Use of a special Brazilian red-light emitting railroad worm Luciferase in bioassays of NEK7 protein Kinase and Creatine Kinase [0.03%]
一种特殊巴西红光 Railroad 萤火虫荧光素酶在NEK7蛋白激酶和肌酸激酶生物测定中的应用研究
Arina Marina Perez,Bruno Aquino,Vadim Viviani et al.
Arina Marina Perez et al.
Background: Luciferases, enzymes that catalyze bioluminescent reactions in different organisms, have been extensively used for bioanalytical purposes. The most well studied bioluminescent system is that of firefly and oth...
Dacin, one metalloproteinase from Deinagkistrodon acutus venom inhibiting contraction of mouse ileum muscle [0.03%]
尖吻腹蛇毒液中一种金属蛋白酶DACIN抑制小鼠回肠平滑肌收缩的作用研究
Bin Zhou,Gang Liu,Qiyi He et al.
Bin Zhou et al.
Background: Mice were bitten by five-pace vipers (Deinagkistrodon acutus), and then envenomed. It was well-known that the snake venom mainly disturbed the blood homeostasis of the envenomed victims. Ocassionally, we found...
Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor [0.03%]
一种光诱导的偶氮桥联磺化萘酚二聚体作为PTP1B抑制剂的研究发现
Robert D Bongard,Michael Lepley,Khushabu Thakur et al.
Robert D Bongard et al.
Background: Protein tyrosine phosphatases (PTPs) like dual specificity phosphatase 5 (DUSP5) and protein tyrosine phosphatase 1B (PTP1B) are drug targets for diseases that include cancer, diabetes, and vascular disorders ...
Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem [0.03%]
生物亚胺和泰比 penem 对结核分枝杆菌非经典转肽酶LdtMt2 消活的结构见解
Mario A Bianchet,Ying H Pan,Leighanne A Brammer Basta et al.
Mario A Bianchet et al.
Background: The carbapenem subclass of β-lactams is among the most potent antibiotics available today. Emerging evidence shows that, unlike other subclasses of β-lactams, carbapenems bind to and inhibit non-classical tr...
Chemical and structural characterization of α-N-acetylgalactosaminidase I and II from starfish, asterina amurensis [0.03%]
海星 Asterina amurensisα-氨基半乳糖苷酶I和II的化学及结构鉴定
Md Harun-Or Rashid,Golam Sadik,Ahm Khurshid Alam et al.
Md Harun-Or Rashid et al.
Background: The marine invertebrate starfish was found to contain a novel α-N-acetylgalactosaminidase, α-GalNAcase II, which catalyzes removal of terminal α-N-acetylgalactosamine (α-GalNAc), in addition to a typical ...
CrMAPK3 regulates the expression of iron-deficiency-responsive genes in Chlamydomonas reinhardtii [0.03%]
CrMAPK3调控铁缺乏响应基因在小立氏盘藻中的表达
Xiaowen Fei,Junmei Yu,Yajun Li et al.
Xiaowen Fei et al.
Background: Under iron-deficient conditions, Chlamydomonas exhibits high affinity for iron absorption. Nevertheless, the response, transmission, and regulation of downstream gene expression in algae cells have not to be i...
Structural similarities and functional differences clarify evolutionary relationships between tRNA healing enzymes and the myelin enzyme CNPase [0.03%]
结构相似性和功能差异阐明了修复tRNA的酶与髓磷脂酶CNPase之间的进化关系
Gopinath Muruganandam,Arne Raasakka,Matti Myllykoski et al.
Gopinath Muruganandam et al.
Background: Eukaryotic tRNA splicing is an essential process in the transformation of a primary tRNA transcript into a mature functional tRNA molecule. 5'-phosphate ligation involves two steps: a healing reaction catalyze...
Binding of smoothelin-like 1 to tropomyosin and calmodulin is mutually exclusive and regulated by phosphorylation [0.03%]
平滑蛋白样1与肌动蛋白的结合与其磷酸化调节互斥
Annegret Ulke-Lemée,David Hao Sun,Hiroaki Ishida et al.
Annegret Ulke-Lemée et al.
Background: The smoothelin-like 1 protein (SMTNL1) can associate with tropomyosin (Tpm) and calmodulin (CaM), two proteins essential to the smooth muscle contractile process. SMTNL1 is phosphorylated at Ser301 by protein ...
Increased enzymatic hydrolysis of sugarcane bagasse by a novel glucose- and xylose-stimulated β-glucosidase from Anoxybacillus flavithermus subsp. yunnanensis E13T [0.03%]
一株来源于云南热泉的芽孢杆菌新种高效葡萄糖及木糖诱导型β-葡萄糖苷酶的发现及应用
Yang Liu,Rui Li,Jing Wang et al.
Yang Liu et al.
Background: β-Glucosidase is claimed as a key enzyme in cellulose hydrolysis. The cellulosic fibers are usually entrapped with hemicelluloses containing xylose. So there is ongoing interest in searching for glucose- and ...
Edna Blotnick,Asaf Sol,Gilad Bachrach et al.
Edna Blotnick et al.
Background: Histatins are histidine rich polypeptides produced in the parotid and submandibular gland and secreted into the saliva. Histatin-3 and -5 are the most important polycationic histatins. They possess antimicrobi...