João Filipe Oliveira,Alfonso Araque
João Filipe Oliveira
Astrocytes, once viewed as passive support cells in the central nervous system, are now recognized as active and dynamic regulators of neural function. Across multiple domains of central nervous system function, astrocytes interact closely ...
Astrocytic Regulation of Aberrant Perineuronal Net Formation in Mecp2-Null Neocortex [0.03%]
Mecp2缺失性新皮层中星形胶质细胞对异常神经外网形成的调节作用
Ashis Sinha,Angelica M Kowalchuk,Nasim Khatibi et al.
Ashis Sinha et al.
Rett syndrome (RTT), caused by mutations in MECP2, is a complex neurological disorder characterized by myriad physiological disruptions, including early closure of the critical period of developmental plasticity and precocious formation of ...
Comparison of Proteomic Analysis of Cerebrospinal Fluid From Neurological Patients With and Without Amyotrophic Lateral Sclerosis [0.03%]
神经病患者脑脊液蛋白组分析比较有无肌萎缩侧索硬化的影响
Eleonora Sabetta,Karin Rallmann,Pille Taba et al.
Eleonora Sabetta et al.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterised by progressive muscle weakness in both bulbar and extremity muscles, leading to a diverse clinical phenotype with motor and non-motor symptoms. Approximately ...
Comparative Study
Journal of neurochemistry. 2026 Jun;170(6):e70508. DOI:10.1111/jnc.70508 2026
Kynurenine Pathway Metabolite Levels in Drug Naïve and Risperidone Treated Schizophrenia: Insights From Systemic and Post-Mortem Brain Tissue Analysis [0.03%]
抗精神病药物利斯培酮治疗的精神分裂症患者犬尿氨酸代谢物水平：来自全身和死后脑组织分析的见解
Joyappa Nikhil,Chinnasamy Thirumoorthy,Priyamvada Sharma et al.
Joyappa Nikhil et al.
Kynurenine pathway (KP), the principal route of tryptophan (TRY) metabolism, is implicated in schizophrenia (SCZ), but findings remain inconsistent, particularly regarding peripheral-central associations and links to immune dysregulation. W...
Sex-Dependent Neurochemical Encoding of Acute Social Experience in Adult CD1 Mice [0.03%]
成人CD1小鼠急性社会经验的性别依赖性神经化学编码
Garikoitz Azkona,Alina Díez-Solinska,Oihane Saez-Atxukarro et al.
Garikoitz Azkona et al.
Acute social interaction rapidly engages physiological and neurochemical systems, yet the extent to which these responses differ between sexes remains incompletely understood. Here, we investigated behavioural, endocrine and region-specific...
Brainstem Astrocytes Regulate Estrus-Dependent Oscillations in Food Intake [0.03%]
脑干星形胶质细胞调节摄食量的周期性波动
K Selin Ozkaya,Ceyda Yalcin,Emily E Haar et al.
K Selin Ozkaya et al.
Previous studies have shown that dorsal vagal complex (DVC) astrocytes play important roles in homeostatic regulation of food intake and caloric balance, specifically upregulation of NMDA receptor-mediated glutamatergic signaling to brainst...
Ischemia-Induced Post-Translational Modifications of GLT-1 Mediate Aberrant Trafficking and Impaired Glutamate Uptake [0.03%]
缺血诱导的GLT-1异常泛素化修饰调控其反常转运及谷氨酸摄取功能受损的机制研究
Simran Kaur Gill,Katelyn Louise Reeb,Max Kroll et al.
Simran Kaur Gill et al.
Glutamate transporters are essential for maintaining CNS homeostasis by clearing extracellular glutamate following synaptic transmission. Dysregulation of these transporters contributes to glutamate-mediated excitotoxicity across numerous n...
The Long Haul: Microtubule Motors as the Essential Supply Line for Neuronal Longevity [0.03%]
长途跋涉：微管马达作为神经元长寿的必需供应链
Emma D Turner,Alison E Twelvetrees
Emma D Turner
The extreme morphology and polarised architecture of neurons require the highly sophisticated microtubule transport system for both construction and lifelong survival. Genomic evidence from an expanding landscape of human mutations supports...
Septins in the Middle-Makers and Breakers of Membrane Contact Sites [0.03%]
Septin：中间人——膜接触位点的缔造者和终结者
TrishaJean J Holt,Elias T Spiliotis
TrishaJean J Holt
Intracellular communication in neurons requires precise coordination of signals across geometrically complex and highly compartmentalized cellular architectures. Membrane contact sites (MCS)-specialized junctions where two organelles are cl...