Understanding Human Cortical Expansion Using Pluripotent Stem Cell-Derived Brain Organoids: Insights Into Progenitor Evolution and Diversity [0.03%]
利用多能干细胞衍生的脑类器官理解人类皮层扩张：祖细胞进化和多样性的新见解
Wendy W Y Choi,Julien Muffat,Yun Li
Wendy W Y Choi
The evolution of the human brain underlies our higher-order cognitive functions. In particular, the cerebral cortex, the outermost layer of the brain, has rapidly evolved to contain a disproportionately large number of neurons relative to t...
Development of a Novel Blood-Based Assay for Brain-Derived Tau and Its Validation in Traumatic Brain Injury [0.03%]
新型脑源性tau蛋白血液检测法的开发及其在创伤性脑损伤中的验证
Wasiu G Balogun,Xuemei Zeng,Michel N Nafash et al.
Wasiu G Balogun et al.
Brain-derived tau (BD-tau) is an emerging blood-based biomarker for neurodegeneration, yet there are currently limited well validated BD-tau assays available for research and clinical use. To enhance access to this vital biomarker for neuro...
Etv5 Is Required for Proper Maturation and Dendritic Development of Adult-Born Granule Cells in the Dentate Gyrus [0.03%]
Etv5对海马齿状回新生颗粒细胞成熟和树突发育的作用不可或缺
Antonella S Ríos,Solana F López,Fernando Federicci et al.
Antonella S Ríos et al.
Adult neurogenesis in the dentate gyrus (DG) of the hippocampus is a dynamic and tightly regulated process that is finely regulated by a diverse array of transcription factors. While the transcription factor Etv5, a member of the Erythrobla...
Preface to the Special Issue: "Molecular and Cellular Mechanisms of Memory" [0.03%]
专刊序言：“记忆的分子和细胞机制”
Clara Ortega-de San Luis,Wayne S Sossin
Clara Ortega-de San Luis
A key question in neuroscience is how memories are formed and maintained at the molecular and cellular levels. Key findings on the importance of transcriptional and translational changes after an experience has occurred have not yet been tr...
Rethinking Alzheimer's Disease Therapy: From Amyloid-Centric Approaches to Multi-Target Phytochemical Strategies [0.03%]
重新思考阿尔茨海默病的治疗：从淀粉样蛋白为中心的方法到多靶点植物化学策略
Emre Aktaş,İlay Yurt,Yağmur Nisa Cerlet et al.
Emre Aktaş et al.
Alzheimer's disease (AD) is the leading cause of dementia, characterized by irreversible neuronal loss and progressive cognitive decline. The disease is driven by complex and interconnected pathological processes, including amyloid-β plaqu...
Caffeine Regulates GABA Transport Homeostasis in the Adolescent Mouse Frontal Cortex via Adenosine A1 Receptor and PKC-Dependent Pathways [0.03%]
咖啡因通过腺苷A1受体和蛋白激酶C依赖通路调节青少年鼠额叶皮质的γ-氨基丁酸转运稳态
Robertta Silva Martins,Vladimir Pedro Peralva Borges-Martins,Carlos Henrique de Carvalho Teixeira et al.
Robertta Silva Martins et al.
Adolescence is a period of several brain changes, making it especially vulnerable to external influences. Abuse of psychoactive drugs, such as caffeine (CAFF), generates changes in cognitive functions. The main pharmacological targets of CA...
PBMC circRNA Profiles Distinguish Atypical From Idiopathic Parkinsonism and Track Clinical Severity Across Syndromes [0.03%]
外周血单个核细胞环状RNA谱型可区分非典型帕金森病与原发性帕金森病并跨疾病综合征地反映临床严重程度
Stylianos Ravanidis,Anastasia Bougea,Fedon-Giasin Kattan et al.
Stylianos Ravanidis et al.
Early separation of atypical Parkinsonian syndromes (APS) from idiopathic Parkinson's disease (iPD) remains challenging. Given that many brain-biased circular RNAs (circRNAs) are stable and expressed in blood cells, peripheral blood mononuc...
From Synapses to Circuits, the Role of KIBRA and the WWC Family in Adaptive Brain Function [0.03%]
从突触到回路：KIBRA及WWC家族在适应性脑功能中的作用
Lenora J Volk
Lenora J Volk
KIBRA (WWC1) has been a subject of scientific interest and investigation for almost two decades following its initial association with nonpathological variation in human memory performance. Work in a variety of animal models confirms that K...
Akila Yagoubat,Paul T Conduit
Akila Yagoubat
Microtubules are fundamental to neuronal architecture, providing the structural framework and transport tracks essential for polarisation, compartmentalisation and growth. While the centrosome is the canonical microtubule-organising centre ...
A PARK9 iPSC-Derived Dopaminergic Neuron Model Enables Drug Screening Targeting Autophagy-Lysosome Pathway Dysfunction in Parkinson's Disease [0.03%]
基于iPSC的Parkinson病 PARK9突变多巴胺能神经元模型为自噬-溶酶体通路药物筛选提供新手段
Kei-Ichi Tsukiboshi,Kei-Ichi Ishikawa,Akihiro Yamaguchi et al.
Kei-Ichi Tsukiboshi et al.
Parkinson's disease (PD) is a neurodegenerative disease characterized by dopaminergic neuronal degeneration in the substantia nigra, in which lysosomal dysfunction and impaired autophagy-lysosome pathway activity are increasingly recognized...