Activation of GCaMP6f-Expressing Chromaffin and Satellite Glial Cells in Murine Adrenal Slices by Nanosecond Electric Pulses [0.03%]
纳秒电脉冲活化小鼠肾上腺切片中GCaMP6f表达的嗜铬细胞和卫星神经胶质细胞
Ciara Viola,Lisha Yang,Vasilii Mansurov et al.
Ciara Viola et al.
Nanosecond electric pulses (NEP) are being explored as a novel bioelectric stimulus to modulate neurosecretion. Recently we reported that NEP trigger transient, voltage-gated Ca2+ channel-mediated Ca2+ influx in cultured murine adrenal chro...
Shiwani Kumari,Roberto Pagano,Katarzyna Orzol et al.
Shiwani Kumari et al.
The mammalian target of rapamycin (mTOR) is a key regulator of neuronal development, metabolism, and plasticity, and its dysregulation is linked to many neurological disorders. Most studies have focused on cytoplasmic mTOR, yet mTOR is also...
Early Hypo-Osmolar Stress Regulates Astrocyte Reactivity After Brain Injury: "New Insights Into Glial Response to Edema" [0.03%]
早期低渗应力调节脑损伤后的星形胶质细胞活化——水肿引起的胶质反应新见解
Camila Vidos,Matías Monteverde Busso,Azul Millán et al.
Camila Vidos et al.
Astrocytes are among the first cellular responders to central nervous system injury, yet the mechanisms governing their earliest responses remain incompletely understood. Here, we investigated astrocyte dynamics during the first hours after...
Understanding Human Cortical Expansion Using Pluripotent Stem Cell-Derived Brain Organoids: Insights Into Progenitor Evolution and Diversity [0.03%]
利用多能干细胞衍生的脑类器官理解人类皮层扩张：祖细胞进化和多样性的新见解
Wendy W Y Choi,Julien Muffat,Yun Li
Wendy W Y Choi
The evolution of the human brain underlies our higher-order cognitive functions. In particular, the cerebral cortex, the outermost layer of the brain, has rapidly evolved to contain a disproportionately large number of neurons relative to t...
Development of a Novel Blood-Based Assay for Brain-Derived Tau and Its Validation in Traumatic Brain Injury [0.03%]
新型脑源性tau蛋白血液检测法的开发及其在创伤性脑损伤中的验证
Wasiu G Balogun,Xuemei Zeng,Michel N Nafash et al.
Wasiu G Balogun et al.
Brain-derived tau (BD-tau) is an emerging blood-based biomarker for neurodegeneration, yet there are currently limited well validated BD-tau assays available for research and clinical use. To enhance access to this vital biomarker for neuro...
Etv5 Is Required for Proper Maturation and Dendritic Development of Adult-Born Granule Cells in the Dentate Gyrus [0.03%]
Etv5对海马齿状回新生颗粒细胞成熟和树突发育的作用不可或缺
Antonella S Ríos,Solana F López,Fernando Federicci et al.
Antonella S Ríos et al.
Adult neurogenesis in the dentate gyrus (DG) of the hippocampus is a dynamic and tightly regulated process that is finely regulated by a diverse array of transcription factors. While the transcription factor Etv5, a member of the Erythrobla...
Preface to the Special Issue: "Molecular and Cellular Mechanisms of Memory" [0.03%]
专刊序言：“记忆的分子和细胞机制”
Clara Ortega-de San Luis,Wayne S Sossin
Clara Ortega-de San Luis
A key question in neuroscience is how memories are formed and maintained at the molecular and cellular levels. Key findings on the importance of transcriptional and translational changes after an experience has occurred have not yet been tr...
Rethinking Alzheimer's Disease Therapy: From Amyloid-Centric Approaches to Multi-Target Phytochemical Strategies [0.03%]
重新思考阿尔茨海默病的治疗：从淀粉样蛋白为中心的方法到多靶点植物化学策略
Emre Aktaş,İlay Yurt,Yağmur Nisa Cerlet et al.
Emre Aktaş et al.
Alzheimer's disease (AD) is the leading cause of dementia, characterized by irreversible neuronal loss and progressive cognitive decline. The disease is driven by complex and interconnected pathological processes, including amyloid-β plaqu...
Caffeine Regulates GABA Transport Homeostasis in the Adolescent Mouse Frontal Cortex via Adenosine A1 Receptor and PKC-Dependent Pathways [0.03%]
咖啡因通过腺苷A1受体和蛋白激酶C依赖通路调节青少年鼠额叶皮质的γ-氨基丁酸转运稳态
Robertta Silva Martins,Vladimir Pedro Peralva Borges-Martins,Carlos Henrique de Carvalho Teixeira et al.
Robertta Silva Martins et al.
Adolescence is a period of several brain changes, making it especially vulnerable to external influences. Abuse of psychoactive drugs, such as caffeine (CAFF), generates changes in cognitive functions. The main pharmacological targets of CA...
PBMC circRNA Profiles Distinguish Atypical From Idiopathic Parkinsonism and Track Clinical Severity Across Syndromes [0.03%]
外周血单个核细胞环状RNA谱型可区分非典型帕金森病与原发性帕金森病并跨疾病综合征地反映临床严重程度
Stylianos Ravanidis,Anastasia Bougea,Fedon-Giasin Kattan et al.
Stylianos Ravanidis et al.
Early separation of atypical Parkinsonian syndromes (APS) from idiopathic Parkinson's disease (iPD) remains challenging. Given that many brain-biased circular RNAs (circRNAs) are stable and expressed in blood cells, peripheral blood mononuc...