Programmed axon degeneration: mechanism, inhibition and therapeutic potential [0.03%]
程序性轴突退行：机制、抑制与治疗潜力
Andrea Loreto,Lukas J Neukomm
Andrea Loreto
Programmed axon degeneration (PAxD) is an evolutionarily conserved mechanism in the nervous system that is activated by axonal injury (axotomy) to execute the self-destruction of a severed distal axon. It can also be triggered by non-axotom...
Integrated recall arousal [0.03%]
综合回忆唤醒模型
Jake Rogers
Jake Rogers
Sian Lewis
Sian Lewis
Frank F Lanfranchi
Frank F Lanfranchi
Katherine Whalley
Katherine Whalley
Sanjay M Sisodiya
Sanjay M Sisodiya
Takayuki Yamashita
Takayuki Yamashita
The evolutionary origins of synaptic proteins and their changing roles in different organisms across evolution [0.03%]
突触蛋白的进化起源及其在不同生物中的变化功能
Jeffrey J Colgren,Pawel Burkhardt
Jeffrey J Colgren
The question of how the first synapses and neurons evolved remains unanswered. Chemical synapses are highly organized functional assemblies, linking two cells between presynaptic and postsynaptic structures. The core set of proteins making ...
Victor P Mathis,Aliza T Ehrlich,Emmanuel Darcq
Victor P Mathis
The increasing prevalence of opioid use disorder (OUD) represents an important global public health crisis, often referred to as the 'opioid epidemic'. Opioids are known for their potent pain-relieving effects, but also have serious side ef...