Tehreem Ikram,Ammara Zamir,Abdul Majeed et al.
Tehreem Ikram et al.
Background: Afatinib is commonly used in the treatment of non-small cell lung cancer (NSCLC). This systematic review summarizes clinical pharmacokinetics (PK) evidence focusing on the effect of disease state and drug inte...
Glymphatic dysfunction in neurodegeneration: From impaired clearance to mechanism-driven therapeutic innovation [0.03%]
神经退行性疾病中的糖淋巴系统功能障碍：从清除受阻到靶向治疗创新机制研究
Palak Kalra,Amarjot Kaur Grewal
Palak Kalra
Glymphatic system refers to a system that involves perivascular clearance mechanisms within the brain, which are crucial for the elimination of neurotoxic proteins such as amyloid-β (Aβ) and tau proteins in Alzheimer's disease (AD), α-sy...
Targeting the ischemic cascade: Review on approved and investigational stroke therapies [0.03%]
针对缺血级联反应的靶点：已获批和研究中的卒中治疗药物综述
Ruoyu Wang,Zixuan Qiu,Jian Chen et al.
Ruoyu Wang et al.
Ischemic stroke persists as a preeminent global health burden, ranking among the foremost causes of both mortality and long-term disability worldwide. This significant disease burden underscores its critical status within international publ...
Senotherapeutic strategies for ovarian aging: Mechanistic insights and translational perspectives [0.03%]
卵巢衰老的细胞 senotherapeutics策略：机制见解和转化视角
Alaa M Alsirhani,Mohammad El-Nablaway,Tarek A Yousef et al.
Alaa M Alsirhani et al.
Ovarian aging manifests as progressive depletion of the primordial follicle reserve and declining oocyte quality, culminating in menopause and associated systemic comorbidities. Cellular senescence emerges as a central driver of this proces...
Chrono-immunotherapy in precision oncology: Circadian control of the tumor microenvironment and time-of-day optimization of immune checkpoint blockade [0.03%]
精准肿瘤学中的chrono-免疫治疗：昼夜节律调控肿瘤微环境和免疫检查点阻断的每日最佳给药时间优化策略
Mohammad El-Nablaway,Ghaith Koushaji
Mohammad El-Nablaway
Chrono-immunotherapy has emerged as a compelling precision-oncology strategy based on the premise that immune checkpoint blockade is modulated by circadian biology. The immune system is organized across daily oscillations in leukocyte traff...
Methotrexate: Integrating molecular pharmacology, systems toxicology, and precision rescue strategies [0.03%]
甲氨蝶呤：整合分子药理学、系统毒理学和精准解救策略
Rasha Mokhtar Abdelkareem,Walaa Obydah,Ahmed M Abd-Eldayem
Rasha Mokhtar Abdelkareem
Methotrexate (MTX) remains a cornerstone therapy across oncology, rheumatology, dermatology, and reproductive medicine. Despite its long clinical history, MTX exhibits mechanistic complexity that extends far beyond classical antifolate acti...
Acupuncture and non-invasive neuromodulation-induced neuro-endocrine-immune changes associated with the amelioration of depression-like behaviors: A systematic review of animal studies [0.03%]
针刺和非侵入性神经调控诱导的神经营销改变与抑郁样行为改善相关的动物研究系统的回顾
Yiping Sun,Yupei Cheng,Yi Guo et al.
Yiping Sun et al.
Background: Depression involves multisystem alterations, including impaired neuroplasticity, inflammation, and dysregulation of immune and endocrine function. In animal studies, non-invasive regulatory interventions-such ...
Alopecia areata: Mechanisms, targeted therapies, and translational challenges [0.03%]
斑秃：机制、靶向治疗及转化挑战
Virender Kumar,Saurabh Sahoo,Pawan Kumar
Virender Kumar
Alopecia areata (AA) is an immune-mediated disorder characterized by non-scarring hair loss and substantial psychosocial burden. Although recent advances have clarified key pathogenic mechanisms and expanded therapeutic options, important u...
State-dependent neurotensin modulation in the brain: From network dynamics to pharmacological opportunity [0.03%]
脑中状态依赖性神经紧张素调节：从网络动力学到药理机会
Shengru Hu,Zixu Zhang,Wei Xie et al.
Shengru Hu et al.
Neurotensin (NT) is a conserved neuropeptide acting as a critical state-dependent neuromodulator across hypothalamic, limbic, and brainstem circuits. Historically categorized by discrete behavioral effects, recent spatial transcriptomic and...
Riluzole in neuroinflammation and neurodegeneration: Mechanistic insights and experimental validation [0.03%]
雷洛昔芬在神经炎症和神经退行性疾病中的作用机制及实验验证
Ahmed M Abd-Eldayem,Renad A Mohammed
Ahmed M Abd-Eldayem
Neuroinflammation and neurodegeneration are tightly interconnected processes that drive the progression of multiple central nervous system (CNS) disorders. Riluzole, a benzothiazole derivative approved for amyotrophic lateral sclerosis (ALS...