Deep Brain Stimulation of the Nucleus Accumbens Modulates Effort-Based Decision-Making and Phasic Dopamine Release in Male Wistar Rats [0.03%]
针对雄性威斯特大鼠伏隔核的深部脑刺激调节基于努力的选择决策和多巴胺的爆发式释放
Sebastian McCullough,Roger B Varela,Tristan Houghton et al.
Sebastian McCullough et al.
The initiation and sustained expression of motivated behaviour is strongly regulated by mesolimbic dopamine (DA) release within the nucleus accumbens (NAc). Deep brain stimulation (DBS) has demonstrated efficacy in treating refractory psych...
SARS-CoV-2 Infection Induces Dopaminergic Neuronal Loss in Midbrain Organoids [0.03%]
新冠病毒感染诱导中脑类器官多巴胺能神经元损失
Javier Jarazo,Eveline Santos da Silva,Enrico Glaab et al.
Javier Jarazo et al.
COVID-19 is mainly associated with respiratory symptoms, although several reports show that SARS-CoV-2 affects the nervous system. We evaluated the effects of SARS-CoV-2 infection on human derived midbrain organoids by exposing them to the ...
SUMOylation In Cerebral Ischaemia: A Dynamic, Isoform-Specific Regulator of Neuroprotection and Injury [0.03%]
缺血性脑卒中中的SUMO化：神经保护和损伤的动态异构体特异性调节因子
João M Gissoni,Kiara F Campos,Helena L A Vieira et al.
João M Gissoni et al.
Hypoxia-ischaemia and reperfusion (HI/R) damage is a result stemming from any event that interrupts the brain's blood supply, such as the occlusion of a blood vessel. In neurons, the molecular mechanisms involved in the HI/R cascade are div...
Early Surge in Brain GFAP Distribution in Female Hamsters With Mild Peripheral COVID-19 [0.03%]
感染轻度外周COVID-19雌性秋沙鼠的脑部GFAP早期分布增强
Mohammadreza Rahmani Manesh,Leigh E Wicki-Stordeur,Nicole S York et al.
Mohammadreza Rahmani Manesh et al.
Mild to moderate respiratory COVID-19 is commonly associated with a range of neurological symptoms. The two primary proposed mechanisms linking this primarily peripheral disease to the brain, include brain entry of peripheral circulating cy...
Modulation of Murine Hippocampal Synaptic Plasticity by Microbial Metabolites: Sex-Specific Effects of the Short-Chain Fatty Acid Butyrate [0.03%]
肠道微生物代谢产物对小鼠海马区突触可塑性的调节作用：短链脂肪酸丁酸的性别差异效应
Michael K Collins,Cristina Rosell-Cardona,Anna V Golubeva et al.
Michael K Collins et al.
The microbiota-gut-brain-axis is a bidirectional communication system between the trillions of microbes in the gastrointestinal tract and the brain. This axis influences brain processes like learning and memory, but the underlying mechanism...
Effects of a Bacterial Multi-Strain Formulation on Locomotor Sensitization and the Gut Microbiota Structure Induced by Repeated Volatilized Cocaine Exposure in Rats [0.03%]
一种多菌株细菌配方对重复挥发性可卡因暴露诱导的大鼠运动敏感化和肠道微生物群结构的影响
Sara Fabius,Jessika Urbanavicius,Sofía Fernández-Ciganda et al.
Sara Fabius et al.
The gut microbiota (GM), the community of microorganisms inhabiting the gastrointestinal tract, has emerged as a relevant factor in the pathogenesis of substance use disorders (SUD). However, more evidence is required to advance in this fie...
Astrocytes as Histaminergic Gatekeepers of Anxiety: A New Pathway for Emotional Control [0.03%]
星形胶质细胞作为焦虑的组胺门控器：情绪控制的新通路
George J Augustine,Alexei Verkhratsky
George J Augustine
Iker Bengoetxea de Tena,Farhanah Nabilah Sallie,Arvie Rodriguez Abiero et al.
Iker Bengoetxea de Tena et al.
Neuropsychiatric disorders represent a significant global health burden. Despite decades of research, current treatments typically provide only symptomatic relief, rather than addressing the underlying mechanisms of these conditions. Histor...
The Chromatin-Modifying Protein RCOR2/CoREST2 Safeguards Axon-Dendrite Growth and Microtubule Stability in Brain Neurons [0.03%]
染色质修饰蛋白RCOR2/CoREST2通过稳定神经元微管来保障脑源性神经营养因子介导的轴突-树突生长和稳定性
Carlos Wilson,Victoria Rozés-Salvador,José F Drube et al.
Carlos Wilson et al.
Understanding the mechanisms that underlie neuronal dynamics is crucial to promoting brain health. The chromatin-modifying protein RCOR2 (also named CoREST2) has recently gained attention for its neuroprotective roles. Although previous wor...
Exocytosis, Endocytosis, and Replenishment of the Immediately Releasable Pool of Secretory Vesicles. Possible Physiological Relevance in Chromaffin Cells [0.03%]
分泌颗粒的胞外运输、胞内运输和即时可释放池的补充。肾上腺素能细胞中的可能生理相关性
Fernando D Marengo
Fernando D Marengo
In neuroendocrine cells, the fusion of secretory vesicles to the plasma membrane is triggered by a localized increase in cytosolic Ca2+ concentration, which occurs following the activation of voltage-dependent Ca2+ channels. However, there ...