Brandon Paarwater,Doty Ojwach,Nicole Prins et al.
Brandon Paarwater et al.
Elucidating how HIV and cytomegalovirus (CMV) co-infection in pregnancy disrupts immune homeostasis at the maternal-fetal interface can provide a foundation for developing intervention strategies to improve infant and maternal health. Of im...
The urgent search for predictive biomarkers in the emerging era of universal congenital cytomegalovirus screening [0.03%]
新生儿巨细胞病毒感染普遍筛查时代的预测生物标志物的迫切搜寻工作
Mark R Schleiss
Mark R Schleiss
In utero acquisition of cytomegalovirus (CMV) represents the most common infectious cause of paediatric developmental disability. With a global prevalence of approximately 0.7%, congenital CMV (cCMV) infection can produce wide-ranging injur...
Mapping CMV-related immune signatures in blood, aorta and perivascular mediastinal adipose tissue [0.03%]
血液、主动脉和血管周围纵隔脂肪组织中与CMV相关的免疫特征映射
Cassia Labeb,Laventa M Obare,Quanhu Sheng et al.
Cassia Labeb et al.
Cytomegalovirus (CMV) establishes lifelong latency and is linked to immunosenescence in older and immunocompromised individuals. We hypothesize that CMV drives systemic and tissue-specific immune changes that may contribute to cardiovascula...
Does cytomegalovirus infection increase the risk of tuberculosis in UK children? [0.03%]
英国儿童巨细胞病毒感染会增加患结核病的风险吗？
Sarah May Johnson,Elizabeth Whittaker,James Seddon et al.
Sarah May Johnson et al.
There is a hypothesized association between pre-existing cytomegalovirus (CMV) infection and risk of acquiring tuberculosis (TB). We aimed to explore if CMV seroprevalence and CMV IgG levels in children were associated with TB disease or My...
The immunomodulatory role of human cytomegalovirus in cancer in the era of checkpoint immunotherapy [0.03%]
人巨细胞病毒在免疫检查点治疗时代的癌症免疫调节作用
Julia Bremke,Cecilia Jay,Martin Little et al.
Julia Bremke et al.
This review discusses the role of chronic human cytomegalovirus (HCMV) infection in patients receiving immune checkpoint blockade (ICB) treatment against different malignancies, with an especial focus on malignant melanoma. We briefly outli...
Valganciclovir for cytomegalovirus viraemia in advanced HIV disease: a phase 2b randomized placebo-controlled trial of valganciclovir for cytomegalovirus viraemia in adults and adolescents with advanced HIV disease [0.03%]
艾滋病晚期巨细胞病毒血症的缬更昔洛韦治疗：一项评价缬更昔洛韦对成人及青少年HIV感染患者CMV血症疗效和安全性的随机、双盲、安慰剂对照IIb期临床试验
Jayne Ellis,Laura Joan Nsangi,Mohammed Rassool et al.
Jayne Ellis et al.
Mortality among adults hospitalized with advanced HIV disease (AHD; CD4 20%; there is an urgent need to evaluate strategies to reduce mortality within this extremely high-risk group. Approximately 50% of adults with CD4 counts
The indirect effects of cytomegalovirus infection-mechanisms and consequences [0.03%]
人类巨细胞病毒的间接效应-机制及后果
Tom A Yates,Helen Payne,Blair L Strang
Tom A Yates
In this introduction, we summarize the research papers, review articles, opinion pieces and important aspects of the facilitated discussion from the meeting 'The indirect effects of cytomegalovirus infection: mechanisms and consequences' he...
Impact of cytomegalovirus infection on heterologous vaccine responsiveness [0.03%]
巨细胞病毒感染对异基因疫苗反应性的影响
Francesco Nicoli,Urs Karrer,Victor Appay
Francesco Nicoli
Persistent infection with cytomegalovirus (CMV) induces massive cellular immune responses in humans. Over time, CMV infection leads to the accumulation of differentiated oligoclonal αβ T cells, NK cells and γδ T cells, a phenomenon ofte...
The immune response to human cytomegalovirus: impact of age, co-morbidities and the significance of anti-viral activity assessment [0.03%]
人类巨细胞病毒的免疫反应：年龄、合并症的影响以及抗病毒活性评估的意义
Sarah Elizabeth Jackson,Mahlaqua Noor,Eleanor Lim et al.
Sarah Elizabeth Jackson et al.
Understanding how all the components of the immune system respond to human cytomegalovirus (HCMV) primary infection and subsequent reactivation events is necessary to be able to successfully treat patients suffering from HCMV-mediated disea...
Jonathan Savitz
Jonathan Savitz
Cytomegalovirus (CMV), a common herpesvirus that establishes enduring latent infections, is increasingly recognized as a potential pathological co-factor in diverse medical disorders that are characterized by immunosuppression and/or inflam...