Effects of protein glycation and protective mechanisms against glycative stress [0.03%]
蛋白质糖基化及其抗糖化应激的保护机制
Jade A Najjar,John W Calvert
Jade A Najjar
Glycation is a posttranslational modification of proteins that contributes to the vast array of biological information that can be conveyed via a singular proteome. Understanding the role of advanced glycation end-products (AGEs) in human h...
Pharmaceutical therapies targeting autophagy for the treatment of age-related macular degeneration [0.03%]
针对年龄相关性黄斑变性的药物自噬治疗
Kirstan A Vessey,Andrew I Jobling,Ursula Greferath et al.
Kirstan A Vessey et al.
Age-related macular degeneration (AMD) is a major cause of irreversible vision loss in the elderly. Although new therapies have recently emerged, there are currently no ways of preventing the development of the disease. Changes in intracell...
Shaping DNA damage responses: Therapeutic potential of targeting telomeric proteins and DNA repair factors in cancer [0.03%]
塑造DNA损伤应答：靶向端粒蛋白和DNA修复因子的癌症治疗潜力
Yu Bin Ng,Semih Can Akincilar
Yu Bin Ng
Shelterin proteins regulate genomic stability by preventing inappropriate DNA damage responses (DDRs) at telomeres. Unprotected telomeres lead to persistent DDR causing cell cycle inhibition, growth arrest, and apoptosis. Cancer cells rely ...
Editorial overview: Special issue on "Rheumatology: Therapeutic advances for autoimmune and musculoskeletal diseases" [0.03%]
综述评论：专题“风湿病学：自身免疫和肌肉骨骼疾病治疗进展”
Larry W Moreland,Kristine Kuhn
Larry W Moreland
In the heart and beyond: Mitochondrial dysfunction in heart failure with preserved ejection fraction (HFpEF) [0.03%]
从心肌到更远端：心脏功能障碍在射血分数保留的心力衰竭中的作用
Nisha Bhattarai,Iain Scott
Nisha Bhattarai
Heart failure with preserved ejection fraction (HFpEF) is a major cardiovascular disorder with increasing prevalence and a limited range of targeted treatment options. While HFpEF can be derived from several different etiologies, much of th...
Martina Scano,Alberto Benetollo,Francesco Dalla Barba et al.
Martina Scano et al.
Sarcoglycanopathies are rare autosomal recessive diseases belonging to the family of limb-girdle muscular dystrophies. They are caused by mutations in the genes coding for α-, β-, γ-, and δ-sarcoglycan. The mutations impair the assembly...
From "contraindicated" to "first line" - Current mechanistic insights beyond canonical β-receptor signaling [0.03%]
从“禁忌”到“一线”- 超出规范β受体信号转导的当前机制见解
Theresa Brand,Ann-Kathrin Lukannek,Valérie Jahns et al.
Theresa Brand et al.
β-blockers are a solid pillar in the treatment of cardiovascular diseases. However, they are highly discussed regarding effectiveness for certain indications and side-effects. Even though there are up to 20 licensed compounds, only four ar...
The complement pathway as a therapeutic target for neovascular age-related macular degeneration-mediated subretinal fibrosis [0.03%]
补体途径作为治疗新生血管年龄相关性黄斑变性介导的视网膜下纤维化的作用靶点
Heping Xu,Caijiao Yi,Mei Chen
Heping Xu
Neovascular age-related macular degeneration (nAMD) is the leading cause of blindness in the elderly in developed countries. Intravitreal injection of VEGF inhibitors is the mainstream therapy for nAMD, although nearly 50% of the patients d...
Targeting TRP channels for pain relief: A review of current evidence from bench to bedside [0.03%]
靶向瞬时受体电位通道镇痛：从实验台到病床的现有证据综述
Ari-Pekka Koivisto,Thomas Voets,Michael J Iadarola et al.
Ari-Pekka Koivisto et al.
Several decades of research support the involvement of transient receptor potential (TRP) channels in nociception. Despite the disappointments of early TRPV1 antagonist programs, the TRP family remains a promising therapeutic target in pain...
Estrogen related receptor alpha: Potential modulator of age-related macular degeneration [0.03%]
雌激素相关受体alpha：可能调控年龄相关性黄斑变性的因素
Fatima Massare Somers,Goldis Malek
Fatima Massare Somers
To develop effective therapies for complex blinding diseases such as age-related macular degeneration (AMD), identification of mechanisms involved in its initiation and progression is needed. The estrogen-related receptor alpha (ESRRA) is a...