Shikonin sensitizes A549 cells to TRAIL-induced apoptosis through the JNK, STAT3 and AKT pathways [0.03%]
漆酚通过JNK、STAT3和AKT途径增强TRAIL诱导的A549细胞凋亡敏感性
Zhi Lan Guo,Jing Zhe Li,Yan Yan Ma et al.
Zhi Lan Guo et al.
Background: TRAIL, tumor necrosis factor-related apoptosis-inducing ligand, can selectively kill cancer cells with little or no cytotoxicity toward normal human cells and is regarded as a potential relatively safe antitum...
Mitotic activity patterns and cytoskeletal changes throughout the progression of diapause developmental program in Daphnia [0.03%]
轮虫休眠发育程序渐进过程中的有丝分裂模式和细胞骨架变化
Luxi Chen,Rosemary E Barnett,Martin Horstmann et al.
Luxi Chen et al.
Background: Diapause is a form of dormancy that is genetically predetermined to allow animals to overcome harsh environmental conditions. It is induced by predictive environmental cues bringing cellular activity levels in...
Post-treatment de-phosphorylation of p53 correlates with dasatinib responsiveness in malignant melanoma [0.03%]
恶性黑色素瘤中p53去磷酸化与达沙替尼反应性相关
Josip Skoko,Jan Rožanc,Emilie M Charles et al.
Josip Skoko et al.
Background: Dasatinib (Sprycel) was developed as a tyrosine kinase inhibitor targeting Bcr-Abl and the family of Src kinases. Dasatinib is commonly used for the treatment of acute lymphoblastic and chronic myelogenous leu...
Comparative evaluation of mesenchymal stromal cells from umbilical cord and amniotic membrane in xeno-free conditions [0.03%]
无动物源培养基条件下脱细胞胎盘膜间充质干细胞与脐带间充质干细胞的比较研究
Yongxu Mu,Xiaoyun Wu,Zhiming Hao
Yongxu Mu
Background: Within the past years, umbilical cord (UC) and amniotic membrane (AM) expanded in human platelet lysate (PL) have been found to become increasingly candidate of mesenchymal stromal cells (MSCs) in preclinical ...
Comparative Study
BMC cell biology. 2018 Dec 13;19(1):27. DOI:10.1186/s12860-018-0178-8 2018
The STRIPAK complex components FAM40A and FAM40B regulate endothelial cell contractility via ROCKs [0.03%]
STRIPAK复合体成分FAM40A和FAM40B通过ROCKs调节内皮细胞收缩力
Narendra Suryavanshi,Joanna Furmston,Anne J Ridley
Narendra Suryavanshi
Background: Endothelial cells provide a barrier between blood and tissues, which is regulated to allow molecules and cells in out of tissues. Patients with cerebral cavernous malformations (CCM) have dilated leaky blood v...
Tylor R Lewis,Sean R Kundinger,Brian A Link et al.
Tylor R Lewis et al.
Background: KIF17, a kinesin-2 motor that functions in intraflagellar transport, can regulate the onset of photoreceptor outer segment development. However, the function of KIF17 in a mature photoreceptor remains unclear....
PIAS1 protects against myocardial ischemia-reperfusion injury by stimulating PPARγ SUMOylation [0.03%]
PIAS1通过刺激PPARγ的SUMO化对抗心肌缺血再灌注损伤
Bo Xie,Xinyu Liu,Jie Yang et al.
Bo Xie et al.
Background: Myocardial ischemia-reperfusion injury (IRI) has become one of the most serious complications after reperfusion therapy in patients with acute myocardial infarction. Small ubiquitin-like modification (SUMOylat...
Acetylation of C-terminal lysines modulates protein turnover and stability of Connexin-32 [0.03%]
C末端赖氨酸的乙酰化调控连接素-32的蛋白质周转和稳定性
Sarah R Alaei,Charles K Abrams,J Chloë Bulinski et al.
Sarah R Alaei et al.
Background: The gap junction protein, Connexin32 (Cx32), is expressed in various tissues including liver, exocrine pancreas, gastrointestinal epithelium, and the glia of the central and peripheral nervous system. Gap junc...
Inflammation caused by peripheral immune cells across into injured mouse blood brain barrier can worsen postoperative cognitive dysfunction induced by isoflurane [0.03%]
外周免疫细胞通过受损的血脑屏障进入小鼠大脑可加重异氟醚诱导的认知功能障碍
Honghua Zhu,Wei Liu,Hao Fang
Honghua Zhu
Background: Disruption to the blood brain barrier (BBB) is a leading factor associated with the development of postoperative cognitive dysfunction (POCD). Despite this, the underlying mechanism by which BBB disruption pro...
Tanshinone IIA reduces SW837 colorectal cancer cell viability via the promotion of mitochondrial fission by activating JNK-Mff signaling pathways [0.03%]
丹参酮ⅡA通过激活JNK-MFF信号通路促进线粒体分裂以降低SW837结肠癌细胞活力
Sayilaxi Jieensinue,Hong Zhu,Guangcheng Li et al.
Sayilaxi Jieensinue et al.
Background: Mitochondrial homeostasis has been increasingly viewed as a potential target of cancer therapy, and mitochondrial fission is a novel regulator of mitochondrial function and apoptosis. The aim of our study was ...