Orel Paz,Tamir Gonen
Orel Paz
Membrane proteins are essential to cellular signaling, transport, and homeostasis, yet their amphipathic nature, dependence on lipids or detergents, and typically difficult expression and purification make them difficult targets for structu...
TAM receptor tyrosine kinases as potential mediators of the non-lytic spread of non-enveloped viruses [0.03%]
Steven J Moran,Chrystal A Starbird
Steven J Moran
Tyro3, Axl, and Mer are receptor tyrosine kinases that comprise the TAM receptor family. These receptors, originally identified as orphan receptors, do not bind growth factors but rather ligands that can facilitate processes such as phagocy...
Thomas Kierspel,Emiliano de Santis,Kira Schamoni-Kast et al.
Thomas Kierspel et al.
Small-angle X-ray scattering (SAXS) is a powerful and widely used technique for structural biology, providing information about solution structures, i.e., without the need for crystallization or cryogenic conditions. However, its applicabil...
Rho GTPases in cancer resistance: mechanisms, vulnerabilities, and therapeutic opportunities [0.03%]
Amy Beaudin,Philippe Lefrançois,Mélanie Laurin
Amy Beaudin
Intrinsic and adaptive resistance to therapy remain major barriers to effective cancer treatment. Diverse resistance mechanisms, including epithelial-mesenchymal transition, enhanced tolerance to DNA damage, impaired cell death pathways, me...
Subhrajyoti Dolai,Amer Alam
Subhrajyoti Dolai
ATP-binding cassette (ABC) transporters are essential membrane proteins that couple ATP hydrolysis to move diverse substrates across lipid bilayers through large-scale conformational changes. In humans, 48 ABC transporters span seven subfam...
MGRN1 in development and disease: a unifying view of a versatile membrane-tethered E3 ubiquitin ligase [0.03%]
MGRN1在发育和疾病中的作用：一个多功能的膜连接E3泛素连接酶的统一观点
Alyssa Riglos,Teresa M Gunn,Jennifer H Kong
Alyssa Riglos
Mahogunin Ring Finger 1 (MGRN1) is a multifunctional E3 ubiquitin ligase with broad biological significance and belongs to a small group of membrane-tethered E3s capable of regulating signaling receptors at the plasma membrane. Studies in m...
Unraveling new functions of the Ca2+ sensor STIM1 in cell signaling [0.03%]
钙传感器STIM1在细胞信号转导中的新功能机制研究
Irene Sanchez-Lopez,Yolanda Orantos-Aguilera,Aida M Lopez-Guerrero et al.
Irene Sanchez-Lopez et al.
Calcium (Ca2+) signaling is a fundamental regulator of virtually all aspects of eukaryotic cell physiology, including gene expression, secretion, metabolism, motility, and cell fate decisions. The spatial and temporal control of cytosolic C...
Mimetics of in-cell and subcellular crowding and solvation for protein folding [0.03%]
用于蛋白质折叠的细胞内外和亚细胞拥挤及溶剂化的模拟能力
Edward Knab,Ume Tahir,Caitlin M Davis
Edward Knab
Historically, fundamental principles of protein folding were extracted from dilute in vitro experiments that disregarded the complexity of the cell interior. It is now well-established that the cellular environment modulates protein behavio...
How intrinsically disordered regions shape the function of CREB-binding protein [0.03%]
内在无序区域如何塑造CREB结合蛋白的功能
Grace Gilbert,Daniel A Bose
Grace Gilbert
CREB-binding protein (CBP) is a histone acetyltransferase and transcriptional co-activator that operates across the genome at cis-regulatory elements (CREs) to regulate gene expression. Comprising the majority of the protein, CBP has intrin...
Alexander K Buell
Alexander K Buell
Amyloid fibrils formed by α-synuclein are a hallmark of a range of neurodegenerative diseases, notably Parkinson's disease, multiple system atrophy (MSA), and dementia with Lewy bodies, collectively known as synucleinopathies. Recent years...