Definitive carbon ion radiotherapy for thoracic bone and soft tissue sarcoma [0.03%]
definitive碳离子放射治疗胸部骨和软组织肉瘤
Jian Chen,Ningyi Ma,Yaqi Li et al.
Jian Chen et al.
Background: Thoracic bone and soft tissue sarcoma (BSTS) represents a rare malignancy. For patients with medically inoperable BSTS, radiotherapy (RT) is a recommended treatment modality. Carbon ion radiotherapy (CIRT) has...
Inhibition of the ATR-CHK1 signaling pathway sensitizes MCPyV-positive Merkel cell carcinoma to gemcitabine [0.03%]
ATR-CHK1信号通路的抑制能使MCPyV阳性的 Merkel 细胞癌对吉西他滨敏感
Evelyn V Proctor,Sherine F Elsawa,Sarah R Walker et al.
Evelyn V Proctor et al.
Merkel cell carcinoma (MCC) is the primary cutaneous neuroendocrine carcinoma with a mortality rate higher than that of melanoma and other common skin cancers. In the United States, most cases of MCC are positive for Merkel cell polyomaviru...
Treatment outcomes of fruquintinib combined with PD-1 inhibitors in advanced colorectal cancer: a reconstructed patient-level meta-analysis of retrospective real-world studies [0.03%]
呋喹替尼联合PD-1抑制剂治疗晚期结直肠癌疗效的回顾性真实世界研究患者级别meta分析
Yan Liu,Jing-Ting He,Guo-He Lin et al.
Yan Liu et al.
Background: Fruquintinib is an established treatment option for patients with advanced colorectal cancer (CRC) who have progressed after standard therapies, including oxaliplatin- and irinotecan-based chemotherapy. Althou...
Validation and prognostic utility of the mSMART 4.0 risk stratification system in Chinese patients with multiple myeloma [0.03%]
在中国多发性骨髓瘤患者中验证并评估mSMART 4.0风险分层系统的预后价值
Jian Yin,Rui Liu,Yanping Zhang et al.
Jian Yin et al.
Objective: The 2024 Mayo Clinic mSMART 4.0 risk stratification system features significant revisions, yet its utility in Chinese multiple myeloma (MM) patients remains unvalidated. This study evaluates its prognostic perf...
Clinical prognostic value of homologous recombination repair axis markers and PARP1 expression in breast cancer: a systematic review, meta-analysis, and independent cohort validation [0.03%]
乳腺癌同源重组修复轴标志物和PARP1表达的临床预后价值：系统性回顾、荟萃分析及独立队列验证
Kezhen Shen,Lei Cai,Wei Wu
Kezhen Shen
Background: Resistance to poly ADP-ribose polymerase (PARP) inhibitors limits durable clinical benefit in breast cancer. The translational relevance of resistance-associated genes to patient prognosis remains poorly chara...
FOLFOX-HAIC plus regorafenib for the treatment of unresectable colorectal liver metastases refractory to first and second-line systemic chemotherapy [0.03%]
对于一线和二线系统化疗无效的不可切除结直肠肝转移患者采用FOLFOX-HAIC联合瑞戈非尼治疗
Jiacheng Liu,Songlin Song,Wei Yao et al.
Jiacheng Liu et al.
Background: Hepatic arterial infusion chemotherapy (HAIC) is a potentially attractive locoregional therapy for patients with unresectable colorectal liver metastases (CRLM). This study aimed to evaluate the safety and eff...
Combining tertiary lymphoid structures and tumor stroma percentage for predicting prognosis and chemotherapy benefits in stage II-III colorectal cancer [0.03%]
三级淋巴结构与肿瘤间质比例在II-III期结直肠癌预后及化疗疗效预测中的应用研究
Kun Yang,Honghao Li,Xiaoyu Dong et al.
Kun Yang et al.
Background: The current tumor-node-metastasis (TNM) staging system is insufficient for predicting the prognosis and chemotherapeutic benefits in stage II-III colorectal cancer (CRC) patients. We aimed to evaluate whether ...
The Ki-67 proliferation index in tertiary lymphoid structures as a predictor of survival outcomes in patients with resectable non-small cell lung cancer [0.03%]
可切除非小细胞肺癌患者中肿瘤生发中心Ki-67增殖指数预测生存结局的作用研究
Xinyu Bao,Mei Xie,Xuwen Lin et al.
Xinyu Bao et al.
Background & objectives: Although the presence of tertiary lymphoid structures (TLS) has been associated with improved immunotherapy efficacy across multiple solid tumors, the prognostic significance of proliferative acti...
Stage-dependent prognostic value of clinical and pathological T staging in resected lung adenocarcinoma: a multicenter cohort study [0.03%]
基于多中心队列的临床及病理T分期对肺腺癌外科手术患者预后影响的阶段依赖性研究
Libing Yang,Chao Guo,Xin Du et al.
Libing Yang et al.
Background: Preoperative CT-based clinical T staging guides surgical planning in lung adenocarcinoma, whereas pathological T staging remains the postoperative reference standard. Prior studies have demonstrated discordanc...
Autologous stem cell transplantation for secondary central nervous system lymphoma: a multicentre retrospective analysis [0.03%]
自体干细胞移植治疗继发中枢神经系统淋巴瘤的多中心回顾性分析
Meredith W Tan,Victor Ling,Jing Yuan Tan et al.
Meredith W Tan et al.
Background: Secondary Central Nervous Lymphoma (SCNSL) is an aggressive lymphoma with poor outcomes. Consensus regarding consolidation with thiotepa-based autologous transplant (ASCT) for SCNSL is lacking. ...