Lipid metabolism in dopaminergic neurons influences light entrainment [0.03%]
多巴胺能神经元中的脂质代谢影响生物钟的光校准作用
Regina F Fernandez,Emily S Wilson,Victoria Diaz et al.
Regina F Fernandez et al.
Dietary lipids, particularly omega-3 polyunsaturated fatty acids, are speculated to impact behaviors linked to the dopaminergic system, such as movement and control of circadian rhythms. However, the ability to draw a direct link between do...
Nimodipine accelerates the restoration of functional hyperemia during spreading oligemia [0.03%]
尼莫地平加速散在性低灌注期间功能性高灌注的恢复
Ákos Menyhárt,Armand Rafael Bálint,Péter Kozák et al.
Ákos Menyhárt et al.
Spreading depolarization (SD) is assumed to be the pathophysiological correlate of migraine aura, leading to spreading depression of activity and a long-lasting vasoconstriction known as spreading oligemia. Furthermore, cerebrovascular reac...
Coupling between GPR143 and dopamine D2 receptor is required for selective potentiation of dopamine D2 receptor function by L-3,4-dihydroxyphenylalanine in the dorsal striatum [0.03%]
多巴胺D2受体与GPR143偶联对于左旋多巴在背侧纹状体中选择性增强多巴胺D2受体的功能是必需的
Daiki Masukawa,Satoshi Kitamura,Rei Tajika et al.
Daiki Masukawa et al.
Dopamine (DA) is involved in neurological and physiological functions such as motor control. L-3,4-dihydroxyphenylalanine (L-DOPA), a precursor of DA, is conventionally believed to be an inert amino acid precursor of DA, and its major thera...
Astrotactin 2 (ASTN2) regulates emotional and cognitive functions by affecting neuronal morphogenesis and monoaminergic systems [0.03%]
ASTN2通过影响神经元形态发生和单胺能系统调节情感和认知功能
Takahiro Ito,Mikio Yoshida,Tomomi Aida et al.
Takahiro Ito et al.
Astrotactin2 (ASTN2) regulates neuronal migration and synaptic strength through the trafficking and degradation of surface proteins. Deletion of ASTN2 in copy number variants has been identified in patients with schizophrenia, bipolar disor...
Nrf2 is expressed more extensively in neurons than in astrocytes following an acute epileptic seizure in rats [0.03%]
Nrf2在急性癫痫发作后的海马中神经元的表达强于星形胶质细胞
Sereen Sandouka,Aseel Saadi,Rhoda Olowe et al.
Sereen Sandouka et al.
The modulation of the nuclear factor erythroid 2-like 2 (Nrf2) activity has been reported to be implicated in the pathology of various neurological disorders, including epilepsy. Previous studies have demonstrated that Nrf2 is activated in ...
Sleep and memory: The impact of sleep deprivation on transcription, translational control, and protein synthesis in the brain [0.03%]
睡眠与记忆：睡眠剥夺对大脑转录、翻译控制及蛋白质合成的影响
Lisa C Lyons,Yann Vanrobaeys,Ted Abel
Lisa C Lyons
In countries around the world, sleep deprivation represents a widespread problem affecting school-age children, teenagers, and adults. Acute sleep deprivation and more chronic sleep restriction adversely affect individual health, impairing ...
CDGSH iron sulfur domain 2 over-expression alleviates neuronal ferroptosis and brain injury by inhibiting lipid peroxidation via AKT/mTOR pathway following intracerebral hemorrhage in mice [0.03%]
过表达CDGS铁硫域2通过AKT/mTOR途径抑制脂质过氧化来缓解ICH小鼠的神经元铁死亡及脑损伤作用机制研究
Ruihao Li,Xingyu Zhang,Lingui Gu et al.
Ruihao Li et al.
Ferroptosis has been implicated in the pathogenesis of secondary brain injury following intracerebral hemorrhage (ICH), and regulating this process is considered a potential therapy for alleviating further brain injury. A previous study sho...
Mechanistic and therapeutic role of NLRP3 inflammasome in the pathogenesis of Alzheimer's disease [0.03%]
NLRP3炎性小体在阿尔茨海默病发病机制中的作用及治疗潜力
Dhanshree Jha,Erik N T P Bakker,Rahul Kumar
Dhanshree Jha
Alzheimer's disease (AD), a progressive neurodegenerative disorder, has emerged as the most common form of dementia in the elderly. Several pathological hallmarks have been identified, including neuroinflammation. A comprehensive insight in...
Aluminum alters excitability by inhibiting calcium, sodium, and potassium currents in bovine chromaffin cells [0.03%]
铝通过抑制牛肾上腺素髓质细胞的钙、钠和钾电流来改变兴奋性
Andrés M Baraibar,Ricardo de Pascual,Victoria Jiménez Carretero et al.
Andrés M Baraibar et al.
Aluminum (Al3+ ) has long been related to neurotoxicity and neurological diseases. This study aims to describe the specific actions of this metal on cellular excitability and neurotransmitter release in primary culture of bovine chromaffin ...
The β-adrenergic hypothesis of synaptic and microglial impairment in Alzheimer's disease [0.03%]
β肾上腺素能假说在阿尔茨海默病中对突触和小胶质细胞损伤的影响
Shaomin Li
Shaomin Li
Alzheimer's disease (AD) is a progressive neurodegenerative disease originating partly from amyloid β protein-induced synaptic failure. As damaging of noradrenergic neurons in the locus coeruleus (LC) occurs at the prodromal stage of AD, a...