Gene co-occurrence and its association with phage infectivity in bacterial pangenomes [0.03%]
细菌基因组中的基因共发生及其与噬菌体感染性的关联
Anne Kupczok,Athina Gavriilidou,Emilian Paulitz et al.
Anne Kupczok et al.
Phages infect bacteria and have recently re-emerged as a promising strategy to combat bacterial infections. However, there is a lack of methods to predict whether and why a particular phage can or cannot infect a bacterial strain based on t...
Abiotic environmental conditions determine phage resistance outcomes in a salt-marsh bacterium [0.03%]
盐沼细菌的噬菌体抗性受非生物环境条件决定
Ella Silk,Kate Harding,Marina Mahler et al.
Ella Silk et al.
Phages exert strong selective pressure on bacterial hosts, yet the role of abiotic factors in resistance evolution is often overlooked. Abiotic effects can shape both demographic factors, such as encounter rates, and trade-offs between resi...
Tyler Clabby,Florian Tesson,Baptiste Gaborieau et al.
Tyler Clabby et al.
While it is well established that bacterial genomes encode multiple and diverse antiphage systems, the reasons for their co-occurrence and their heterogeneous distribution remain debated. This review examines why bacteria accumulate antipha...
Phage defence-system abundances vary across environments and increase with viral density [0.03%]
溶源菌的防御系统丰度在不同环境中的分布及随着病毒密度的变化而增加
Sean Meaden,Edze R Westra,Peter C Fineran
Sean Meaden
The defence systems bacteria use to protect themselves from their viruses are mechanistically and genetically diverse. Yet the ecological conditions that predict when defences are selected for remain unclear, as substantial variation in def...
Melanie Blokesch,Kimberley D Seed
Melanie Blokesch
Cholera remains a significant global health burden. The causative agent responsible for the ongoing cholera pandemic, which began in 1961, is the seventh pandemic El Tor (7PET) lineage of Vibrio cholerae. Over the past century, lineages of ...
Kevin Barthes,Francois Rousset,Tanita Wein
Kevin Barthes
Viruses are ubiquitous biological entities that exert immense selective pressures on their hosts, driving the evolution of diverse innate immune mechanisms across all domains of life. While innate immunity has historically been studied in e...
Phage susceptibility to a minimal, modular synthetic CRISPR-Cas system in Pseudomonas aeruginosa is nutrient dependent [0.03%]
铜绿假单胞菌中噬菌体对最小模块化合成CRISPR-Cas系统的敏感性受营养条件影响
Josie F K Elliott,Keira Cozens,Yueyi Cai et al.
Josie F K Elliott et al.
CRISPR-Cas systems can provide adaptive, heritable immunity to their prokaryotic hosts against invading genetic material such as phages. It is clear that the importance of acquiring CRISPR-Cas immunity to anti-phage defence varies across en...
Systematic functional assessment of anti-phage systems in their native host [0.03%]
噬菌体天然宿主中抗噬菌体系统的系统功能评估
Ellie David,Clarisse Plantady,Sophiane Poissonnier et al.
Ellie David et al.
Bacterial resistance to bacteriophages (phages) relies on two primary strategies: preventing phage attachment and blocking post-attachment steps. These post-attachment mechanisms are mediated by diverse defence systems, including DNA-degrad...
The ecology and evolution of microbial immune systems: a look on the wild vibrio side [0.03%]
微生物免疫系统的生态与进化：来自野生维氏菌群的一瞥
Frederique Le Roux
Frederique Le Roux
Natural populations of vibrio beyond the well-studied pandemic strains of Vibrio cholerae, provide a powerful model for investigating the eco-evolutionary dynamics of microbial immune systems. Their genetic diversity, ecological versatility...
Phage provoke growth delays and SOS response induction despite CRISPR-Cas protection [0.03%]
噬菌体导致生长迟缓和SOS反应的诱导，即使有CRISPR-Cas保护
Benoit J Pons,Urszula Łapińska,Iolanda Lopes-Domingues et al.
Benoit J Pons et al.
Bacteria evolve resistance against their phage foes with a wide range of resistance strategies whose costs and benefits depend on the level of protection they confer and on the costs for maintainance. Pseudomonas aeruginosa can evolve resis...