LRRK2 Mutation Alters Dopamine D2 Receptor Localization in Induced Pluripotent Stem Cells-Derived Astrocytes From Parkinson's Disease Patients: Implications for Neuronal Damage [0.03%]
帕金森病患者诱导多能干细胞来源的星形胶质细胞中LRRK2基因突变改变多巴胺D2受体定位：对神经元损伤的影响
Veronica Mutti,Federica Bono,Zaira Tomasoni et al.
Veronica Mutti et al.
Astrocytes, the most abundant glia subtype, exert a wide range of functions, many of which are essential for maintaining neuronal homeostasis. A variety of neurotransmitter receptors are expressed on astrocytes allowing them to sense extrac...
GM1-Oligosaccharide Rescues Rotenone-Impaired Neuronal Polarization Through RhoA/ROCK Modulation and Mitochondrial Protection [0.03%]
GM1寡糖通过RhoA/ROCK调节和线粒体保护修复罗tenone损伤的神经元极化作用
Pablo E A Rodríguez,Guillermo N Colmano,Andrea Pellegrini et al.
Pablo E A Rodríguez et al.
Neuronal polarization is a fundamental process in the formation of functional neural circuits, relying on the precise coordination between cytoskeletal regulatory signals and mechanisms that sustain cellular integrity. Disruption of these p...
Norepinephrine Couples Astrocytic Metabolism to mTOR-Driven Protein Synthesis [0.03%]
去甲肾上腺素通过 astrocyte 代谢调节mTOR依赖的蛋白质合成
Florencia Cabrera-Cabrera,Helena Tull,Giulia Urone et al.
Florencia Cabrera-Cabrera et al.
Norepinephrine is a neuromodulator that regulates diverse physiological processes in the central nervous system, including astrocytic metabolism. While its metabolic actions in astrocytes are well characterised, its role in regulating prote...
João Filipe Oliveira,Alfonso Araque
João Filipe Oliveira
Astrocytes, once viewed as passive support cells in the central nervous system, are now recognized as active and dynamic regulators of neural function. Across multiple domains of central nervous system function, astrocytes interact closely ...
Astrocytic Regulation of Aberrant Perineuronal Net Formation in Mecp2-Null Neocortex [0.03%]
Mecp2缺失性新皮层中星形胶质细胞对异常神经外网形成的调节作用
Ashis Sinha,Angelica M Kowalchuk,Nasim Khatibi et al.
Ashis Sinha et al.
Rett syndrome (RTT), caused by mutations in MECP2, is a complex neurological disorder characterized by myriad physiological disruptions, including early closure of the critical period of developmental plasticity and precocious formation of ...
Comparison of Proteomic Analysis of Cerebrospinal Fluid From Neurological Patients With and Without Amyotrophic Lateral Sclerosis [0.03%]
神经病患者脑脊液蛋白组分析比较有无肌萎缩侧索硬化的影响
Eleonora Sabetta,Karin Rallmann,Pille Taba et al.
Eleonora Sabetta et al.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterised by progressive muscle weakness in both bulbar and extremity muscles, leading to a diverse clinical phenotype with motor and non-motor symptoms. Approximately ...
Comparative Study
Journal of neurochemistry. 2026 Jun;170(6):e70508. DOI:10.1111/jnc.70508 2026
Kynurenine Pathway Metabolite Levels in Drug Naïve and Risperidone Treated Schizophrenia: Insights From Systemic and Post-Mortem Brain Tissue Analysis [0.03%]
抗精神病药物利斯培酮治疗的精神分裂症患者犬尿氨酸代谢物水平：来自全身和死后脑组织分析的见解
Joyappa Nikhil,Chinnasamy Thirumoorthy,Priyamvada Sharma et al.
Joyappa Nikhil et al.
Kynurenine pathway (KP), the principal route of tryptophan (TRY) metabolism, is implicated in schizophrenia (SCZ), but findings remain inconsistent, particularly regarding peripheral-central associations and links to immune dysregulation. W...
Sex-Dependent Neurochemical Encoding of Acute Social Experience in Adult CD1 Mice [0.03%]
成人CD1小鼠急性社会经验的性别依赖性神经化学编码
Garikoitz Azkona,Alina Díez-Solinska,Oihane Saez-Atxukarro et al.
Garikoitz Azkona et al.
Acute social interaction rapidly engages physiological and neurochemical systems, yet the extent to which these responses differ between sexes remains incompletely understood. Here, we investigated behavioural, endocrine and region-specific...
Brainstem Astrocytes Regulate Estrus-Dependent Oscillations in Food Intake [0.03%]
脑干星形胶质细胞调节摄食量的周期性波动
K Selin Ozkaya,Ceyda Yalcin,Emily E Haar et al.
K Selin Ozkaya et al.
Previous studies have shown that dorsal vagal complex (DVC) astrocytes play important roles in homeostatic regulation of food intake and caloric balance, specifically upregulation of NMDA receptor-mediated glutamatergic signaling to brainst...
Ischemia-Induced Post-Translational Modifications of GLT-1 Mediate Aberrant Trafficking and Impaired Glutamate Uptake [0.03%]
缺血诱导的GLT-1异常泛素化修饰调控其反常转运及谷氨酸摄取功能受损的机制研究
Simran Kaur Gill,Katelyn Louise Reeb,Max Kroll et al.
Simran Kaur Gill et al.
Glutamate transporters are essential for maintaining CNS homeostasis by clearing extracellular glutamate following synaptic transmission. Dysregulation of these transporters contributes to glutamate-mediated excitotoxicity across numerous n...