From Synapses to Circuits, the Role of KIBRA and the WWC Family in Adaptive Brain Function [0.03%]
从突触到回路：KIBRA及WWC家族在适应性脑功能中的作用
Lenora J Volk
Lenora J Volk
KIBRA (WWC1) has been a subject of scientific interest and investigation for almost two decades following its initial association with nonpathological variation in human memory performance. Work in a variety of animal models confirms that K...
Akila Yagoubat,Paul T Conduit
Akila Yagoubat
Microtubules are fundamental to neuronal architecture, providing the structural framework and transport tracks essential for polarisation, compartmentalisation and growth. While the centrosome is the canonical microtubule-organising centre ...
A PARK9 iPSC-Derived Dopaminergic Neuron Model Enables Drug Screening Targeting Autophagy-Lysosome Pathway Dysfunction in Parkinson's Disease [0.03%]
基于iPSC的Parkinson病 PARK9突变多巴胺能神经元模型为自噬-溶酶体通路药物筛选提供新手段
Kei-Ichi Tsukiboshi,Kei-Ichi Ishikawa,Akihiro Yamaguchi et al.
Kei-Ichi Tsukiboshi et al.
Parkinson's disease (PD) is a neurodegenerative disease characterized by dopaminergic neuronal degeneration in the substantia nigra, in which lysosomal dysfunction and impaired autophagy-lysosome pathway activity are increasingly recognized...
Opposing Estrous Cycle-Dependent Norepinephrine and Dopamine Regulation in Response to Methamphetamine [0.03%]
甲基苯丙胺所致交感神经和多巴胺能反应的背腹壳差异性调节及周期依赖性变化
Rohan V Bhimani,Ryan C Pauly,Elizabeth G Mietlicki-Baase et al.
Rohan V Bhimani et al.
The central catecholamine systems, norepinephrine and dopamine, play a critical role in encoding the valence of environmental stimuli to promote engagement in behaviors that potentiate an organism's survival. Furthermore, both neurochemical...
Exercise Snacking in Alzheimer's Disease: A Mechanistic Rationale Based on Repeated Exerkine Signaling [0.03%]
阿尔茨海默病中运动零食的机制依据：基于重复运动因子信号传导
Ricardo A L De Sousa,Joyce Mirlane Moreira Costa,Ramona Ramalho de Souza Pereira et al.
Ricardo A L De Sousa et al.
The Converging Effects of Different Categories of Antidepressants on the Brain: A Systematic Meta-Analysis of Public Transcriptional Profiling Data From the Hippocampus and Cortex [0.03%]
抗抑郁药通过转录调控影响抑郁症患者大脑的机制：来自海马体和大脑皮层公共数据集的系统性元分析研究
Eva M Geoghegan,Megan H Hagenauer,Erin Hernandez et al.
Eva M Geoghegan et al.
Depression can be treated with traditional pharmaceuticals targeting monoaminergic function, nontraditional drug classes and neuromodulatory interventions. To identify mechanisms of action shared across clinically-effective antidepressant t...
Splice Type-Specific Effects of Gαo Subunits on Cerebellar Anatomy and Synapse Formation [0.03%]
Gαo亚型特异性地调控小脑发育和突触形成
Markus Höltje,Anton Wolkowicz,Gudrun Ahnert-Hilger
Markus Höltje
This study investigated the effect of single Gαo1 and Gαo2, as well as double Gαo1/2 knockout on the cerebellar anatomy and synapse formation. The alpha subunit of the G protein Go exists in two splice variants. Knockout of certain Gαo ...
Neurobiological and Behavioral Consequences of Prenatal Methadone or Buprenorphine Exposure: Insight From Animal Models [0.03%]
孕产期接触美沙酮或布桂纳芬对子代神经行为学的影响及动物模型研究进展
Henriette Nyberg,Jannike Mørch Andersen
Henriette Nyberg
The marked increase in opioid use over the past three decades has been accompanied by increased use of medications for opioid use disorder (MOUD), including during pregnancy. However, methadone and buprenorphine, the primary MOUDs, cross th...
Parkinson's Disease Cell Transplantation Therapy: A New Dawn With Pluripotent Stem Cell-Based Therapy [0.03%]
帕金森病细胞移植治疗：基于多能干细胞的新的疗法曙光
Etsuro Nakanishi,Hodaka Yamakado,Nobukatsu Sawamoto et al.
Etsuro Nakanishi et al.
Parkinson's disease (PD), a prevalent neurodegenerative disorder, is characterized by progressive loss of dopaminergic neurons in the midbrain. While dopamine replacement therapy effectively manages early symptoms, its long-term use leads t...
Neural Organoid Models as a Platform for Studying Disease Mechanisms in Amyotrophic Lateral Sclerosis [0.03%]
神经器官模型作为研究肌萎缩侧索硬化症疾病机制的平台
Kristel N Eigenhuis,Roberto Montoro Ferrer,R Jeroen Pasterkamp
Kristel N Eigenhuis
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder affecting upper and lower motor neurons leading to muscle wasting. However, structural and molecular abnormalities, including cortical thinning and TDP-43 pathology, ...