Antigen presentation at the blood-brain barrier amplifies neuroinflammation [0.03%]
脑脊液中的抗原呈递放大神经炎症反应
Sidar Aydin,Javier Pareja,Roland Liblau et al.
Sidar Aydin et al.
Immune surveillance of the central nervous system (CNS) is regulated by the brain barriers. Antigen presentation at the blood-brain barrier (BBB) has been proposed to promote antigen-specific T-cell entry into the CNS, largely based on in v...
Emergency granulopoiesis and innate immune memory in inflammatory bowel disease [0.03%]
炎症性肠病中的应急粒细胞生成和先天免疫记忆
Sílvia Pires,Randy S Longman
Sílvia Pires
Emerging evidence now points to innate tissue immunity as a critical orchestrator of both local tissue adaptation and long-range hematopoietic reprogramming, including the amplification of emergency granulopoiesis through bone marrow progen...
Sidonia Eckle
Sidonia Eckle
Qianzhao Ji,Guang-Hui Liu,Jing Qu
Qianzhao Ji
Spatial multi-omics of aging human lymph nodes by Fan and colleagues reveals that immunosenescence manifests as focal B cell coalescence into 'SenSpots' within germinal centers, where concerted epigenetic, transcriptional, proteomic, and me...
Daniel T Utzschneider,Stephen J Turner
Daniel T Utzschneider
CD8+ T cell exhaustion is increasingly recognized as a regulated adaptation to chronic antigenic stimulation rather than a simple immune failure. Indeed, recent studies reveal that exhaustion is imprinted early after T cell activation, inte...
Xiaoting Wu,Jacques Behmoaras
Xiaoting Wu
Homing pigeons' navigation in darkness relies on Earth's magnetic field. However, the underlying mechanism of magnetoreception remains poorly understood. Recently, Lisowski et al. demonstrated that superparamagnetic hepatic macrophages are ...
Marta Crespi Sallan
Marta Crespi Sallan
Yazmina Quintana-Perez,Livia Lacerda Mariano,Ana-Maria Lennon-Duménil
Yazmina Quintana-Perez
More than 4 decades after the discovery of MHC restriction, it is clear that the phagocytosis of dying cells is not the only route by which macrophages acquire antigens. Fan and colleagues further expand this paradigm by showing that macrop...
Functional heterogeneity of macrophages in distinct niches of hepatocellular carcinoma [0.03%]
肝细胞癌不同生态位中巨噬细胞的功能异质性
Jinglong Guo,Jing Li,Laetitia Comps-Agrar et al.
Jinglong Guo et al.
Hepatocellular carcinoma (HCC) remains one of the most lethal malignancies, characterized by a highly complex and dynamic tumor microenvironment in which tumor-associated macrophages (TAMs) are particularly abundant. TAMs regulate tumor ini...
Biomaterial-guided macrophage modulation: Therapeutic engineering of immune microenvironments [0.03%]
生物材料引导的巨噬细胞重编程：免疫微环境的治疗工程学
Jordan Popov,Andreas Patsalos,Hai-Quan Mao et al.
Jordan Popov et al.
Macrophages are central regulators of immunity, tissue homeostasis, and repair, whose plasticity enables them to integrate cues from their local microenvironment. Dysregulated macrophages contribute to chronic inflammation, fibrosis, impair...