贝虫
Sen Wang,Junlong Zhao,Lan He
Sen Wang
Theileria orientalis [0.03%]
东普氏泰勒虫
Abdul Ghafar,Ard M Nijhof,Abdul Jabbar
Abdul Ghafar
Yicheng Zhao,Jun Zheng,Quan Liu
Yicheng Zhao
Zhang et al. provide the first global synthesis of 230 emerging tick-borne viruses, introducing a genomic model that predicts zoonotic risk. Their approach identifies 25 very-high-risk viruses and clinically validates three novel human path...
Polypharmacology in malaria treatment: single drugs, multiple mechanisms, greater impact [0.03%]
恶性疟的多药理学研究：单一药物、多种机制和更大疗效
Mira Milić,Prisca Obi,Christopher D Vanderwal et al.
Mira Milić et al.
Malaria remains a global health crisis, exacerbated by the rise of drug-resistant strains of Plasmodium species to clinically used drugs, as well as newly developed therapeutic agents. Historically, natural-product-derived drugs such as qui...
Host manipulation by Drosophila parasitoid wasps: molecular tools and strategic insights [0.03%]
寄生于果蝇的寄生黄蜂：分子工具与策略见解
Jiani Chen,Zeying Wang,Zixuan Xu et al.
Jiani Chen et al.
Parasitoid wasps are a remarkably diverse group of insects that employ intricate parasitic strategies. Their reproductive success largely depends on their ability to precisely manipulate their hosts. The Drosophila-parasitoid wasp system is...
Fangyan Liu,Xianzhi Meng,Guoqing Pan et al.
Fangyan Liu et al.
Microsporidia are obligate intracellular parasites that can infect various invertebrate and vertebrate species, including humans. They have evolved resistance strategies to survive in their ecological niche. When dormant, microsporidia exis...
Pedro P D Lucinda,Matthew C Sinton,Juan F Quintana et al.
Pedro P D Lucinda et al.
In this review, we tell the story of how two related parasites that belong to the same genus, Trypanosoma brucei and Trypanosoma cruzi, cause very distinct lethal diseases and how γδ T cells help shape these outcomes. It synthesizes curre...
Bret M Boyd,Sarah E Bush,Colin Dale
Bret M Boyd
Insects have formed close relationships with endosymbiotic microorganisms, enabling adaptation and promoting diversification. In this review, we examined studies of endosymbiotic bacteria in parasitic lice (Psocodea: Phthiraptera). Lice and...
Tumor-suppressor pathways in Schistosoma mansoni support a novel hypothesis on neodermatan flatworm origins [0.03%]
曼氏血吸虫抑癌通路支持后螠门起源新假说
Paul J Brindley
Paul J Brindley
Wendt and Collins identify a cyclin-dependent kinase inhibitor (cki) in Schistosoma mansoni that, along with p53-1 (schistosome homolog of TP-53), suppresses tegument cell proliferation. Knockdown of cki causes hyperproliferation and, toget...
Andrew A Davinack
Andrew A Davinack
Polymerase chain reaction (PCR) plays a central role in parasite diagnostics but is increasingly interpreted as a general test for parasitic infection. Because parasites lack shared molecular features amenable to universal assays, PCR is in...