Transcriptomic analysis of PADI4 target genes during multi-lineage differentiation of embryonic stem cells [0.03%]
胚胎干细胞多系分化过程中PADI4靶基因的转录组分析
Anup Kumar Singh,Soumen Khan,Daniel Moore et al.
Anup Kumar Singh et al.
During mammalian embryo development, pluripotent epiblast cells diversify into the three primary germ layers, which will later give rise to all fetal and adult tissues. These processes involve profound transcriptional and epigenetic changes...
Neutrophil attachment via Mac-1 (αMβ2; CD11b/CD18; CR3) integrins induces PAD4 deimination of profilin and histone H3 [0.03%]
中性粒细胞通过Mac-1（αMβ2；CD11b / CD18；CR3）整联蛋白诱导PAD4对profilin和组蛋白H3的脱氨基作用
Indira Neeli,Maryam Moarefian,Jayalakshmi Kuseladass et al.
Indira Neeli et al.
Neutrophil adhesion to endothelia, entry into tissues and chemotaxis constitute essential steps in the immune response to infections that drive inflammation. Neutrophils bind to other cells and migrate via adhesion receptors, notably the α...
Citrulline is not a major determinant of autoantibody reactivity to neutrophil extracellular traps [0.03%]
瓜氨酸不是中性粒细胞胞外陷阱自身抗体反应的主要决定因素
Cynthia de Bont,Ger J M Pruijn
Cynthia de Bont
One of the main strategies of neutrophils in responding to microbial infections is the formation of neutrophil extracellular traps (NETs). NETs are web-like structures of decondensed chromatin associated with antimicrobial proteins. Citrull...
Mohammad Aslam Saifi,I-Cheng Ho
Mohammad Aslam Saifi
Proteins once translated are subjected to post-translational modifications (PTMs) that can critically modify their characteristics. Citrullination is a unique type of PTM that is catalysed by peptidylarginine deiminase (PAD) enzymes, which ...
Neutrophil peptidylarginine deiminase 4 is essential for detrimental age-related cardiac remodelling and dysfunction in mice [0.03%]
小鼠有害的年龄相关性心脏重塑和功能障碍需要中性粒细胞肽精氨idine脱亚胺酶4的作用
Stijn Van Bruggen,Sirima Kraisin,Jore Van Wauwe et al.
Stijn Van Bruggen et al.
Mice fully deficient in peptidylarginine deiminase 4 (PAD4) enzyme have preserved cardiac function and reduced collagen deposition during ageing. The cellular source of PAD4 is hypothesized to be neutrophils, likely due to PAD4's involvemen...
Citrullination and the protein code: crosstalk between post-translational modifications in cancer [0.03%]
瓜氨酸化与蛋白质密码：癌症中翻译后修饰的相互作用
Koyo Harada,Simon M Carr,Amit Shrestha et al.
Koyo Harada et al.
Post-translational modifications (PTMs) of proteins are central to epigenetic regulation and cellular signalling, playing an important role in the pathogenesis and progression of numerous diseases. Growing evidence indicates that protein ar...
Maria A Christophorou,Priyanka Sharma,Xuesen Zhang
Maria A Christophorou
Inhibiting MEK1 R189 citrullination enhances the chemosensitivity of docetaxel to multiple tumour cells [0.03%]
抑制MEK1 R189瓜氨酸化可增强-docetaxel对多种肿瘤细胞的化疗敏感性
Teng Xue,Shujia Fei,Jian Gu et al.
Teng Xue et al.
Drug resistance is still a big challenge for cancer patients. We previously demonstrated that inhibiting peptidylarginine deiminase 2 (PADI2) enzyme activity with Cl-amine increases the efficacy of docetaxel (Doc) on tamoxifen-resistant bre...
An unbiased proteomic analysis of PAD4 in human monocytes: novel substrates, binding partners and subcellular localizations [0.03%]
人单核细胞中PAD4无偏见蛋白质组分析：新型底物、结合蛋白及亚细胞定位
Mekha A Thomas,Seok-Young Kim,Ashley M Curran et al.
Mekha A Thomas et al.
Peptidylarginine deiminase IV (PAD4) post-translationally converts arginine residues in proteins to citrullines and is implicated in playing a central role in the pathogenesis of several diseases. Although PAD4 was historically thought to b...
Marie-Claire Méchin,Michel Simon
Marie-Claire Méchin
Peptidylarginine deiminases (PADs) transform a protein arginine residue into the non-standard amino acid citrulline. This calcium-dependent post-translational modification of proteins is called citrullination or deimination. As described in...