Lorna G Moore
Lorna G Moore
Pregnancy encompasses the portion of the life cycle subjected to among the strongest of evolutionary pressures owing to the nature of mammalian reproduction and the characteristics of the human species. The pioneering work of early investig...
The uteroplacental circulation at high altitude: adaptation and maladaptation [0.03%]
高海拔地区的胎盘循环：适应与不适应
Xiang-Qun Hu,Chiranjib Dasgupta,Yu Gao et al.
Xiang-Qun Hu et al.
The greatest challenge of living at high altitude is hypoxia. Hypoxia imposes immense impacts on reproduction. Gestation at high altitude is associated with high incidence of fetal growth restriction (FGR) and pre-eclampsia owing to maladap...
Altitude and risk of pre-eclampsia: insights from a large-scale epidemiological study in Ecuador [0.03%]
海拔与子痫前期风险的关系：来自厄瓜多尔一项大规模流行病学研究的启示
Emma Mitchell-Sparke,Bart Theeuwes,Imogen Grant et al.
Emma Mitchell-Sparke et al.
Exposure to hypobaric hypoxia at high altitude is associated with adverse pregnancy outcomes, including low birth weight and stillbirth. However, the relationship between high altitude and pre-eclampsia remains less well defined, with confl...
Placental mitochondria in high-altitude pregnancy: metabolic adaptations and a toolkit for respiratory assessment [0.03%]
高海拔妊娠中的胎盘线粒体：代谢适应与呼吸功能评估工具包
Andrew Murray,Jenna Armstrong,Katie O&#x;Brien
Andrew Murray
Ascent to high altitude is accompanied by physiological responses that, to an extent, mitigate the challenge of hypobaric hypoxia, maintaining arterial oxygen content and convective oxygen delivery. Nevertheless, arterial oxygen tension (pO...
Fetal nutrient flux and oxidative metabolism during hypoxia: adaptive responses to defend fetal growth [0.03%]
胎儿低氧时机体营养物质转运和氧化代谢：适应性反应以维持胎儿生长发育
Hannah M Kyllo,Stephanie R Wesolowski
Hannah M Kyllo
Fetal oxidative metabolism, the primary determinant of growth, depends on oxygen and nutrient supply. Fetuses with fetal growth restriction (FGR) are exposed to hypoxia and an altered nutrient milieu. Here, we examine hypoxia-associated met...
High-altitude pregnancy adaptation: evidence from a Himalayan population in Leh [0.03%]
高原妊娠适应性：喜马拉雅地区莱赫人群的证据
Sara L Hillman,Padma Dolma
Sara L Hillman
Leh, Ladakh, is situated at an altitude of more than 3500 metres above sea level (masl) and serves as a natural hypoxic environment for studying the effects of a low-oxygen environment on pregnancy. Over a 10 year collaboration, pregnant wo...
Dino A Giussani
Dino A Giussani
High-altitude pregnancy lowers birth weight, and highland ancestry protects against this. Mechanisms mediating both effects are of interest, and alterations in uterine blood flow and placental metabolism have been implicated. However, this ...
Graham J Burton,Lorna G Moore,Dino A Giussani et al.
Graham J Burton et al.
Maternal body mass index is related to fetal uptake of glucose and oxygen via fetal insulin resistance rather than fetal glucose levels [0.03%]
母体体质指数与胎儿胰岛素抵抗有关，而非与胎儿葡萄糖水平有关，这关系到胎儿对葡萄糖和氧气的吸收量
Trond Melbye Michelsen,Muhammad Umar Sajjad,Guttorm Haugen et al.
Trond Melbye Michelsen et al.
Maternal obesity significantly impacts fetal growth and is linked to adverse pregnancy outcomes. However, the specific influence of maternal metabolic status on fetal metabolism and growth in healthy pregnancies is poorly understood. This s...
Anna Papafragou,Myrto Grigoroglou
Anna Papafragou
A foundational assumption in theoretical models of communication is that the derivation of pragmatic meaning involves the calculation of speaker intention and hence relies on a form of Theory of Mind (ToM). Recent theorizing, however, has c...