A call for studying the impact of multiple stressors on biological systems [0.03%]
呼吁研究多种压力因素对生物系统的影响
Ron Mittler,Sara I Zandalinas,Matthias C Rillig
Ron Mittler
Mechanisms of transcription termination across the coding and noncoding loci of the genome [0.03%]
基因组编码和非编码位点的转录终止机制
Aixia Song,Minhui Hu,Fei Xavier Chen
Aixia Song
Transcription termination by RNA polymerase II (Pol II) defines transcriptional boundaries of protein-coding and noncoding transcription units throughout the genome. Rather than being a passive endpoint of elongation, termination is a tight...
Andrea Musacchio,Pim J Huis In &#x;t Veld,Rae R Brown et al.
Andrea Musacchio et al.
The kinetochore is the complex molecular machine that controls chromosome segregation. The kinetochore comprises two regions: the inner kinetochore, which assembles on the specialized chromatin structure of the centromere, and the outer kin...
Rae R Brown,Pim J Huis In &#x;t Veld,Andrea Musacchio et al.
Rae R Brown et al.
Accurate chromosome segregation in eukaryotic cells ensures that each daughter cell receives the same chromosome complement during cell division. Key to this process is the kinetochore, a macromolecular complex that connects spindle microtu...
Eytan Zlotorynski
Eytan Zlotorynski
Regulation of RNA transcript elongation in metazoans and its relevance to disease [0.03%]
后生动物中RNA转录延伸的调控及其与疾病的关系
Claudia A Mimoso,Isaac Fianu,Karen Adelman
Claudia A Mimoso
Our understanding of transcript elongation by metazoan RNA polymerase II (Pol II) has grown notably in recent years. Advances in structural biology have defined the interactions that underlie promoter-proximal pausing of Pol II and the tran...
Alexander Johnson-Buck,Adrien Chauvier,Abrar A Abidi et al.
Alexander Johnson-Buck et al.
The classical view of gene regulation complexes as stable, modular machines needs amending based on emerging insights into their dynamic nature. Whereas recent advances in structural biology have provided high-resolution snapshots of these ...
Modulating the degree of X-inactivation escape to establish causal links to sex-biased disease [0.03%]
调节X染色体失活逃逸的程度以建立与性别偏向性疾病的相关性
Sarah Hoelzl,Daniel Andergassen
Sarah Hoelzl
Wen-Yu Zhu,Ilias Skeparnias,Athanasios-Nasir Shaukat et al.
Wen-Yu Zhu et al.
The biogenesis, modifications and function of mitochondrial transfer RNAs (mt-tRNAs) reflect the symbiotic relationship and coordinated evolution between the domesticated organelle and the outer cell. Through evolution, mt-tRNA structures h...
Yuanxin Yang,Huipeng Jiao,Daichao Xu
Yuanxin Yang
Necroptosis is a programmed lytic cell death pathway executed through mixed lineage kinase domain-like protein (MLKL)-driven plasma membrane disruption and has pivotal roles in both health and disease. Recent advances have led us to propose...