A Comprehensive Characterization of the Phospholipid and Cholesterol Composition of the Uncinate Fasciculus in the Human Brain: Evidence of Age-Related Alterations [0.03%]
人脑钩束磷脂和胆固醇组成的特点及年龄相关变化的证据
Kelly Perlman,Chuck T Chen,Mackenzie E Smith et al.
Kelly Perlman et al.
The uncinate fasciculus (UF) is a long-range association fiber tract connecting the anterior temporal lobe with the orbitofrontal cortex and has been linked to a multitude of physiological and pathophysiological conditions such as aging, ep...
Schwann Cells in Development, Regeneration, and Therapeutic Applications: Insights From the Sciatic Nerve Model [0.03%]
雪旺细胞在发育、再生和治疗应用中的作用：来自坐骨神经模型的见解
Vanina Usach,Paula A Soto,C Patricia Setton-Avruj
Vanina Usach
The sciatic nerve is the largest nerve in the human body and is frequently affected by lesions, causing pain and even loss of sensitivity. The sciatic nerve injury model provides a robust platform to study the degeneration-regeneration proc...
Peri-Microvascular Glycogen and Lactate Regulate Capillary Constrictions and Ischemia Outcome in Mice [0.03%]
小鼠周围微血管糖原和乳酸调节毛细血管收缩及缺血结局
Gokhan Uruk,Buket Donmez-Demir,Sinem Yilmaz-Ozcan et al.
Gokhan Uruk et al.
Ischemic stroke results in sudden blood flow cessation, thus unmet energy requirements. Glycogen stored around peri-microvascular astrocyte end-feet may mediate capillary contractility and cerebral blood flow alterations. Under glucose-depr...
E3 Ubiquitin Ligase Nedd4-2 Exacerbates Seizure-Induced Mitochondrial Defects in an Alzheimer's Disease Mouse Model [0.03%]
E3泛素连接酶Nedd4-2加重阿尔茨海默病小鼠模型中癫痫引起的线粒体缺陷
Yingxin Wang,Jiuhe Zhu,Simon Lizarazo et al.
Yingxin Wang et al.
Seizure is one of the common comorbidities in Alzheimer's disease (AD). Seizures in AD have been shown to occur more often with early-onset disease, particularly when there is a familial presenilin I (PS1) mutation or abnormal expression of...
Simultaneous Expression of Sigma-1 Receptor and Tetraspanins Highlights Pathways of Receptor Sorting Into Extracellular Vesicles [0.03%]
σ-1受体与四跨膜蛋白的同时表达揭示了受体分选进入细胞外囊泡的途径
Edijs Vavers,Sergei Kopanchuk,Santa Veiksina et al.
Edijs Vavers et al.
Sigma-1 receptor (Sig1R) is an endoplasmic reticulum (ER) chaperone protein involved in regulating ER function, cellular stress responses, and autophagy, and disturbed Sig1R function has been associated with neurodegenerative and neuropsych...
The Role of Loss-of-Function KCNH2 Variants in Cardiac Arrhythmias, Seizures and the Risk of Sudden Unexpected Death in Epilepsy [0.03%]
KCNH2失活变异在心律失常、癫痫发作及癫痫猝死风险中的作用
Hian M Lee,Xue N Gan,Khaing Phyu Aung et al.
Hian M Lee et al.
Sudden Unexpected Death in Epilepsy (SUDEP) is the leading cause of mortality in patients in epilepsy, yet its underlying mechanisms are poorly understood. Emerging evidence suggests a significant role for genetic factors that influence car...
When Pathways Converge: Iron, Lipid Peroxidation, and α-Synuclein in Ferroptosis-Driven Dopaminergic Neurodegeneration [0.03%]
当途径汇聚时：铁、脂质过氧化与α-突触核蛋白在铁死亡驱动的多巴胺能神经元退行性变中的作用
Carmem L Sperlich,Brent R Stockwell,Marcelo Farina
Carmem L Sperlich
The selective degeneration of dopaminergic neurons is a hallmark of Parkinson's disease and related disorders. While multiple cell death pathways have been implicated, ferroptosis has recently emerged as a critical mechanism. This iron-depe...
Early Effects of Poly(I:C)-induced Neuroinflammation on Hippocampal Astrocyte Function and Glycolytic Metabolism [0.03%]
聚肌胞诱导的神经炎症对海马星形胶质细胞功能和糖酵解代谢早期影响的效果研究
Adriana Fernanda K Vizuete,João Pedro Montandon Garcez,Maria Cristina M Pellenz et al.
Adriana Fernanda K Vizuete et al.
Concern is growing about the role of neurotropic viruses, such as Zika virus, West Nile virus, herpes simplex virus, SARS-CoV-2, and human immunodeficiency virus, in central nervous system (CNS) infections, which trigger host immune respons...
Correction to "Astrocyte Bioenergetic Remodeling as a Central Trait of Disrupted Glucocorticoid Signaling: Mechanisms and Implications for Stress Vulnerability" [0.03%]
“胶质细胞生物能量重塑是糖皮质激素信号受损的核心特征：机制及其对压力易感性的意义”的勘误通知书
Published Erratum
Journal of neurochemistry. 2026 Apr;170(4):e70439. DOI:10.1111/jnc.70439 2026
ATG14-Mediated SNARE Complex Activation Promotes ΔFosB Degradation to Ameliorate Levodopa-Induced Dyskinesia [0.03%]
ATG14介导的SNARE复合物活化促进ΔFosB降解以缓解左旋多巴引起的异动症
Yi Wu,Ke Liu,Zhaoyuan Zhang et al.
Yi Wu et al.
The chronic accumulation of ΔFosB in striatal medium spiny neurons has been implicated as a pivotal contributor to the pathogenesis of levodopa-induced dyskinesia (LID). While recent studies have implicated autophagy in the degradation of ...