Iker Bengoetxea de Tena,Farhanah Nabilah Sallie,Arvie Rodriguez Abiero et al.
Iker Bengoetxea de Tena et al.
Neuropsychiatric disorders represent a significant global health burden. Despite decades of research, current treatments typically provide only symptomatic relief, rather than addressing the underlying mechanisms of these conditions. Histor...
The Chromatin-Modifying Protein RCOR2/CoREST2 Safeguards Axon-Dendrite Growth and Microtubule Stability in Brain Neurons [0.03%]
染色质修饰蛋白RCOR2/CoREST2通过稳定神经元微管来保障脑源性神经营养因子介导的轴突-树突生长和稳定性
Carlos Wilson,Victoria Rozés-Salvador,José F Drube et al.
Carlos Wilson et al.
Understanding the mechanisms that underlie neuronal dynamics is crucial to promoting brain health. The chromatin-modifying protein RCOR2 (also named CoREST2) has recently gained attention for its neuroprotective roles. Although previous wor...
Exocytosis, Endocytosis, and Replenishment of the Immediately Releasable Pool of Secretory Vesicles. Possible Physiological Relevance in Chromaffin Cells [0.03%]
分泌颗粒的胞外运输、胞内运输和即时可释放池的补充。肾上腺素能细胞中的可能生理相关性
Fernando D Marengo
Fernando D Marengo
In neuroendocrine cells, the fusion of secretory vesicles to the plasma membrane is triggered by a localized increase in cytosolic Ca2+ concentration, which occurs following the activation of voltage-dependent Ca2+ channels. However, there ...
N,N-Dimethyltryptamine (DMT) Acutely Exposed to Mouse Ventral Tegmental Area Ih-Negative Neurons Alters the Firing Rate and Conductance in a Sex-Dependent Manner [0.03%]
N,N-二甲基色胺（DMT）急性暴露于小鼠腹中束核Ih阴性神经元以性别依赖的方式改变放电率和传导率
Jannik Nicklas Eliasen,Amir Rezagholizadeh,Helene Påbøl Jacobsen et al.
Jannik Nicklas Eliasen et al.
Depression and substance use disorder (SUD) affect millions globally and unfortunately, while established treatments exist, they are not always adequate. Psychedelics have emerged as a promising avenue for development of more effective phar...
Dualsteric Agonist for M2 Muscarinic Receptor Causes Oxidative Stress and Mitochondrial Alteration in Human Glioblastoma Cancer Stem Cells [0.03%]
M2胆碱能受体双STERIC激动剂导致人胶质母细胞瘤癌症干细胞氧化应激和线粒体改变
Claudia Guerriero,Chiara De Nuccio,Maria Petrone et al.
Claudia Guerriero et al.
Glioblastoma (GB) is the most malignant form of human brain tumor, characterized by heterogeneous cell populations, including undifferentiated cells defined as GB stem cells (GSCs), responsible for initiating the neoplastic process as well ...
Prenatal Methyl Nutrient Availability Shapes Mesolimbic Dopaminergic Circuitry and Systemic Inflammation in Wistar Rat Offspring of Both Sexes [0.03%]
宫内甲基营养物质的可用性影响威斯忒大鼠后代的中脑边缘多巴胺能环路和全身炎症反应（男女均有此效应）
Cassia Di Pierdomenico,William J J Cook,Jianzhang Dong et al.
Cassia Di Pierdomenico et al.
The dopaminergic system constitutes a principal element of the reward neurocircuitry and is responsive to influences encountered early in life. Methylation potential, shaped by nutrients involved in one-carbon metabolism, intersects with im...
A High-Throughput Assay for Monitoring and Quantifying Amyloid-β Accumulation and Clearance in Alzheimer's Disease Cell Models [0.03%]
一种用于监测和定量阿尔茨海默病细胞模型中淀粉样蛋白-β积累和清除的高通量测定法
Ajish Ariyath,Fraulein Denise Arigo,Anna Fyfe et al.
Ajish Ariyath et al.
Amyloidogenic proteins, such as amyloid-β (Aβ), self-assemble into cross-β fibrils whose accumulation is central to Alzheimer's disease (AD). Measuring Aβ aggregation and clearance in living cells remains challenging using current cell-...
Seed Amplification Assays for Parkinson's Disease: A Review of α-Synuclein Assays in Body Fluids and Tissues [0.03%]
帕金森病种子放大试验综述：体液和组织中α-突触核蛋白实验
Weijie Kong,Katsuya Satoh,Mika Inada Shimamura et al.
Weijie Kong et al.
The pathological core of Parkinson's disease and related synucleinopathies involves the misfolding and aggregation of α-synuclein. Seed amplification assays (SAAs) have revolutionized the detection of pathological α-synuclein by enabling ...
Systematic Characterisation of GLP-1R in Human Enteric Nervous System: Implications for GLP-1 as a Key Regulator of Colonic Activity [0.03%]
人肠神经系统GLP-1受体的系统表征：GLP-1作为结肠活动关键调节因子的意义
Kiran Devi Dontamsetti,Rubina Aktar,Madusha Peiris
Kiran Devi Dontamsetti
Glucagon-like peptide-1 (GLP-1) regulates glucose homeostasis, satiety and gastrointestinal (GI) motility through interaction with its receptor (GLP-1R). While central GLP-1 pathways are well studied, the distribution and functional role of...
Muscarine, Pituitary Adenylate Cyclase Activating Polypeptide, and Angiotensin II-Evoked Secretion in Adrenal Medullary Chromaffin Cells With a Major Focus on TRPC Channels [0.03%]
Muscarine、PACP和血管紧张素II促肾上腺素能细胞分泌的作用及主要由TRPC通道介导的信号转导路径研究进展
Masumi Inoue,Keita Harada
Masumi Inoue
Adrenal medullary chromaffin (AMC) cells secrete catecholamines in response to neuronal and humoral inputs during stress. Secreted adrenaline is crucial for organismal survival during acute and/or chronic stress, primarily through the stimu...