eIF3: a critical player in mRNA recruitment to the ribosome with emerging roles across translation [0.03%]
吴若愚，王晨歌，舒明春｜eIF3：参与招募mRNA到核糖体的重要因子及其在翻译过程中的新角色
Nicholas A Ide,Sufana Noorwez,Christine Xu et al.
Nicholas A Ide et al.
Eukaryotic translation initiation factor (eIF) 3 is a multi-subunit protein complex that plays critical roles throughout translation initiation and has been implicated in a variety of human diseases. More recently, eIF3 has been tied to tra...
Heparan sulphate and neural development: dissecting the roles of astrocyte-expressed heparan sulphate [0.03%]
肝硫酸盐与神经发育：分离星形胶质细胞表达的肝硫酸盐的作用
Martina Gyimesi,Rachel K Okolicsanyi,Larissa M Haupt
Martina Gyimesi
Astrocytes are key regulators of neurogenesis, synaptogenesis, synaptic transmission and the clearance of pathological factors within the brain, while maintaining homeostasis throughout life. They also aid in the establishment and maintenan...
Ionel Popa,Ronen Berkovich
Ionel Popa
Mechanical forces play a pivotal role in cellular processes, acting as molecular switches that encode, store, and retrieve information, thereby facilitating a form of molecular memory. This review explores how protein unfolding and refoldin...
A busy BOD1-y: the diverse functions of an intracellular signaling regulatory protein family [0.03%]
繁忙的BOD1家族：一种细胞内信号转导调控蛋白家族的多种功能
Thomas J Kucharski,Martin R Higgs,Duane A Compton et al.
Thomas J Kucharski et al.
The biorientation-defective (BOD) protein family, comprising BOD1, BOD1L1 (BOD1-like 1), and BOD1L2, plays critical and diverse roles in fundamental cellular processes, including mitosis, DNA repair, neurological function, and metabolism. B...
Catalytic-independent roles of chromatin modifiers in mammalian development and the implications for treating human disease [0.03%]
染色质修饰酶的非催化作用在哺乳动物发育及人类疾病治疗中的意义
Hannah K Vanyai,Marnie E Blewitt
Hannah K Vanyai
The molecular function of chromatin modifiers is canonically assumed to be directly related to their enzymatic activities and these activities are typically measured when investigating the molecular consequences of manipulation in model sys...
Leonid V Chernomordik,Kamran Melikov
Leonid V Chernomordik
Multinucleated osteoclasts, generated by fusion of mononucleated precursors, play an essential role in the lifelong remodeling of our bones. Since within the physiological range of osteoclast sizes, their bone-resorbing activity grows with ...
Regulation via compartmentation: adaptive localization of the proteasome under stress [0.03%]
隔室化调控：应激条件下蛋白酶体的适应性定位
Aaron Ciechanover,Ido Livneh
Aaron Ciechanover
Protein degradation by the ubiquitin-proteasome system and autophagy are essential mechanisms that are involved in virtually all cellular activities, and their inadequate function was shown to underlie the pathogenesis of various medical co...
Towards a phylogenetically informed approach to solving protein-protein interactions [0.03%]
一种解决蛋白质-蛋白质相互作用的系统发育方法的研究
Chun Shen Lim,Peter Mace,Peter C Fineran et al.
Chun Shen Lim et al.
Protein-protein interactions (PPIs) are critical to all cellular activities. Despite having a large number of proteins, cells have spatial and temporal control over PPIs to avoid dysregulation in cellular pathways. Considerable research eff...
Liquan Huang,Yuan-Yuan Peng,Defu Yu
Liquan Huang
Tuft cells are a rare type of epithelial cells characterized not only by their tuft-like structure but also by the expression of specific genes, including those encoding the transcription factor Pou2f3 and canonical gustatory signaling prot...
Unraveling the interplay of DNA methylation and chromosome organization [0.03%]
揭秘DNA甲基化与染色体高级结构的相互作用
Yuhe Pei,Guoqiang Li
Yuhe Pei
Eukaryotic DNA has been covalently modified by DNA methylation and folded into a three-dimensional conformation in the nucleus. While the functions of DNA methylation and chromosome organization have been widely discussed, respectively, the...