Yanyu Zhu,W E Moerner,Lei S Qi
Yanyu Zhu
The 3D architecture and dynamics of the genome are crucial for regulation of genome stability, transcription and cellular function. CRISPR-based live imaging technologies have enabled real-time visualization of specific genomic loci and tra...
Kaihang Wang
Kaihang Wang
Huiqi Lin,Lulu Ding,XinYue Hu et al.
Huiqi Lin et al.
Emilie Brasset
Emilie Brasset
Michael Poeschla,Vijay G Sankaran
Michael Poeschla
Haematopoiesis has long been a paradigm for understanding how human genetic variation can influence physiology in health and disease, ranging from the genetic characterization of Mendelian blood diseases to population-scale genomic studies ...
Manfred Kayser
Manfred Kayser
Published Erratum
Nature reviews. Genetics. 2026 Mar 20. DOI:10.1038/s41576-026-00953-3 2026
Yousuf A Khan
Yousuf A Khan
Ana Palma Teixeira,Dominique Aubel,Martin Fussenegger
Ana Palma Teixeira
Engineered cell therapies are transforming precision medicine by enabling real-time, context-responsive interventions that act upon disease-specific cues. Inspired by the success of CAR-T cells in oncology, next-generation platforms are bei...
Gene regulatory networks: from correlative models to causal explanations [0.03%]
从相关模型到因果解释的基因调控网络研究
Rory J Maizels,James Briscoe
Rory J Maizels
Gene regulatory networks (GRNs) explain how the genome controls cellular behaviour and tissue morphogenesis, serving to connect molecular mechanism to functional output. Single-cell technologies now provide descriptions of these networks wi...
Elizabeth A Cummins,Priyanshu Singh Raikwar,Eve Hallett et al.
Elizabeth A Cummins et al.
Precise genotype-phenotype mapping is essential in applied microbiology, from engineering genetically modified strains to developing tailored strategies for antimicrobial therapies. Comparative genomics often treats genes as independent con...