Curving Actin Across Systems: Do Axonal Actin Rings Share Common Underlying Mechanisms? [0.03%]
弯曲的肌动蛋白跨系统作用：轴突肌动蛋白环是否具有共同的基本机制？
Ana Rita Costa,Luís P Rodrigues,Monica M Sousa
Ana Rita Costa
Actin polymerization into curved and ring-shaped structures is an evolutionarily conserved mechanism that cells use to generate force, transmit tension, and maintain membrane architecture. In neurons, super-resolution imaging has revealed a...
High-Resolution Elemental Analysis of Neuromelanin-Containing Organelles in Human Locus Coeruleus [0.03%]
人脑蓝斑中含神经黑素细胞器的高分辨率元素分析
Zahraa Berro,Fabio A Zucca,Maria Angels Subirana et al.
Zahraa Berro et al.
Neuromelanin-(NM) containing organelles are sub-cellular auto-lysosomal structures composed of three main compartments: NM pigment, protein matrix, and lipid bodies. These organelles accumulate during aging and are found predominantly in th...
Effect of Prenatal and Postnatal Stress in Rats on the Gut Microbiome in Adolescence [0.03%]
大鼠产前和产后压力对青少年肠道菌群的影响
Rebecca Woods,Elliot F Jennings,Laura Smith et al.
Rebecca Woods et al.
Previous research suggests that early-life stress (ELS) increases the risk of mental health disorders later in life. It is hypothesised that ELS disrupts the developing gut microbiome, which in turn may alter neuroendocrine and immune syste...
Developmentally Regulated Expression and Activity of Sulphotransferases in the Rat Choroid Plexuses [0.03%]
大鼠脉络丛中硫酸转移酶的发育调控表达和活性
Fiona Qiu,Nathalie Strazielle,Anne Denuziere et al.
Fiona Qiu et al.
During development, entry of any substances from the circulation into the brain is tightly regulated by a series of blood-brain interfaces. Notably, the choroid plexuses, which form the blood-cerebrospinal fluid barrier, serve as a key inte...
Unconventional Protein Secretion in the Central Nervous System: Mechanisms and Roles in Physiology and Disease [0.03%]
中枢神经系统的非常规蛋白质分泌：机制及其在生理和疾病中的作用
Steven A Krauklis,Sevnur Kömürlü Keçeli,Edward M Campbell et al.
Steven A Krauklis et al.
Extracellular secretion of neurotransmitters, proteins, and peptides by cells of the central nervous system underpins neurological function and homeostasis. Decades of elegant research have illuminated the molecular mechanisms and machinery...
Limitations and Strengths of the SH-SY5Y Neuroblastoma Cell Line as a Model of β-Amyloid Neurotoxicity: Lessons From a Systematic Review and Meta-Analysis [0.03%]
SH-SY5Y神经母细胞瘤细胞系作为β淀粉样蛋白神经毒性的模型的局限性和优势：系统评价和Meta分析的启示
Nathalia R Pinheiro,Clarissa F D Carneiro,Giulia S Cancelliero et al.
Nathalia R Pinheiro et al.
The SH-SY5Y human neuroblastoma cell line is widely used as an in vitro model of β-amyloid (Aβ) neurotoxicity in Alzheimer's disease (AD). However, the lack of standardized protocols for assessing Aβ toxicity-including differentiation st...
APP/Aβ Signaling Orchestrates Reactive Astrocyte Networks in Alzheimer's Disease [0.03%]
APP/Aβ信号调控阿尔茨海默病中的反应性星形胶质细胞网络
Gretsen Velezmoro Jauregui,Sophie Coomes,Elizabeth Emmett et al.
Gretsen Velezmoro Jauregui et al.
Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) accumulation, neurofibrillary pathology, synaptic dysfunction, and chronic neuroinflammation, yet the mechanisms driving early, localized pathology remain elusive. While traditio...
Activation of GCaMP6f-Expressing Chromaffin and Satellite Glial Cells in Murine Adrenal Slices by Nanosecond Electric Pulses [0.03%]
纳秒电脉冲活化小鼠肾上腺切片中GCaMP6f表达的嗜铬细胞和卫星神经胶质细胞
Ciara Viola,Lisha Yang,Vasilii Mansurov et al.
Ciara Viola et al.
Nanosecond electric pulses (NEP) are being explored as a novel bioelectric stimulus to modulate neurosecretion. Recently we reported that NEP trigger transient, voltage-gated Ca2+ channel-mediated Ca2+ influx in cultured murine adrenal chro...
Shiwani Kumari,Roberto Pagano,Katarzyna Orzol et al.
Shiwani Kumari et al.
The mammalian target of rapamycin (mTOR) is a key regulator of neuronal development, metabolism, and plasticity, and its dysregulation is linked to many neurological disorders. Most studies have focused on cytoplasmic mTOR, yet mTOR is also...
Early Hypo-Osmolar Stress Regulates Astrocyte Reactivity After Brain Injury: "New Insights Into Glial Response to Edema" [0.03%]
早期低渗应力调节脑损伤后的星形胶质细胞活化——水肿引起的胶质反应新见解
Camila Vidos,Matías Monteverde Busso,Azul Millán et al.
Camila Vidos et al.
Astrocytes are among the first cellular responders to central nervous system injury, yet the mechanisms governing their earliest responses remain incompletely understood. Here, we investigated astrocyte dynamics during the first hours after...