Kim Baumann
Kim Baumann
Critical constituents and assembly principles of centriole biogenesis in human cells [0.03%]
人类细胞中心粒生物发生的关键组成成分及其装配原则
Pierre Gönczy
Pierre Gönczy
The centriole is an evolutionarily conserved microtubule-bearing organelle with a striking 9-fold symmetrical architecture that is crucial for fundamental cellular processes in eukaryotes, including polarity, signalling and motility. The la...
Shiri Gur-Cohen
Shiri Gur-Cohen
M Burigotto,J G Carlton
M Burigotto
The endosomal sorting complex required for transport (ESCRT) machinery is an evolutionarily conserved multisubunit protein complex that remodels cellular membranes. Beyond its classical role in endosomal sorting, the ESCRT machinery has bee...
The dynamic and heterogeneous composition of biomolecular condensates and its functional relevance [0.03%]
生物分子凝聚体的动态和异质组成及其功能相关性
Christopher Chin Sang,Sayantani Upadhyay,Michael L Nosella et al.
Christopher Chin Sang et al.
Biomolecular condensates are non-membrane-encapsulated compartments that control various biological processes, largely by enriching and excluding certain molecules. Emerging evidence demonstrates that condensate compositions dynamically cha...
Mechanisms of transcription-coupled repair and DNA damage surveillance in health and disease [0.03%]
转录偶联修复和DNA损伤监察在健康与疾病中的机制
Marjolein van Sluis,Camila Gonzalo-Hansen,Qingrong Li et al.
Marjolein van Sluis et al.
RNA polymerase II (Pol II)-mediated gene transcription is frequently disrupted by DNA damage from various sources. Transcription-blocking DNA lesions hinder the progression of elongating Pol II, leading to transcription stress that, if unre...
Timo N Kohler
Timo N Kohler
Sushant Bangru,Rocky Diegmiller,Stefano Di Talia et al.
Sushant Bangru et al.
Tissue regeneration has historically been the subject of intense scientific scrutiny, from basic biology to applications in regenerative medicine. Use of model organisms and cutting-edge technologies have uncovered various mechanisms of reg...