Echinococcus multilocularis [0.03%]
多房棘球绦虫
Adriano Casulli,Thomas F E Barth,Francesca Tamarozzi
Adriano Casulli
Malaria Vectors and Species Complexes in Thailand: Implications for Vector Control [0.03%]
泰国疟疾病媒及其物种复式对病媒控制的含义
Chatchai Tananchai,Sylvie Manguin,Michael J Bangs et al.
Chatchai Tananchai et al.
There are seven Anopheles species incriminated as important (primary) malaria vectors in Thailand. These vectors belong to species complexes or are in closely related groups that are difficult to separate morphologically. Precise species id...
Ozonide Antimalarial Activity in the Context of Artemisinin-Resistant Malaria [0.03%]
臭氧化物的抗疟活性及其在青蒿素耐药性疟疾背景下的作用
Carlo Giannangelo,Freya J I Fowkes,Julie A Simpson et al.
Carlo Giannangelo et al.
The ozonides are one of the most advanced drug classes in the antimalarial development pipeline and were designed to improve on limitations associated with current front-line artemisinin-based therapies. Like the artemisinins, the pharmacop...
Next-Generation Phenotypic Screening in Early Drug Discovery for Infectious Diseases [0.03%]
传染病药物早期发现中的下一代表型筛选技术
Nathalie Aulner,Anne Danckaert,JongEun Ihm et al.
Nathalie Aulner et al.
Cell-based phenotypic screening has proven to be valuable, notably in recapitulating relevant biological conditions, for example, the host cell/pathogen niche. However, the corresponding methodological complexity is not readily compatible w...
Plasmodium vivax [0.03%]
间日疟原虫
Erika L Flannery,Miles B Markus,Ashley M Vaughan
Erika L Flannery
Transmission-Blocking Vaccines for Malaria: Time to Talk about Vaccine Introduction [0.03%]
疟疾传播阻断疫苗：是时候讨论疫苗的引入了
Camila H Coelho,Rino Rappuoli,Peter J Hotez et al.
Camila H Coelho et al.
Malaria kills more than 600 000 people yearly, mainly children, and eradication is a global priority. Malaria transmission-blocking vaccines are advancing in clinical trials, and strategies for their introduction must be prioritized among s...
Kateřina Sobotková,William Parker,Jana Levá et al.
Kateřina Sobotková et al.
Studies in animal models and humans suggest that intentional exposure to helminths or helminth-derived products may hold promise for treating chronic inflammatory-associated diseases (CIADs). Although the mechanisms underlying 'helminth the...
Derek M McKay,Mindi Summers,Andre G Buret et al.
Derek M McKay et al.
Can We Recommend Practical Interventions to Prevent Neurocysticercosis? [0.03%]
我们能够推荐实用的预防神经囊尾蚴病干预措施吗？
Uffe Christian Braae,Marshall W Lightowlers,Meritxell Donadeu
Uffe Christian Braae
The cystiSim model was used to compare strategies for the control of Taenia solium. A three-monthly intervention in pigs for 3 years was substantially more effective than biannual treatment for taeniasis in the human population for 5 years....
Blood-Brain Barrier in Cerebral Malaria: Pathogenesis and Therapeutic Intervention [0.03%]
脑疟疾中的血脑屏障：发病机制与治疗干预
Gopala Nishanth,Dirk Schlüter
Gopala Nishanth
Cerebral malaria is a life-threatening complication of malaria caused by the parasite Plasmodium falciparum. The growing problem of drug resistance and the dearth of new antiparasitic drugs are a serious threat to the antimalaria treatment ...