Hydroxytyrosol Mitigates Anxiety-Like Behaviors After a Traumatic Experience in Aged Mice in Parallel With Increased Neurogenesis in the Ventral and Dorsal Dentate Gyrus, and Preservation of Gut Microbiota Composition [0.03%]
对羟基苯丝氨酸通过增加齿状回腹侧和背侧神经元的生成以及保存肠道微生物组组成来缓解老年小鼠在创伤经历后的类似焦虑的行为
Giorgio D&#x;Andrea,Laura Bertini,Marco Costanzi et al.
Giorgio D&#x;Andrea et al.
Hydroxytyrosol (HTyr), a phenolic compound present in olive oil, exhibits antioxidant, anti-inflammatory, and neuroprotective properties, benefiting several age-related diseases. Our previous research demonstrated that oral HTyr administrat...
Urine-Derived iPSC Neurospheres Uncover Proteomic Correlates of Clinical Severity in Dravet Syndrome [0.03%]
尿液诱导多能干细胞神经球发现Dravet综合征临床严重程度的蛋白组标志物
Michele Martins,Guillaume Nugue,Andrey Aguiar et al.
Michele Martins et al.
Dravet syndrome (DS) is a rare and severe childhood-onset developmental epileptic encephalopathy caused primarily by mutations in the sodium channel gene SCN1A. Animal models have undeniably advanced our understanding of DS, but they still ...
Correction to "Targeting Glutamate Excitotoxicity with Memantine Modulates Glial Response and Protects Motoneurons After Spinal Root Lesion" [0.03%]
关于“用美金刚靶向 glutamate兴奋毒性对脊神经根损伤后的星形胶质细胞反应进行调节并保护运动神经元”的校正论文
Published Erratum
Journal of neurochemistry. 2026 May;170(5):e70453. DOI:10.1111/jnc.70453 2026
Cerebrospinal Fluid sCD27 as a Biomarker of Neuroinflammatory Disease: A Systematic Review and Meta-Analysis [0.03%]
脑脊液sCD27作为神经炎症性疾病生物标志物的系统评价和Meta分析
Nadia Damholt Savino,Malene Bredahl Hansen,Amanda Marie Lund Christiansen et al.
Nadia Damholt Savino et al.
Neuroinflammatory diseases of the central nervous system (CNS) present considerable diagnostic challenges due to overlapping clinical features and the lack of specific biomarkers capable of reliably detecting CNS inflammation. Soluble CD27 ...
Adenosine A2A Receptors Control the Mis-Localization of Aquaporin-4 in Rats Subject to Repeated Restraint Stress [0.03%]
腺苷A2A受体控制反复束缚应激大鼠Aquaporin-4的错定位分布
Liliana Dias,Samira G Ferreira,Ana Margarida Nabais et al.
Liliana Dias et al.
Repeated stress triggers anxiety accompanied by a deregulation of cortical glucocorticoid receptors, which is relieved by blocking adenosine A2A receptors (A2AR). A2AR also controls the glymphatic system and the polarization of its key driv...
Neonatal Overnutrition Induces Long-Lasting Hypothalamic POMC Silencing and Shapes Distinct Obesity Phenotypes According to Adult Dietary Environments [0.03%]
新生儿过营养诱导下丘脑POMC持续性去甲基化并根据成人饮食环境形成不同肥胖表型
Pamela Rocío Fernández,Luisa Gaydou,Rocío Schumacher et al.
Pamela Rocío Fernández et al.
Our study aimed to analyze the individual effects of early-life overnutrition (focusing on its long-lasting impact) and adult cafeteria diet (CAF) exposure, as well as their combined effect, on hypothalamic food-intake regulation. Neonatal ...
Kinetic Modeling of a Novel Putative Sphingosine-1-Phosphate Receptor 1 (S1PR1) Radiotracer [18F]TZ82112 in Nonhuman Primates [0.03%]
新型拟靶向鞘氨醇-1-磷酸受体1（S1PR1）放射示踪剂[18F]TZ82112的非人灵长类动物动力学模型研究
Ying-Hwey Nai,Lin Qiu,Hao Jiang et al.
Ying-Hwey Nai et al.
Sphingosine-1-phosphate receptors (S1PRs) play an important regulatory role in various biological processes, including immune responses and neurodegeneration. We report the binding specificity of an S1PR1 PET radiotracer, [18F]TZ82112, via ...
Validation of TRPA1 and TRPV1 Antibodies for Expression Detection in Mammalian Cells and Tissues [0.03%]
用于检测哺乳动物细胞和组织中TRPA1和TRPV1表达的抗体验证
M de Las Casas,P Hernández-Ortego,R Torres-Montero et al.
M de Las Casas et al.
Antibodies are key reagents in cell biology and biochemistry research. The validation of their performance, in terms of sensitivity and specificity, is essential for their correct application. TRPV1 and TRPA1 are non-selective cation channe...
Claudia Duran-Aniotz,Matias Pizarro,Joaquin Migeot et al.
Claudia Duran-Aniotz et al.
Blood-based biomarkers (BBMs) are transforming the diagnostic landscape of Alzheimer's disease by enabling scalable, less invasive, and potentially earlier biological characterization. However, most evidence supporting their performance, in...
Antisense Oligonucleotides in Parkinson's Disease: Challenges, Opportunities, and the Promise of Low-Intensity Focused Ultrasound for Brain Delivery [0.03%]
低强度聚焦超声促进寡核苷酸药物治疗帕金森病的研究挑战、机遇及前景
Shunsuke Obika,Javier Blesa
Shunsuke Obika
Parkinson's disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuronal loss in the basal ganglia, for which no disease modifying therapy is currently available. Antisense oligonucleotides (ASOs) have emerged as prom...