Astrotactin 2 (ASTN2) regulates emotional and cognitive functions by affecting neuronal morphogenesis and monoaminergic systems [0.03%]
ASTN2通过影响神经元形态发生和单胺能系统调节情感和认知功能
Takahiro Ito,Mikio Yoshida,Tomomi Aida et al.
Takahiro Ito et al.
Astrotactin2 (ASTN2) regulates neuronal migration and synaptic strength through the trafficking and degradation of surface proteins. Deletion of ASTN2 in copy number variants has been identified in patients with schizophrenia, bipolar disor...
Nrf2 is expressed more extensively in neurons than in astrocytes following an acute epileptic seizure in rats [0.03%]
Nrf2在急性癫痫发作后的海马中神经元的表达强于星形胶质细胞
Sereen Sandouka,Aseel Saadi,Rhoda Olowe et al.
Sereen Sandouka et al.
The modulation of the nuclear factor erythroid 2-like 2 (Nrf2) activity has been reported to be implicated in the pathology of various neurological disorders, including epilepsy. Previous studies have demonstrated that Nrf2 is activated in ...
Sleep and memory: The impact of sleep deprivation on transcription, translational control, and protein synthesis in the brain [0.03%]
睡眠与记忆：睡眠剥夺对大脑转录、翻译控制及蛋白质合成的影响
Lisa C Lyons,Yann Vanrobaeys,Ted Abel
Lisa C Lyons
In countries around the world, sleep deprivation represents a widespread problem affecting school-age children, teenagers, and adults. Acute sleep deprivation and more chronic sleep restriction adversely affect individual health, impairing ...
CDGSH iron sulfur domain 2 over-expression alleviates neuronal ferroptosis and brain injury by inhibiting lipid peroxidation via AKT/mTOR pathway following intracerebral hemorrhage in mice [0.03%]
过表达CDGS铁硫域2通过AKT/mTOR途径抑制脂质过氧化来缓解ICH小鼠的神经元铁死亡及脑损伤作用机制研究
Ruihao Li,Xingyu Zhang,Lingui Gu et al.
Ruihao Li et al.
Ferroptosis has been implicated in the pathogenesis of secondary brain injury following intracerebral hemorrhage (ICH), and regulating this process is considered a potential therapy for alleviating further brain injury. A previous study sho...
Mechanistic and therapeutic role of NLRP3 inflammasome in the pathogenesis of Alzheimer's disease [0.03%]
NLRP3炎性小体在阿尔茨海默病发病机制中的作用及治疗潜力
Dhanshree Jha,Erik N T P Bakker,Rahul Kumar
Dhanshree Jha
Alzheimer's disease (AD), a progressive neurodegenerative disorder, has emerged as the most common form of dementia in the elderly. Several pathological hallmarks have been identified, including neuroinflammation. A comprehensive insight in...
Aluminum alters excitability by inhibiting calcium, sodium, and potassium currents in bovine chromaffin cells [0.03%]
铝通过抑制牛肾上腺素髓质细胞的钙、钠和钾电流来改变兴奋性
Andrés M Baraibar,Ricardo de Pascual,Victoria Jiménez Carretero et al.
Andrés M Baraibar et al.
Aluminum (Al3+ ) has long been related to neurotoxicity and neurological diseases. This study aims to describe the specific actions of this metal on cellular excitability and neurotransmitter release in primary culture of bovine chromaffin ...
The β-adrenergic hypothesis of synaptic and microglial impairment in Alzheimer's disease [0.03%]
β肾上腺素能假说在阿尔茨海默病中对突触和小胶质细胞损伤的影响
Shaomin Li
Shaomin Li
Alzheimer's disease (AD) is a progressive neurodegenerative disease originating partly from amyloid β protein-induced synaptic failure. As damaging of noradrenergic neurons in the locus coeruleus (LC) occurs at the prodromal stage of AD, a...
NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro [0.03%]
针对NLRP3的反义寡核苷酸可降低小胶质细胞的免疫活性
Charlotte Braatz,Max P Komes,Kishore Aravind Ravichandran et al.
Charlotte Braatz et al.
Alzheimer's disease (AD) is associated with the cerebral deposition of Amyloid-β (Aβ) peptide, which leads to NLRP3 inflammasome activation and subsequent release of interleukin-1β (IL-1β) and interleukin-18 (IL-18). NLRP3 reduction has...
MED13L and its disease-associated variants influence the dendritic development of cerebral cortical neurons in the mammalian brain [0.03%]
MED13L及其疾病相关变异影响哺乳动物大脑皮层神经元的树突发育
Nanako Hamada,Ikuko Iwamoto,Koh-Ichi Nagata
Nanako Hamada
The mediator complex comprises multiple subcellular subunits that collectively function as a molecular interface between RNA polymerase II and gene-specific transcription factors. Recently, genetic variants to one subunit of the complex, kn...
A single post-exposure oxime RS194B treatment rapidly reactivates acetylcholinesterase and reverses acute symptoms in macaques exposed to diethylphosphorothioate parathion and chlorpyrifos insecticides [0.03%]
一种肟类物质RS194B在接触毒死蜱和氯pyrifos杀虫剂后的单一暴露后处理可快速重新激活乙酰胆碱酯酶并逆转食蟹猴的急性症状
Yvonne J Rosenberg,Kelly Garcia,Justin Diener et al.
Yvonne J Rosenberg et al.
Millions of individuals globally suffer from inadvertent, occupational or self-harm exposures from organophosphate (OP) insecticides, significantly impacting human health. Similar to nerve agents, insecticides are neurotoxins that target an...