E3 Ubiquitin Ligase Nedd4-2 Exacerbates Seizure-Induced Mitochondrial Defects in an Alzheimer's Disease Mouse Model [0.03%]
E3泛素连接酶Nedd4-2加重阿尔茨海默病小鼠模型中癫痫引起的线粒体缺陷
Yingxin Wang,Jiuhe Zhu,Simon Lizarazo et al.
Yingxin Wang et al.
Seizure is one of the common comorbidities in Alzheimer's disease (AD). Seizures in AD have been shown to occur more often with early-onset disease, particularly when there is a familial presenilin I (PS1) mutation or abnormal expression of...
Simultaneous Expression of Sigma-1 Receptor and Tetraspanins Highlights Pathways of Receptor Sorting Into Extracellular Vesicles [0.03%]
σ-1受体与四跨膜蛋白的同时表达揭示了受体分选进入细胞外囊泡的途径
Edijs Vavers,Sergei Kopanchuk,Santa Veiksina et al.
Edijs Vavers et al.
Sigma-1 receptor (Sig1R) is an endoplasmic reticulum (ER) chaperone protein involved in regulating ER function, cellular stress responses, and autophagy, and disturbed Sig1R function has been associated with neurodegenerative and neuropsych...
The Role of Loss-of-Function KCNH2 Variants in Cardiac Arrhythmias, Seizures and the Risk of Sudden Unexpected Death in Epilepsy [0.03%]
KCNH2失活变异在心律失常、癫痫发作及癫痫猝死风险中的作用
Hian M Lee,Xue N Gan,Khaing Phyu Aung et al.
Hian M Lee et al.
Sudden Unexpected Death in Epilepsy (SUDEP) is the leading cause of mortality in patients in epilepsy, yet its underlying mechanisms are poorly understood. Emerging evidence suggests a significant role for genetic factors that influence car...
When Pathways Converge: Iron, Lipid Peroxidation, and α-Synuclein in Ferroptosis-Driven Dopaminergic Neurodegeneration [0.03%]
当途径汇聚时：铁、脂质过氧化与α-突触核蛋白在铁死亡驱动的多巴胺能神经元退行性变中的作用
Carmem L Sperlich,Brent R Stockwell,Marcelo Farina
Carmem L Sperlich
The selective degeneration of dopaminergic neurons is a hallmark of Parkinson's disease and related disorders. While multiple cell death pathways have been implicated, ferroptosis has recently emerged as a critical mechanism. This iron-depe...
Early Effects of Poly(I:C)-induced Neuroinflammation on Hippocampal Astrocyte Function and Glycolytic Metabolism [0.03%]
聚肌胞诱导的神经炎症对海马星形胶质细胞功能和糖酵解代谢早期影响的效果研究
Adriana Fernanda K Vizuete,João Pedro Montandon Garcez,Maria Cristina M Pellenz et al.
Adriana Fernanda K Vizuete et al.
Concern is growing about the role of neurotropic viruses, such as Zika virus, West Nile virus, herpes simplex virus, SARS-CoV-2, and human immunodeficiency virus, in central nervous system (CNS) infections, which trigger host immune respons...
Correction to "Astrocyte Bioenergetic Remodeling as a Central Trait of Disrupted Glucocorticoid Signaling: Mechanisms and Implications for Stress Vulnerability" [0.03%]
“胶质细胞生物能量重塑是糖皮质激素信号受损的核心特征：机制及其对压力易感性的意义”的勘误通知书
Published Erratum
Journal of neurochemistry. 2026 Apr;170(4):e70439. DOI:10.1111/jnc.70439 2026
ATG14-Mediated SNARE Complex Activation Promotes ΔFosB Degradation to Ameliorate Levodopa-Induced Dyskinesia [0.03%]
ATG14介导的SNARE复合物活化促进ΔFosB降解以缓解左旋多巴引起的异动症
Yi Wu,Ke Liu,Zhaoyuan Zhang et al.
Yi Wu et al.
The chronic accumulation of ΔFosB in striatal medium spiny neurons has been implicated as a pivotal contributor to the pathogenesis of levodopa-induced dyskinesia (LID). While recent studies have implicated autophagy in the degradation of ...
Targeting Glutamate Excitotoxicity With Memantine Modulates Glial Response and Protects Motoneurons After Spinal Root Lesion [0.03%]
用美金刚酸作用谷氨酸兴奋毒性以调节胶质细胞反应和脊神经根损伤后的运动神经元保护作用
Arthur Ventura Martins Leão,Gabriel Gaspar Bíscaro,Alexandre Leite Rodrigues de Olivera et al.
Arthur Ventura Martins Leão et al.
Spinal root injuries trigger longitudinal spinal cord damage, leading to motoneuron degeneration, gliosis, and synaptic loss. Glutamate excitotoxicity through NMDA and AMPA receptor overstimulation is a key driver of this pathology, highlig...
Clinical Evaluation of Three KRS Families and Cellular Analysis of Distinct ATP13A2 Mutations Reveal Different Levels of Iron Accumulation [0.03%]
三个KRS家系的临床评价及ATP13A2不同突变的细胞分析揭示了不同的铁蓄积水平
Ezgi Erterek,Benan Temizci,Şeyma Tekgül et al.
Ezgi Erterek et al.
Kufor-Rakeb Syndrome (KRS) is a rare neurodegenerative disease caused by homozygous mutations in the ATP13A2 gene. The ATP13A2 protein, found in lysosomal and late-endosomal membranes, performs cellular functions such as iron-chelating agen...
L-Leucine Upregulates Lysosomal Biogenesis and Autophagy to Lower Plaques in 5XFAD Mouse Model of Alzheimer's Disease [0.03%]
L-亮氨酸通过上调自噬小体生物合成和自噬作用来降低5XFAD阿尔茨海默病小鼠模型中的斑块形成
Ramesh K Paidi,Sukhamoy Gorai,Susanta Mondal et al.
Ramesh K Paidi et al.
Twenty different amino acids are required for the human body for proper functioning as amino acids serve as building blocks for proteins. We screened different essential and non-essential amino acids for the ability to stimulate lysosomal b...