Matthew P Connor,Adam Barsouk,Omar Elghawy et al.
Matthew P Connor et al.
For decades, the only therapeutic option for acute myeloid leukemia (AML) had been intensive combination chemotherapy. In recent years, understanding of the molecular mechanisms underlying myeloid oncogenesis has grown immensely and has led...
Sheng-Tao Hou
Sheng-Tao Hou
TMEM16A regulates MUC5AC production in airway diseases: A comprehensive review [0.03%]
TMEM16A在呼吸系统疾病中调节MUC5AC的产生：全面综述
Jintao Gan,Xiaochun Huang,Danli Zhu et al.
Jintao Gan et al.
Abnormal secretion of the airway mucin MUC5AC is a key pathological feature in the pathologic process of airway diseases, overproduction of MUC5AC leads to airway mucus accumulation and airway obstruction, which further triggers respiratory...
Targeting strategies and immune regulatory mechanisms of CAR-macrophages in the treatment of osteosarcoma [0.03%]
CAR-巨噬细胞靶向策略及免疫调控机制在骨肉瘤治疗中的作用研究
Rongrong Chai
Rongrong Chai
Osteosarcoma (OS), the most common primary malignant bone tumor, poses significant clinical challenges owing to its high metastatic potential and resistance to chemotherapy. Although Chimeric Antigen Receptor T-Cell Immunotherapy (CAR-T) ha...
Modulating neuroimmune function: The key in taVNS therapy for neurological and psychiatric disorders [0.03%]
调神经免疫功能：头颈部迷走神经刺激治疗神经系统和精神障碍的关键因素
Xinjiang Zhang,Qi Zou,Jinling Zhang et al.
Xinjiang Zhang et al.
Numerous lines of evidence indicate that the inflammatory state of neural tissue plays a significant role in the pathogenesis of neurological and psychiatric disorders, with neuroinflammation contributing to the dysregulation of cellular im...
Lipidomics-driven insights into acupuncture mechanisms: From dynamic signaling networks to multi-dimensional regulations [0.03%]
脂质组学驱动的针刺机制研究：从动态信号网络到多维度调控
Xi Ruan,Junqi Zhou,Lizhexiong Song et al.
Xi Ruan et al.
This review summarizes lipidomics as a key approach to dissect the multi-dimensional regulatory mechanisms of acupuncture, and reveals the role of lipid networks serve as critical 'molecular transducers' in the conversion of mechanical stim...
AI-powered intestinal ultrasound in inflammatory bowel disease: Advancing toward automated disease assessment [0.03%]
人工智能在炎症性肠病肠超声中的应用：迈向疾病评估的自动化
Irene Zammarchi,Olga Maria Nardone,Rosanna Cannatelli et al.
Irene Zammarchi et al.
The management of inflammatory bowel disease (IBD) relies on accurate disease assessment and close monitoring to guide therapy and evaluate treatment response. While endoscopy remains the gold standard for detecting mucosal inflammation, it...
The underlying mechanisms of acupuncture for alleviating pain-induced negative emotions: Synergistic regulation of multiple brain regions [0.03%]
针刺缓解疼痛诱导的负性情绪的作用机制研究：多脑区协同调节作用探讨
Zhen Liu,Chaoyang Zhang,Zelin Chen et al.
Zhen Liu et al.
Brain regions associated with pain perception also subsume those involved in emotional regulation, which likely constitutes the physiological basis underlying the comorbidity of pain and negative emotions. Acupuncture has unique advantages ...
Electro-microbial interplay in the gut-brain axis: An emerging paradigm for gut microbiota modulation via vagus nerve stimulation [0.03%]
肠道-大脑轴中的电微生物相互作用：通过迷走神经刺激调节肠道菌群的新范式
Jingwen Liang,Xiunan Li,Chunyang Mao et al.
Jingwen Liang et al.
The treatment of central nervous system disorders remains a clinical challenge, highlighting an urgent need for innovative therapeutic strategies. The gut-brain axis represents a complex bidirectional communication network between the gastr...
The role of plant-derived compounds in anti-obesity drug discovery: A molecular perspective [0.03%]
植物源化合物在抗肥胖药物发现中的作用：分子视角分析
Vetriselvan Subramaniyan,Ram Narayanan Ravi,Sammra Maqsood et al.
Vetriselvan Subramaniyan et al.
Obesity is a complex and multifaceted disease associated with metabolic diseases and severe health problems worldwide. There is an urgent need for novel therapeutic strategies since the currently available treatment options are often ineffe...