Erich Bornberg-Bauer,Lars A Eicholt
Erich Bornberg-Bauer
De novo genes generally refer to genes that arise from previously non-coding sequences. This evolutionary path - when randomly expressed sequences become folded and active proteins - challenges our understanding of genetic innovation and ha...
Lauren J Hodkinson,Erica N Larschan
Lauren J Hodkinson
Regulation of gene expression by alternative polyadenylation in health and disease [0.03%]
健康与疾病中基因表达的可变poly腺苷酸化调节机制研究进展
Bin Tian,Shan Yu,Qiang Zhang
Bin Tian
More than half of the human protein-coding genes display alternative polyadenylation (APA), whereby 3'-end processing of the nascent RNA takes place at different sites. APA leads to mRNA isoforms containing different 3' untranslated regions...
Isabel K Schuurmans,Janine F Felix,Matthew Suderman et al.
Isabel K Schuurmans et al.
Benjamin S Freedman,Jeff W M Bulte,Bruce R Conklin et al.
Benjamin S Freedman et al.
CRISPR-based genome editing therapeutics are entering the clinic, offering transformative potential but also presenting potential risks. Preclinical-to-clinical toolkits are needed to assess the safety and efficacy of these new therapies an...
Yubao Cheng
Yubao Cheng
Kate E Jaggi,Savannah J Hoyt,Rachel J O&#x;Neill et al.
Kate E Jaggi et al.
Human centromeres are large, complex chromosomal loci that serve as the foundation for kinetochore assembly, contribute to chromosome architecture and sister chromatid cohesion, and participate in chromosome separation during cell division....
Ancestral diversity in complex disease genetics: from discovery to translation [0.03%]
复杂疾病的遗传学：从发现到转化医学中的祖先多样性研究
Karoline Kuchenbaecker,Georgina Navoly
Karoline Kuchenbaecker
The expansion of ancestrally diverse genetic cohorts has altered the landscape of complex disease genetics. Differences in linkage disequilibrium across populations have improved fine-mapping and the identification of target genes - key ste...
Proteoform medicine: characterizing and targeting protein forms in human disease [0.03%]
蛋白药理学：人类疾病条件下蛋白形式的鉴定与靶向作用
Jennifer A Korchak,S Stephen Yi,Neil L Kelleher et al.
Jennifer A Korchak et al.
Proteoforms are the diverse molecular protein species produced from a single gene through genetic variation, alternative splicing and post-translational modifications. They are the crucial link between genotype and phenotype. There are esti...
From models to molecules: self-organized and instructed modes of developmental patterning [0.03%]
从模型到分子：发育模式的自组织和指令模式
David B Brückner
David B Brückner