Lisa Heinke
Lisa Heinke
Anticancer effects of zotatifin are mediated by RNA structure remodelling [0.03%]
Zotatifin的抗癌作用通过RNA结构重塑介导
Caroline Barranco
Caroline Barranco
Carrie Bernecky
Carrie Bernecky
Ahmet Yildiz
Ahmet Yildiz
Published Erratum
Nature reviews. Molecular cell biology. 2025 Mar 26. DOI:10.1038/s41580-025-00845-0 2025
Mechanisms and regulation of DNA end resection in the maintenance of genome stability [0.03%]
DNA末端切除在维持基因组稳定性中的机制和调控
Raphael Ceccaldi,Petr Cejka
Raphael Ceccaldi
DNA end resection is a crucial early step in most DNA double-strand break (DSB) repair pathways. Resection involves the nucleolytic degradation of 5' ends at DSB sites to generate 3' single-stranded DNA overhangs. The first, short-range res...
Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway [0.03%]
分泌途径中COPII被膜囊泡的组装及其承运物识别机制
Katie W Downes,Giulia Zanetti
Katie W Downes
One third of all proteins in eukaryotes transit between the endoplasmic reticulum (ER) and the Golgi to reach their functional destination inside or outside of the cell. During export, secretory proteins concentrate at transitional zones of...
Yang Bai,Youdong Pan,Xing Liu
Yang Bai
Pyroptosis, a novel mode of inflammatory cell death, is executed by membrane pore-forming gasdermin (GSDM) family members in response to extracellular or intracellular injury cues and is characterized by a ballooning cell morphology, plasma...
Irene Chiolo,Matthias Altmeyer,Gaëlle Legube et al.
Irene Chiolo et al.
Changes in nuclear shape and in the spatial organization of chromosomes in the nucleus commonly occur in cancer, ageing and other clinical contexts that are characterized by increased DNA damage. However, the relationship between nuclear ar...
Sarah J Bray,Anna Bigas
Sarah J Bray
Many different animal developmental and homeostatic processes rely on signalling via the highly conserved Notch pathway. Often Notch signalling has iterative roles during cell specification and differentiation, controlling not only the stat...
Aytug Tuncel,Changtian Pan,Joshua S Clem et al.
Aytug Tuncel et al.
Growing world population and deteriorating climate conditions necessitate the development of new crops with high yields and resilience. CRISPR-Cas-mediated genome engineering presents unparalleled opportunities to engineer crop varieties ch...