Cerebrospinal Fluid sCD27 as a Biomarker of Neuroinflammatory Disease: A Systematic Review and Meta-Analysis [0.03%]
脑脊液sCD27作为神经炎症性疾病生物标志物的系统评价和Meta分析
Nadia Damholt Savino,Malene Bredahl Hansen,Amanda Marie Lund Christiansen et al.
Nadia Damholt Savino et al.
Neuroinflammatory diseases of the central nervous system (CNS) present considerable diagnostic challenges due to overlapping clinical features and the lack of specific biomarkers capable of reliably detecting CNS inflammation. Soluble CD27 ...
Adenosine A2A Receptors Control the Mis-Localization of Aquaporin-4 in Rats Subject to Repeated Restraint Stress [0.03%]
腺苷A2A受体控制反复束缚应激大鼠Aquaporin-4的错定位分布
Liliana Dias,Samira G Ferreira,Ana Margarida Nabais et al.
Liliana Dias et al.
Repeated stress triggers anxiety accompanied by a deregulation of cortical glucocorticoid receptors, which is relieved by blocking adenosine A2A receptors (A2AR). A2AR also controls the glymphatic system and the polarization of its key driv...
Neonatal Overnutrition Induces Long-Lasting Hypothalamic POMC Silencing and Shapes Distinct Obesity Phenotypes According to Adult Dietary Environments [0.03%]
新生儿过营养诱导下丘脑POMC持续性去甲基化并根据成人饮食环境形成不同肥胖表型
Pamela Rocío Fernández,Luisa Gaydou,Rocío Schumacher et al.
Pamela Rocío Fernández et al.
Our study aimed to analyze the individual effects of early-life overnutrition (focusing on its long-lasting impact) and adult cafeteria diet (CAF) exposure, as well as their combined effect, on hypothalamic food-intake regulation. Neonatal ...
Kinetic Modeling of a Novel Putative Sphingosine-1-Phosphate Receptor 1 (S1PR1) Radiotracer [18F]TZ82112 in Nonhuman Primates [0.03%]
新型拟靶向鞘氨醇-1-磷酸受体1（S1PR1）放射示踪剂[18F]TZ82112的非人灵长类动物动力学模型研究
Ying-Hwey Nai,Lin Qiu,Hao Jiang et al.
Ying-Hwey Nai et al.
Sphingosine-1-phosphate receptors (S1PRs) play an important regulatory role in various biological processes, including immune responses and neurodegeneration. We report the binding specificity of an S1PR1 PET radiotracer, [18F]TZ82112, via ...
Validation of TRPA1 and TRPV1 Antibodies for Expression Detection in Mammalian Cells and Tissues [0.03%]
用于检测哺乳动物细胞和组织中TRPA1和TRPV1表达的抗体验证
M de Las Casas,P Hernández-Ortego,R Torres-Montero et al.
M de Las Casas et al.
Antibodies are key reagents in cell biology and biochemistry research. The validation of their performance, in terms of sensitivity and specificity, is essential for their correct application. TRPV1 and TRPA1 are non-selective cation channe...
Claudia Duran-Aniotz,Matias Pizarro,Joaquin Migeot et al.
Claudia Duran-Aniotz et al.
Blood-based biomarkers (BBMs) are transforming the diagnostic landscape of Alzheimer's disease by enabling scalable, less invasive, and potentially earlier biological characterization. However, most evidence supporting their performance, in...
Antisense Oligonucleotides in Parkinson's Disease: Challenges, Opportunities, and the Promise of Low-Intensity Focused Ultrasound for Brain Delivery [0.03%]
低强度聚焦超声促进寡核苷酸药物治疗帕金森病的研究挑战、机遇及前景
Shunsuke Obika,Javier Blesa
Shunsuke Obika
Parkinson's disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuronal loss in the basal ganglia, for which no disease modifying therapy is currently available. Antisense oligonucleotides (ASOs) have emerged as prom...
A Comprehensive Characterization of the Phospholipid and Cholesterol Composition of the Uncinate Fasciculus in the Human Brain: Evidence of Age-Related Alterations [0.03%]
人脑钩束磷脂和胆固醇组成的特点及年龄相关变化的证据
Kelly Perlman,Chuck T Chen,Mackenzie E Smith et al.
Kelly Perlman et al.
The uncinate fasciculus (UF) is a long-range association fiber tract connecting the anterior temporal lobe with the orbitofrontal cortex and has been linked to a multitude of physiological and pathophysiological conditions such as aging, ep...
Schwann Cells in Development, Regeneration, and Therapeutic Applications: Insights From the Sciatic Nerve Model [0.03%]
雪旺细胞在发育、再生和治疗应用中的作用：来自坐骨神经模型的见解
Vanina Usach,Paula A Soto,C Patricia Setton-Avruj
Vanina Usach
The sciatic nerve is the largest nerve in the human body and is frequently affected by lesions, causing pain and even loss of sensitivity. The sciatic nerve injury model provides a robust platform to study the degeneration-regeneration proc...
Peri-Microvascular Glycogen and Lactate Regulate Capillary Constrictions and Ischemia Outcome in Mice [0.03%]
小鼠周围微血管糖原和乳酸调节毛细血管收缩及缺血结局
Gokhan Uruk,Buket Donmez-Demir,Sinem Yilmaz-Ozcan et al.
Gokhan Uruk et al.
Ischemic stroke results in sudden blood flow cessation, thus unmet energy requirements. Glycogen stored around peri-microvascular astrocyte end-feet may mediate capillary contractility and cerebral blood flow alterations. Under glucose-depr...