Molecular characterization of protein kinase C delta (PKCδ)-Smac interactions [0.03%]
蛋白激酶C delta(SPKCδ)-Smac相互作用的分子特征研究
Christian Holmgren,Louise Cornmark,Gry Kalstad Lønne et al.
Christian Holmgren et al.
Background: Protein kinase C δ (PKCδ) is known to be an important regulator of apoptosis, having mainly pro- but also anti-apoptotic effects depending on context. In a previous study, we found that PKCδ interacts with ...
Yasunori Fukuda,Osamu Sano,Kenichi Kazetani et al.
Yasunori Fukuda et al.
Background: In drug discovery research, cell-based phenotypic screening is an essential method for obtaining potential drug candidates. Revealing the mechanism of action is a key step on the path to drug discovery. Howeve...
Identification and characterization of the novel nuclease activity of human phospholipid scramblase 1 [0.03%]
人类磷脂 scramblase 1 的新型核酸酶活性的鉴定与表征
Ulaganathan Sivagnanam,Shweta Narayana Murthy,Sathyanarayana N Gummadi
Ulaganathan Sivagnanam
Background: Human phospholipid scramblase 1 (hPLSCR1) was initially identified as a Ca(2+) dependent phospholipid translocator involved in disrupting membrane asymmetry. Recent reports revealed that hPLSCR1 acts as a mult...
Altered activity patterns of transcription factors induced by endoplasmic reticulum stress [0.03%]
内质网压力诱发的转录因子活性模式改变
Sheena Jiang,Eric Zhang,Rachel Zhang et al.
Sheena Jiang et al.
Background: The endoplasmic-reticulum (ER) responds to the burden of unfolded proteins in its lumen by activating intracellular signal transduction pathways, also known as the unfolded protein response (UPR). Many signal ...
Conserved motif VIII of murine DNA methyltransferase Dnmt3a is essential for methylation activity [0.03%]
DNA甲基转移酶Dnmt3a保守模体VIII对其甲基化活性是必需的
Olga V Lukashevich,Natalia A Cherepanova,Renata Z Jurkovska et al.
Olga V Lukashevich et al.
Background: Dnmt3a is a DNA methyltransferase that establishes de novo DNA methylation in mammals. The structure of the Dnmt3a C-terminal domain is similar to the bacterial M. HhaI enzyme, a well-studied prokaryotic DNA m...
Linalool isomerase, a membrane-anchored enzyme in the anaerobic monoterpene degradation in Thauera linaloolentis 47Lol [0.03%]
刺鼠柠檬烯杆菌47lol株中单萜厌氧降解中的膜结合异构酶柠檬烯醇异构酶
Robert Marmulla,Barbara Šafarić,Stephanie Markert et al.
Robert Marmulla et al.
Background: Thauera linaloolentis 47Lol uses the tertiary monoterpene alcohol (R,S)-linalool as sole carbon and energy source under denitrifying conditions. The conversion of linalool to geraniol had been observed in carb...
1,2-Dichlorobenzene affects the formation of the phosphoenzyme stage during the catalytic cycle of the Ca(2+)-ATPase from sarcoplasmic reticulum [0.03%]
1,2-二氯苯对肌浆网Ca^(2+)-ATP酶催化循环中磷酶阶段形成的影响
Javier Vargas-Medrano,Jorge A Sierra-Fonseca,Luis F Plenge-Tellechea
Javier Vargas-Medrano
Background: 1,2-Dichlorobenzene (1,2-DCB) is a benzene-derived molecule with two Cl atoms that is commonly utilized in the synthesis of pesticides. 1,2-DCB can be absorbed by living creatures and its effects on naturally-...
Substrate specificity and function of acetylpolyamine amidohydrolases from Pseudomonas aeruginosa [0.03%]
来源于铜绿假单胞菌的酰基聚胺氨肽酶底物特异性及功能研究
Andreas Krämer,Jan Herzer,Joerg Overhage et al.
Andreas Krämer et al.
Background: Pseudomonas aeruginosa, a Gram-negative, aerobic coccobacillus bacterium is an opportunistic human pathogen and worldwide the fourth most common cause of hospital-acquired infections which are often high morta...
Erratum to: Purification and characterization of a cytochrome c with novel caspase-3 activation activity from the pathogenic fungus Rhizopus arrhizus [0.03%]
戎氏毛霉病原真菌中具有新型caspase-3激活活性的细胞色素c的纯化与鉴定(刊误)
Manoj Saxena,Rohit Kumar Sharma,Josell Ramirez-Paz et al.
Manoj Saxena et al.
Published Erratum
BMC biochemistry. 2016 Feb 19:17:3. DOI:10.1186/s12858-016-0059-8 2016
Characterization of a cold-active and salt tolerant esterase identified by functional screening of Arctic metagenomic libraries [0.03%]
通过功能筛选北极元基因文库鉴定并表征了一种耐盐冷活性酯酶
Concetta De Santi,Bjørn Altermark,Marcin Miroslaw Pierechod et al.
Concetta De Santi et al.
Background: The use of metagenomics in enzyme discovery constitutes a powerful approach to access to genomes of unculturable community of microorganisms and isolate novel valuable biocatalysts for use in a wide range of b...