Contributions of transcriptional noise to leukaemia evolution: KAT2A as a case-study [0.03%]
转录噪声对白血病进化的影响：以KAT2A为例的研究
Cristina Pina
Cristina Pina
Transcriptional noise is proposed to participate in cell fate changes, but contributions to mammalian cell differentiation systems, including cancer, remain associative. Cancer evolution is driven by genetic variability, with modulatory or ...
Choice of friction coefficient deeply affects tissue behaviour in stochastic epithelial vertex models [0.03%]
摩擦系数的选择深入影响上皮顶点模型中的组织行为
Pilar Guerrero,Ruben Perez-Carrasco
Pilar Guerrero
To understand the mechanisms that coordinate the formation of biological tissues, the use of numerical implementations is necessary. The complexity of such models involves many assumptions and parameter choices that result in unpredictable ...
Dagan Jenkins,Jonathan R Chubb,Gabriel Galea
Dagan Jenkins
Andrew E Teschendorff
Andrew E Teschendorff
Epigenetic changes are known to accrue in normal cells as a result of ageing and cumulative exposure to cancer risk factors. Increasing evidence points towards age-related epigenetic changes being acquired in a quasi-stochastic manner, and ...
How do stochastic processes and genetic threshold effects explain incomplete penetrance and inform causal disease mechanisms? [0.03%]
随机过程和遗传阈值效应如何解释不完全外显并提供因果疾病机制的信息？
Dagan Jenkins
Dagan Jenkins
Incomplete penetrance is the rule rather than the exception in Mendelian disease. In syndromic monogenic disorders, phenotypic variability can be viewed as the combination of incomplete penetrance for each of multiple independent clinical f...
Veronica van Heyningen
Veronica van Heyningen
Development from fertilized egg to functioning multi-cellular organism requires precision. There is no precision, and often no survival, without plasticity. Plasticity is conferred partly by stochastic variation, present inherently in all b...
Transcriptional priming and chromatin regulation during stochastic cell fate specification [0.03%]
随机细胞命运决定过程中转录起始与染色质调控
Alison J Ordway,Rina N Helt,Robert J Johnston Jr
Alison J Ordway
Stochastic cell fate specification, in which a cell chooses between two or more fates with a set probability, diversifies cell subtypes in development. Although this is a vital process across species, a common mechanism for these cell fate ...
A dynamical perspective: moving towards mechanism in single-cell transcriptomics [0.03%]
动态视角：单细胞转录组学机制研究中的运动趋势
Rory J Maizels
Rory J Maizels
As the field of single-cell transcriptomics matures, research is shifting focus from phenomenological descriptions of cellular phenotypes to a mechanistic understanding of the gene regulation underneath. This perspective considers the value...
Bet-hedging and variability in plant development: seed germination and beyond [0.03%]
植物发育中的保险性多样化和变异性：种子萌发及其他方面
Katie Abley,Rituparna Goswami,James C W Locke
Katie Abley
When future conditions are unpredictable, bet-hedging strategies can be advantageous. This can involve isogenic individuals producing different phenotypes, under the same environmental conditions. Ecological studies provide evidence that va...
Lysosomal storage, impaired autophagy and innate immunity in Gaucher and Parkinson's diseases: insights for drug discovery [0.03%]
溶酶体贮存，自噬受阻及固有免疫在戈谢氏症和帕金森症中的作用：为新药研发提供的启示
Alexander Hull,Magda L Atilano,Laith Gergi et al.
Alexander Hull et al.
Impairment of autophagic-lysosomal pathways is increasingly being implicated in Parkinson's disease (PD). GBA1 mutations cause the lysosomal storage disorder Gaucher disease (GD) and are the commonest known genetic risk factor for PD. GBA1 ...