Mechanisms of transcriptional regulation of CCR5, which is the co-receptor for R5-tropic HIV and is also involved in other disease processes [0.03%]
CCR5转录调控机制的研究——一种辅助HIV-R5病毒入侵及参与其他疾病进程的共受体
Lingyun Wang,Sharon Veron Akisa,Richard Sutton
Lingyun Wang
C-C chemokine receptor type 5 (CCR5) is the R5-tropic human immunodeficiency virus type 1 or HIV co-receptor. Lower CCR5 levels can reduce T cell and macrophage susceptibility and suppress HIV infection. Moreover, CCR5Δ32 homozygous stem c...
A phase separation hypothesis for the biological function of PrP: the role of multivalent interactions at the plasma membrane [0.03%]
PrP 生物功能的相分离假说：关于血浆膜上多价相互作用的作用
Maria Heloisa Freire,Rafael Linden,Yraima Cordeiro
Maria Heloisa Freire
Although the prion protein (PrP) is well established as the etiological agent of transmissible spongiform encephalopathies, its biological function remains under debate. Native, cellular PrP (PrPC) is a glycosylphosphatidylinositol-anchored...
Lipids regulate epidermal growth factor receptor activation by its ligands [0.03%]
脂质通过其配体调节表皮生长因子受体的活化
James M Hutchison,Mark A Lemmon
James M Hutchison
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that has garnered extensive interest since its discovery as an oncogene product in the 1980s. We now understand that the binding of soluble growth factors to EGFR act...
Loop dynamics, allostery, and function in protein tyrosine phosphatases: insights from molecular simulations [0.03%]
蛋白质酪氨酸磷酸酶中的环状动力学、别构效应与功能：从分子模拟中获得的启示
Colin L Welsh,Shina Caroline Lynn Kamerlin
Colin L Welsh
Enzymes are dynamic entities, and their conformational dynamics are intimately linked to their function and evolvability. In this context, protein tyrosine phosphatases (PTPs) are an excellent model system to probe the role of conformationa...
Targeting opportunities presented by the pyrimidine biosynthesis pathway in Mycobacterium tuberculosis: a brief review [0.03%]
针对分枝杆菌嘧啶生物合成途径的机遇：综述
Marta Alberti,Riccardo Miggiano
Marta Alberti
Mycobacterium tuberculosis (MTB) is the etiologic agent of tuberculosis (TB) in humans, an infectious disease that continues to be a significant global health concern. The long-term use of multiple anti-tubercular agents may result in patie...
Regulation of renal aquaporins: implications in tubular epithelial integrity [0.03%]
肾部水孔蛋白的调节：上皮细胞完整性的意义
Vishalini Venkatesan,Charlotte M Sørensen,Emma Tina B Olesen
Vishalini Venkatesan
Aquaporins (AQPs) are crucial membrane proteins that primarily facilitate water transport across cell membranes. In the kidneys, AQP1, AQP7, AQP8, and AQP11 are expressed in the proximal tubules. AQP1 is also localized to the thin descendin...
Regulation and activity of the phosphatase SHP2: SH2 domains, dephosphorylation activity, and beyond [0.03%]
SHP2磷酸酶的调控和功能：SH2结构域、去磷酸化活性及其更多作用
Catia L Pierotti,Maja Köhn
Catia L Pierotti
Src homology 2 (SH2) domain-containing phosphatase-2 (SHP2, PTPN11) is implicated in diseases such as cancer and RASopathies, where it is often mutated. It has gained strong attention due to promising new drug development strategies, with d...
Adriana Simizo,Mauro de Morais,Matheus Vesco et al.
Adriana Simizo et al.
Artificial intelligence (AI) has become a transformative tool in cell biology, driving discoveries through the analysis of complex biological data. This review explores the diverse applications of AI, including its impact on microscopy, ima...
eIF3: a critical player in mRNA recruitment to the ribosome with emerging roles across translation [0.03%]
吴若愚，王晨歌，舒明春｜eIF3：参与招募mRNA到核糖体的重要因子及其在翻译过程中的新角色
Nicholas A Ide,Sufana Noorwez,Christine Xu et al.
Nicholas A Ide et al.
Eukaryotic translation initiation factor (eIF) 3 is a multi-subunit protein complex that plays critical roles throughout translation initiation and has been implicated in a variety of human diseases. More recently, eIF3 has been tied to tra...
Heparan sulphate and neural development: dissecting the roles of astrocyte-expressed heparan sulphate [0.03%]
肝硫酸盐与神经发育：分离星形胶质细胞表达的肝硫酸盐的作用
Martina Gyimesi,Rachel K Okolicsanyi,Larissa M Haupt
Martina Gyimesi
Astrocytes are key regulators of neurogenesis, synaptogenesis, synaptic transmission and the clearance of pathological factors within the brain, while maintaining homeostasis throughout life. They also aid in the establishment and maintenan...