Communication is key: combinatorial phosphorylation and functional cross-talk in the RNA polymerase II CTD code [0.03%]
交流是关键：RNA聚合酶II CTD密码的组合型磷酸化及功能交叉通讯
Y Jessie Zhang,Erin Ramsey
Y Jessie Zhang
The C-terminal domain (CTD) of the largest subunit of RNA polymerase II serves as a dynamic platform coordinating transcription and RNA processing. Recent advances in mass spectrometry, structural biology, and sequencing approaches have rev...
The tumor microenvironment in pancreatic cancer: from composition to therapeutic targeting [0.03%]
胰腺癌的肿瘤微环境：从组成到靶向治疗
Beatriz Magalhães Gomes,Pedro Luiz Porfirio Xavier
Beatriz Magalhães Gomes
Pancreatic cancer, predominantly represented by Pancreatic Ductal Adenocarcinoma (PDAC), is one of the most frequent and deadly types of cancer. In contrast with other types of cancer, for which advances in prevention, early detection, and ...
Deciphering influenza B virus-derived peptides and their presentation by HLA class I molecules [0.03%]
流感B病毒衍生肽的解读及其由HLA-I分子提呈的研究
Janesha C Maddumage,Georgia R Dow,Lawton D Murdolo et al.
Janesha C Maddumage et al.
Despite influenza vaccines being widely available, influenza still causes significant morbidity and mortality annually. Vaccines typically induce humoral-mediated protection against rapidly mutating surface glycoproteins, necessitating that...
Vasundara Sundaravadivelu,Ritesh Kumar Raipuria,Aashish Ranjan
Vasundara Sundaravadivelu
The plant cell cycle is a highly coordinated and regulated process that integrates endogenous and environmental signals to control cell division, meristem maintenance, and cell fate specification for growth and development. Temperature is a...
Kristine Oleinika,Michael C Carroll
Kristine Oleinika
Systemic lupus erythematosus develops when autoreactive B cells escape tolerance and enter differentiation pathways that sustain pathogenic autoantibody responses. A defining feature of lupus is the evolving autoantibody repertoire, in whic...
Role of post-translational modifications in modulating histone reactivity in the extracellular environment [0.03%]
表观遗传修饰在体外环境中调节组蛋白活性的作用机制研究
Helen Hemmling,Clare L Hawkins
Helen Hemmling
Histones are critical for the packaging of nuclear DNA and chromatin assembly, which is facilitated by the high abundance of lysine and arginine residues within these proteins. These residues are the site of post-translational modifications...
Myoferlin at the crossroad of vesicle trafficking and mitochondrial function: implications for pancreatic cancer progression and stromal reprogramming [0.03%]
肌细胞生成蛋白介导囊泡运输和线粒体功能：胰腺癌进展和肿瘤相关成纤维细胞重塑的潜在机制研究
Raphaël Peiffer,Emilie Laverdeur,Aline Genbauffe et al.
Raphaël Peiffer et al.
Myoferlin, a type 2 transmembrane protein in the ferlin family, is traditionally known for its role in membrane fusion during muscle development and repair. Recent research identifies myoferlin as a potential biomarker and a critical driver...
Understanding adipocyte heterogeneity across species, depot, and disease [0.03%]
跨物种、脂肪库和疾病的脂肪细胞异质性解读
Elizabeth S Kitto,Shiri Kult Perry,Margo P Emont
Elizabeth S Kitto
Adipose tissue is a key regulator of metabolic homeostasis; however, its dysfunction can lead to complications, including the development of metabolic disease. While mature adipocytes play an important role in this relationship, their size ...
Austin H Ablicki,Katharine L Diehl
Austin H Ablicki
Biosensors enable the in situ measurement of metabolites in living systems over time and space. Fully genetically encoded metabolite biosensors (fGEMBs) use fluorescent proteins (FPs) linked to ligand binding domains (LBDs) to transduce the...
Hemraj Meena,Katon Wibowo,Nicola De Franceschi
Hemraj Meena
Bottom-up membrane reconstitution has become a powerful framework to investigate the physical principles governing membrane organization and function in highly controlled environments. Among the broad range of available model systems, suppo...