Astrocytes in Brain Aging and Neurodegeneration: Cellular Mechanisms and Interventional Strategies [0.03%]
脑衰老与神经退行性疾病的胶质细胞机制及干预策略研究
Flávia C A Gomes,Isadora Matias
Flávia C A Gomes
Aging is characterized by progressive changes in the physiology of brain cells, which may contribute to cognitive decline, ultimately leading to dementia and impaired quality of life. The increase in senescent cells, including glial cells i...
Unveiling the Molecular Mechanism of Intestinal Metabolite para-Cresol in Modulating Neuroinflammation and Synaptic Dysfunction: Implications for Autism Spectrum Disorder [0.03%]
肠道代谢产物对羟基苯甲醛通过调控神经炎症和突触功能障碍的分子机制作用于孤独症谱系疾病的分子机制研究
Wenjie Liao,Kristy Antonioni,Federica Silvestri et al.
Wenjie Liao et al.
Autism spectrum disorder (ASD) is a diverse group of neurodevelopmental disorders that share similar behavioral patterns. Many individuals with ASD also exhibit gastrointestinal disturbances, likely linked to alterations in the composition ...
Correction to "Hydroxytyrosol Mitigates Anxiety-Like Behaviors After a Traumatic Experience in Aged Mice in Parallel With Increased Neurogenesis in the Ventral and Dorsal Dentate Gyrus, and Preservation of Gut Microbiota Composition" [0.03%]
关于“羟基酪醇通过增加齿状回腹侧和背侧神经发生并保持肠道微生物组组成来减轻老年小鼠创伤后类似焦虑的行为”的更正通知
Published Erratum
Journal of neurochemistry. 2026 May;170(5):e70471. DOI:10.1111/jnc.70471 2026
Ralf Dringen,Sandra J Hewett,Alessandro Prinetti et al.
Ralf Dringen et al.
Low 5HT1B and 5HT4 Receptor Neurotransmission as a Potential Link Between Cholesterol Metabolism and Suicide Risk [0.03%]
血清胆固醇代谢与自杀风险的神经生物学机制研究进展
Hans O Kalkman,Lukasz Smigielski
Hans O Kalkman
Elevated levels of the inflammatory cytokine IL-6 and decreased levels of cholesterol in blood and brain tissue have been reported in studies of individuals who attempted or completed suicide. The mechanisms underlying these effects remain ...
Anti-Aging Protein Klotho Attenuates Schizophrenia-Associated Cognitive and Synaptic Dysfunctions by Regulating GluN2B-NMDARs in the Hippocampus [0.03%]
抗衰老蛋白Klotho通过调节海马区GluN2B-NMDARs来缓解精神分裂症相关的认知和突触功能障碍
Jin-Qiong Zhan,Yi-Heng Li,Fu-Hao Jiang et al.
Jin-Qiong Zhan et al.
Cognitive impairment is a core symptom of schizophrenia and has a significant impact on clinical efficacy and prognosis. However, its underlying pathological mechanism remains unclear and effective treatments are still lacking. N-methyl-D-a...
Insulin Receptor Isoform Pattern in Aged Normal and Alzheimer's Human Cortex [0.03%]
人正常和阿尔茨海默氏病人大脑皮层的胰岛素受体异构形式模式分析
Catherine Webb-Robinson,Helen Murray,Clinton P Turner et al.
Catherine Webb-Robinson et al.
Desensitisation to insulin nearly doubles the risk of developing Alzheimer's disease (AD), a degenerative brain disorder and the leading cause of dementia. Impairment of the insulin signalling pathway is also apparent in AD brain tissue eve...
Modeling Synaptic Maturation From Growth Cone to Synapse in Human Organoids [0.03%]
人类类器官中生长锥到突触的成熟模型构建研究
Marie S Øhlenschlæger,Lucrezia Criscuolo,Pia Jensen et al.
Marie S Øhlenschlæger et al.
Human neural organoids (NOs) provide a powerful platform for investigating synaptic development and dysfunction during early neurodevelopment. However, methodologies for isolating functional synaptic structures from these models remain limi...
Circulating Sphingomyelins Correlate With Plasma T-Tau in Cognitively Unimpaired Older Adults at Risk of Developing Alzheimer's Disease [0.03%]
循环鞘磷脂与有发展阿尔茨海默病风险的无认知障碍老年人血浆T-tau的相关性
Tahmida Sharmin,James D Doecke,Pratishtha Chatterjee et al.
Tahmida Sharmin et al.
Alterations in plasma sphingomyelin (SM) levels have been reported in Alzheimer's disease (AD), pointing to disturbances in lipid metabolism that may contribute to disease pathogenesis. Neuronal damage in early AD triggers tau release into ...
Chromaffin Versus Platelet Granules: What We Have Learned From Chromaffin Cells for Human Studies [0.03%]
肾上腺素能染色质 Afffinity 染色颗粒与血小板致密颗粒：从嗜铬细胞中我们学到了什么以及对人类研究的影响
Ricardo Borges
Ricardo Borges
Biological amines-such as dopamine, norepinephrine, epinephrine, octopamine, serotonin, and histamine-are stored at high concentrations within secretory vesicles, also referred to as "granules" in certain cell types, including mast cells, c...