Targeting Brain Cholesterol Homeostasis in Alzheimer's Disease: Mechanisms and Therapeutic Perspectives [0.03%]
针对阿尔茨海默病脑胆固醇稳态的机制及治疗视角
Myuri Ruthirakuhan,Ameer Y Taha,Walter Swardfager
Myuri Ruthirakuhan
Cholesterol is a fundamental component of the central nervous system, supporting myelin integrity, synaptic structure, membrane organization, and neuronal signaling. Because the brain is largely isolated from peripheral cholesterol pools, t...
Effects of Lysine Deacetylation Inhibition Alone or in Combination With Arimoclomol on TDP-43 Proteinopathy [0.03%]
赖氨酸脱乙酰酶抑制剂单独使用或与Arimoclomol联合应用对TDP-43蛋白病的影响
Serena Scozzari,Stefano Fabrizio Columbro,Monica Favagrossa et al.
Serena Scozzari et al.
Cytoplasmic inclusions containing TAR DNA-binding protein 43 kDa (TDP-43) are recognized as a major pathological feature of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Peptidyl-prolyl cis-trans isomerase A (PPIA) intera...
A Biological Framework for Parkinson's Disease: Advances in α-Synuclein-Centered Biomarkers and Staging [0.03%]
帕金森病的生物标志框架：以α-突触核蛋白为中心的生物标志物和分期的新进展
Taku Hatano,Chin-Hsien Lin,Francisco Cardoso
Taku Hatano
Parkinson's disease (PD) is a neurodegenerative disorder marked by substantial heterogeneity in pathological distribution, disease trajectories, and coexisting neuropathologies. Despite this biological complexity, current diagnosis and stag...
Targeting Neuroinflammation in Depression: The Integrative Role of Sigma-1 Receptor Modulation [0.03%]
抑郁症中靶向神经炎症：sigma-1受体调节的整合作用
Jing-Ya Wang,De-Yi Yang,Yun-Feng Li et al.
Jing-Ya Wang et al.
Depression is a leading cause of global disability, yet remains insufficiently treated by conventional monoaminergic antidepressants, which are limited by their delayed onset, variable efficacy, and significant side effects. Accumulating ev...
Enhancing Dopamine Accumulation in Secretory Vesicles of PC12 Cells: Mechanisms, Applications and Limitations [0.03%]
增强PC12细胞分泌囊泡多巴胺蓄积的机制、应用及局限性
Noemi Socas-Pérez,Ricado Borges,José David Machado
Noemi Socas-Pérez
Fifty years ago, Green and Tischler established the chromaffin-derived cell line PC12. This line has been extremely successful to explore many biological functions as PC12 are easily manipulated by molecular biology techniques. These cells ...
Calcium Buffering in Astrocytes and Its Relevance for Experimental Data Interpretation and Computational Modeling [0.03%]
星形胶质细胞中的钙缓冲及其对实验数据解释和计算模型的相关性
Kerstin Lenk,Andre Zeug,Franziska E Müller
Kerstin Lenk
Astrocytic Ca2+ signaling is essential for maintaining physiological brain function, including the modulation of synaptic transmission, neurovascular coupling, and ion homeostasis. However, the spatiotemporal dynamics of astrocytic Ca2+ act...
Brain Bioenergetics in Aging: Neurovascular and Neurometabolic Coupling and Fuels: 15th International Conference on Brain Energy Metabolism [0.03%]
衰老大脑的脑生物能量学：神经血管和神经代谢偶联及燃料分子：第十五届国际脑能量代谢大会
Kelly L Drew,Robert Zorec,Nina Vardjan et al.
Kelly L Drew et al.
This Preface introduces the Special Issue entitled, "Brain Bioenergetics in Aging: Neurovascular and Neurometabolic Coupling and Fuels," which is comprised of manuscripts contributed by invited speakers and program/organizing committee memb...
Energy Stress-Induced Neuroprotection Against Ferroptosis in Dopaminergic Neurons [0.03%]
能量压力介导的神经保护作用抑制多巴胺能神经元铁死亡
Aurélie Jonneaux,William Laine,Patrice Maboudou et al.
Aurélie Jonneaux et al.
Ferroptosis, an iron-dependent form of regulated necrosis, is implicated in the pathogenesis of Parkinson's disease (PD). We studied the influence of energy stress on ferroptosis in differentiated dopaminergic neurons (LUHMES). Glucose depr...
Transcranial Direct Current Stimulation Attenuates Ischemic Stroke-Induced Autonomic and Behavioral Dysfunction via a RAS-Autophagy-Iron Axis in the Brainstem [0.03%]
经颅直流电刺激通过脑干中的RAS-自噬-铁轴减轻缺血性卒中引起的自主神经和行为障碍
Yun Hsu,Chou-Ching Lin,Chih-Hsu Huang et al.
Yun Hsu et al.
Ischemic stroke frequently results in sympathetic overactivity and blood pressure dysregulation, primarily due to impaired central autonomic regulation within the rostral ventrolateral medulla (RVLM) in the brainstem. However, the molecular...
Exercise Increases the Sensitivity of Cerebral Glucose Metabolism to Intranasal Insulin in Young, Healthy Adults [0.03%]
运动提高健康年轻人脑葡萄糖代谢对鼻内胰岛素的敏感性
Jay M J R Carr,Jodie L Koep,Jennifer S Duffy et al.
Jay M J R Carr et al.
Exercise provides a therapeutic pathways to mitigate cognitive decrements through benefits to cerebrovascular and neurological function. Intranasal delivery of insulin also offers a therapeutic pathway, possibly via enhancing cerebral metab...