Ricard Solé,Christopher Kempes,Susan Stepney
Ricard Solé
The questions of how life forms, whether life is an inevitable outcome and how diverse its presentation could be remain some of the most profound in science. Investigations into the origin of life confront key issues such as uncovering key ...
Pablo Carbonell,Juli Peretó
Pablo Carbonell
The transition from geochemistry to biochemistry marks a fundamental event in the emergence of life. Recent advancements in computational methods and systems chemistry offer new insights into how primitive biochemical systems evolved. While...
Science of the gaps [0.03%]
科学的空白原理
Eric Smith,Alicja Kubica
Eric Smith
We consider the problem of evaluating and expanding upon speculative hypotheses about the origin of life. The combination of life's complexity and its potential for historical contingency makes missing knowledge and missing ideas, which we ...
Maud Hofmann,Farouk Abdo,Olivier Borkowski et al.
Maud Hofmann et al.
The current form of life on Earth is the outcome of a series of biochemical events that led to the formation of early life with a specific molecular composition encoding its many functions. However, other trajectories of events with widely ...
Kristoffer Reinholt Thomsen,Artemy Kolchinsky,Steen Rasmussen
Kristoffer Reinholt Thomsen
An integrated protocellular system is presented and studied in simulation. In this system, co-factor molecules serve both as part of an electron relay for an energy transduction mechanism and as combinatorial molecules that can replicate. T...
Stuart Kauffman,Andrea Roli
Stuart Kauffman
We present an integrated and testable theory for the spontaneous emergence of life up to the prokaryote with template replication and coding. Collectively autocatalytic small-molecule sets, DNA sets, RNA sets and peptide sets have been disc...
Ricard Solé,Manlio De Domenico
Ricard Solé
The path towards the emergence of life in our biosphere involved several key events allowing for the persistence, reproduction and evolution of molecular systems. All these processes took place in a given environmental context and required ...
Can the origin of biosynthetic routes be explained by a Frankenstein's monster-like spontaneous assembly of prebiotic reactants? [0.03%]
生命合成途径的起源能像弗兰肯斯坦 Monster 一样由前生命底物随机拼凑而成吗？
Alicia Negrón-Mendoza,Ricardo Hernández-Morales,Antonio Lazcano
Alicia Negrón-Mendoza
Since it is easy to envision that prebiotically synthesized molecules underwent reactions comparable or even identical to those that occur in some metabolic pathways, it has been argued that biosynthetic routes emerged from the direct assem...
Generalizing the central dogma as a cross-hierarchical principle of biology [0.03%]
将中心法则作为生物学跨层次原则的通用理论模型
Nobuto Takeuchi,Kunihiko Kaneko
Nobuto Takeuchi
The central dogma of molecular biology, as originally proposed by Crick, asserts that information passed into protein cannot flow back out. This principle has been interpreted as underpinning modern understandings of heredity and evolution,...
How hard is it to encapsulate life? The general constraints on encapsulation [0.03%]
囊括一切的生命很难吗？关于生命的基本限制条件
Christopher P Kempes,Diana Avila,Cole Mathis
Christopher P Kempes
Many studies of the origins of life focus on the advantages of encapsulation. Independent of these advantages, there may be serious challenges to overcome for a system to become encapsulated. Here, we address the general constraints associa...